The protective effects of vitamin A in experimental myoglobinuric renal failure

Effect of Ficus carica (fig) seed oil administration on GSH levels, necrosis and cast formation in myoglobinuric acute kidney injury

“…As a matter of fact, in the study of Nara et al in MAKI, it was reported that the early period findings of renal tubular injuries observed with myoglobin accumulations and larger stained areas were observed to increase at the 1 st and 3 rd hours 39 . The histopathological findings that we detected at 72 hours in our study are consistent with the study of Tajik et al in which tissue section samples taken at 96 th hour showed necrosis between 50-100% in the glycerol group 40 . In the study of Moggio et al kidney tissue damage begins to deteriorate at the 12 th hour after the functional parameters begin to deteriorate, necrotic areas appear after 12 hours, cast formations and necrotic areas with casts to the tubule lumen reach their peak at the 72 nd hour, at the 240 th hour.…”

“…In the study conducted by Fernandez et al it was shown that the increase in serum urea and cratinine levels in the acute renal failure model created with 10 ml/kg 50% glycerol was more than the 24 th hour in the 72 nd hour 8 . In another study, in a rhabdomyolysis model created with 50% glycerol at doses of 7 ml/kg, higher urea and creatinine values were reported 96 hours after glycerol injection, similar to our increase rates at 72 nd hour, compared to the control group 40 . Al Laham reported high urea and creatinine levels up to the 6 th day in (acute renal failure) ARF induced by 50% glycerol 33 .…”