The Protective of Baicalin on Myocardial Ischemia-Reperfusion Injury

Liu, Xiaoli; Zhang, Shanshan; Xu, Chaoyue; Sun, Yongchao; Sui, Shujian; Zhang, Zhaohua; Luan, Yun

doi:10.2174/1389201021666200605104540

Cited by 15 publications

(4 citation statements)

References 31 publications

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“…Baicalin is a flavonoid derivative isolated from the traditional Chinese medicine Scutellaria baicalensis Georgi, with significant pharmacological activities, including anti-inflammatory, immunomodulatory, and antioxidant effects [ 173 , 174 ]. Baicalin improves cardiac function and myocardial fibrosis in rats with myocardial infarction, possibly through the p38 phosphorylation and TGFβ1/Smad2 pathway, exhibiting a protective effect against MI/R injury [ 175 ].…”

Section: Molecular Mechanism Of Natural Products Regulating Ferroptos...mentioning

confidence: 99%

Research advances on molecular mechanism and natural product therapy of iron metabolism in heart failure

Zhang,

Luo,

et al. 2024

Eur J Med Res

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The progression of heart failure (HF) is complex and involves multiple regulatory pathways. Iron ions play a crucial supportive role as a cofactor for important proteins such as hemoglobin, myoglobin, oxidative respiratory chain, and DNA synthetase, in the myocardial energy metabolism process. In recent years, numerous studies have shown that HF is associated with iron dysmetabolism, and deficiencies in iron and overload of iron can both lead to the development of various myocarditis diseases, which ultimately progress to HF. Iron toxicity and iron metabolism may be key targets for the diagnosis, treatment, and prevention of HF. Some iron chelators (such as desferrioxamine), antioxidants (such as ascorbate), Fer-1, and molecules that regulate iron levels (such as lactoferrin) have been shown to be effective in treating HF and protecting the myocardium in multiple studies. Additionally, certain natural compounds can play a significant role by mediating the imbalance of iron-related signaling pathways and expression levels. Therefore, this review not only summarizes the basic processes of iron metabolism in the body and the mechanisms by which they play a role in HF, with the aim of providing new clues and considerations for the treatment of HF, but also summarizes recent studies on natural chemical components that involve ferroptosis and its role in HF pathology, as well as the mechanisms by which naturally occurring products regulate ferroptosis in HF, with the aim of providing reference information for the development of new ferroptosis inhibitors and lead compounds for the treatment of HF in the future.

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Section: Molecular Mechanism Of Natural Products Regulating Ferroptos...mentioning

confidence: 99%

Research advances on molecular mechanism and natural product therapy of iron metabolism in heart failure

Zhang,

Luo,

et al. 2024

Eur J Med Res

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“…Luan et al demonstrated that by regulating the Akt/NF-κB signaling pathway, baicalin downregulated myocardial apoptosis and inflammation ( 62 ). Liu et al reported that LV functions were improved and myocardial apoptosis was suppressed by baicalin via suppressing the CaSR/ERK1/2 signaling pathway in myocardial I/R injury rats ( 63 ). Xu et al reported the protective effect of baicalin, via the JAK/STAT pathway, on myocardial I/R injury.…”

Section: Cardioprotective Phytochemicals Attenuating Myocardial I/r I...mentioning

confidence: 99%

Promising Therapeutic Candidate for Myocardial Ischemia/Reperfusion Injury: What Are the Possible Mechanisms and Roles of Phytochemicals?

Chen

Cheng

et al. 2022

Front. Cardiovasc. Med.

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Percutaneous coronary intervention (PCI) is one of the most effective reperfusion strategies for acute myocardial infarction (AMI) despite myocardial ischemia/reperfusion (I/R) injury, causing one of the causes of most cardiomyocyte injuries and deaths. The pathological processes of myocardial I/R injury include apoptosis, autophagy, and irreversible cell death caused by calcium overload, oxidative stress, and inflammation. Eventually, myocardial I/R injury causes a spike of further cardiomyocyte injury that contributes to final infarct size (IS) and bound with hospitalization of heart failure as well as all-cause mortality within the following 12 months. Therefore, the addition of adjuvant intervention to improve myocardial salvage and cardiac function calls for further investigation. Phytochemicals are non-nutritive bioactive secondary compounds abundantly found in Chinese herbal medicine. Great effort has been put into phytochemicals because they are often in line with the expectations to improve myocardial I/R injury without compromising the clinical efficacy or to even produce synergy. We summarized the previous efforts, briefly outlined the mechanism of myocardial I/R injury, and focused on exploring the cardioprotective effects and potential mechanisms of all phytochemical types that have been investigated under myocardial I/R injury. Phytochemicals deserve to be utilized as promising therapeutic candidates for further development and research on combating myocardial I/R injury. Nevertheless, more studies are needed to provide a better understanding of the mechanism of myocardial I/R injury treatment using phytochemicals and possible side effects associated with this approach.

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“…Baicalin, a monomeric flavonoid compound, is the main medicinal component of Scutellaria baicalensis Georgi, which has highlighted extensive pharmacological properties such as cardiovascular diseases, cancer, hypertension, ischemic heart disease, and atherosclerosis in numerous studies ( Li Y. et al, 2020 ; Liu X. et al, 2020 ; Xin et al, 2020 ; Singh et al, 2021 ). In addition, a large body of publications have reported that baicalin possessed a protective effect on hypoxia-induced PAH, which was mediated by increasing the expression of ADAMTS-1 ( Liu et al, 2015 ), targeting the Akt/HIF1α/p27-associated pathway ( Zhang L. et al, 2014 ), enhancing A 2A R activity, downregulating SDF-1/CXCR4-induced PI3K/Akt signaling ( Huang et al, 2017 ), and suppressing the HIF1α and AhR pathways ( Huang et al, 2014 ).…”

Section: Preclinical Studies Of Traditional Herbal Medicine For Pulmonary Arterial Hypertension Treatmentmentioning

confidence: 99%

Traditional Herbal Medicine Discovery for the Treatment and Prevention of Pulmonary Arterial Hypertension

Xue

Zhou

et al. 2021

Front. Pharmacol.

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Pulmonary arterial hypertension (PAH) is characterized by pulmonary artery remodeling that may subsequently culminate in right heart failure and premature death. Although there are currently both non-pharmacological (lung transplantation, etc.) and pharmacological (Sildenafil, Bosentan, and new oral drugs on trial) therapies available, PAH remains a serious and fatal pulmonary disease. As a unique medical treatment, traditional herbal medicine (THM) treatment has gradually exerted its advantages in treating PAH worldwide through a multi-level and multi-target approach. Additionally, the potential mechanisms of THM were deciphered, including suppression of proliferation and apoptosis of pulmonary artery smooth muscle cells, controlling the processes of inflammation and oxidative stress, and regulating vasoconstriction and ion channels. In this review, the effects and mechanisms of the frequently studied compound THM, single herbal preparations, and multiple active components from THM are comprehensively summarized, as well as their related mechanisms on several classical preclinical PAH models. It is worth mentioning that sodium tanshinone IIA sulfonate sodium and tetramethylpyrazine are under clinical trials and are considered the most promoting medicines for PAH treatment. Last, reverse pharmacology, a strategy to discover THM or THM-derived components, has also been proposed here for PAH. This review discusses the current state of THM, their working mechanisms against PAH, and prospects of reverse pharmacology, which are expected to facilitate the natural anti-PAH medicine discovery and development and its bench-to-bedside transformation.

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The Protective of Baicalin on Myocardial Ischemia-Reperfusion Injury

Cited by 15 publications

References 31 publications

Research advances on molecular mechanism and natural product therapy of iron metabolism in heart failure

Research advances on molecular mechanism and natural product therapy of iron metabolism in heart failure

Promising Therapeutic Candidate for Myocardial Ischemia/Reperfusion Injury: What Are the Possible Mechanisms and Roles of Phytochemicals?

Traditional Herbal Medicine Discovery for the Treatment and Prevention of Pulmonary Arterial Hypertension

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