The Protective Effects of α-Lipoic Acid on Kidneys in Type 2 Diabetic Goto-Kakisaki Rats via Reducing Oxidative Stress

Feng, Bo; Yan, Xiaoxiao; Xue, Junli; Xu, Lei; Wang, Hua

doi:10.3390/ijms14046746

Cited by 49 publications

(37 citation statements)

References 22 publications

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“…In patients with diabetes, there is increased production of AGEs [28] and due to overgeneration of reactive oxygen species (ROS), causing an imbalance and produces OS [44]. GSH is a tripeptide present in all cells in micromolar concentrations has great antioxidative property [45,46]. Low levels of GSH in T2DM patients in our study are in accordance withfindings of other studies [47][48][49][50][51].…”

Section: Discussionsupporting

confidence: 92%

Effect of Alpha Lipoic Acid in Treatment of Type 2 Diabetes

Panda

Mishra

2017

Asian J Pharm Clin Res

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Section: Discussionsupporting

confidence: 92%

Effect of Alpha Lipoic Acid in Treatment of Type 2 Diabetes

Panda

Mishra

2017

Asian J Pharm Clin Res

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“…According to Feng et al [14] α-lipoic acid has effects on the kidneys of diabetic rats, increasing the levels of GSH, SOD, vitamins E, and C in ALA-treated group, compared to the diabetic group. Further evidence for in vivo efficiency of ALA in inflammatory diseases is given by the fact that ALA inhibits airway inflammation in a mouse model of asthma.…”

Section: Discussionmentioning

confidence: 99%

Antioxidative effects of α-lipoic acid in the brain, liver and kidneys in selected mouse organs exposed to zymosan

Goc¹,

Greń²,

Kapusta³

et al. 2015

Acta Biologica Hungarica

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This study investigated the role of exogenous α-lipoic acid (ALA) in the inflammation caused by zymosan application. Seventy-two adult male white mice were divided into twelve groups: three control groups, three Zymosan groups, three ALA groups and three groups being the combination of Zymosan and ALA. In the experimental groups, the animals were decapitated after 3, 6 and 24 hours after the injection. The activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) were determined in the brain, liver and kidneys of the mice. After the injection of Zymosan, it was found that the activity of SOD, CAT and GSH-Px in the brain, liver and kidneys of mice was significantly lower in all time periods. The administration of ALA resulted in an opposite effect, namely, it increased the activity of the enzymes studied in the selected organs of mice. The Zymosan and ALA combination significantly inhibited the decrease in the activity of the enzymes compared with the values obtained in the groups of animals which received Zymosan only. The results of our study, using the Zymosan-induced inflammation, clearly indicate that ALA is an anti-inflammatory agent.

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“…78 Several studies have reported that GK rats exhibit the common histological changes in the kidneys that are observed in other animal models of diabetes, including thickening of glomerular basement membranes, mild to moderate mesangial matrix expansion, glomerular hypertrophy, oxidative stress, and inflammation. [79][80][81] However, even older GK rats do not exhibit progressive renal damage, which is characterized by the development of global glomerulosclerosis, marked mesangial matrix expansion, nodular formation, progressive proteinuria, tubulointerstitial fibrosis, and renal dysfunction.…”

Section: Wf Ratsmentioning

confidence: 99%

Rodent models of diabetic nephropathy: their utility and limitations

Kitada¹,

Ogura²,

Koya³

2016

IJNRD

200

151

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Diabetic nephropathy is the most common cause of end-stage renal disease. Therefore, novel therapies for the suppression of diabetic nephropathy must be developed. Rodent models are useful for elucidating the pathogenesis of diseases and testing novel therapies, and many type 1 and type 2 diabetic rodent models have been established for the study of diabetes and diabetic complications. Streptozotocin (STZ)-induced diabetic animals are widely used as a model of type 1 diabetes. Akita diabetic mice that have an Ins2+/C96Y mutation and OVE26 mice that overexpress calmodulin in pancreatic β-cells serve as a genetic model of type 1 diabetes. In addition, db/db mice, KK-Ay mice, Zucker diabetic fatty rats, Wistar fatty rats, Otsuka Long-Evans Tokushima Fatty rats and Goto-Kakizaki rats serve as rodent models of type 2 diabetes. An animal model of diabetic nephropathy should exhibit progressive albuminuria and a decrease in renal function, as well as the characteristic histological changes in the glomeruli and the tubulointerstitial lesions that are observed in cases of human diabetic nephropathy. A rodent model that strongly exhibits all these features of human diabetic nephropathy has not yet been developed. However, the currently available rodent models of diabetes can be useful in the study of diabetic nephropathy by increasing our understanding of the features of each diabetic rodent model. Furthermore, the genetic background and strain of each mouse model result in differences in susceptibility to diabetic nephropathy with albuminuria and the development of glomerular and tubulointerstitial lesions. Therefore, the validation of an animal model reproducing human diabetic nephropathy will significantly facilitate our understanding of the underlying genetic mechanisms that contribute to the development of diabetic nephropathy. In this review, we focus on rodent models of diabetes and discuss the utility and limitations of these models for the study of diabetic nephropathy.

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The Protective Effects of α-Lipoic Acid on Kidneys in Type 2 Diabetic Goto-Kakisaki Rats via Reducing Oxidative Stress

Cited by 49 publications

References 22 publications

Effect of Alpha Lipoic Acid in Treatment of Type 2 Diabetes

Effect of Alpha Lipoic Acid in Treatment of Type 2 Diabetes

Antioxidative effects of α-lipoic acid in the brain, liver and kidneys in selected mouse organs exposed to zymosan

Rodent models of diabetic nephropathy: their utility and limitations

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