2020
DOI: 10.1111/jth.14942
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The protective rather than prothrombotic fibrinogen in COVID‐19 and other inflammatory states

Abstract: COVID-19 continues to cause significant mortality around the world.One of the key pathogenic features observed in COVID-19 is the intense inflammation induced by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) with the development of a cytokine storm in the most severe cases. From the coagulation perspective, colleagues from different parts of the world have noted several-fold increase in fibrinogen levels in many patients who require critical care support. [1][2][3] Why might the fibrinogen l… Show more

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Cited by 27 publications
(31 citation statements)
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“…The results show, the D-dimer, troponin, and brinogen were increase from admission and their levels remained high until the fatal outcome. The brinogen and troponin increase can be due to the double protective function it plays, regulating the antiviral function of the immune cells, and assisting the host protective formation of brin matrices or clots that serve as a protective barrier that limits the spread of the virus (Thachil et al, 2020). However, this condition results in coagulation abnormalities that are associated with a substantial COVID-19 mortality rate (Levi et al, 2020).…”
Section: Discussionmentioning
confidence: 99%
“…The results show, the D-dimer, troponin, and brinogen were increase from admission and their levels remained high until the fatal outcome. The brinogen and troponin increase can be due to the double protective function it plays, regulating the antiviral function of the immune cells, and assisting the host protective formation of brin matrices or clots that serve as a protective barrier that limits the spread of the virus (Thachil et al, 2020). However, this condition results in coagulation abnormalities that are associated with a substantial COVID-19 mortality rate (Levi et al, 2020).…”
Section: Discussionmentioning
confidence: 99%
“…The reason for the changes observed in the measurement of these parameters was described by Thachil [ 19 ]. Patients with COVID-19 initially have elevated levels of fibrinogen as a result of the body’s developing inflammatory response and immune defense.…”
Section: Levels Of D-dimer and Fibrinogen In Covid-19mentioning
confidence: 99%
“…Ranucci et al described a significant association of interleukin-6 with fibrinogen levels [ 23 ]. At the beginning of an acute phase reaction fibrinogen’s function seems to be predominant to its role in clot formation [ 24 ]. The in the course induced hyperfibrinogenemia has a protective role as part of the host defense against pathogens [ 24 ].…”
Section: Discussionmentioning
confidence: 99%
“…At the beginning of an acute phase reaction fibrinogen’s function seems to be predominant to its role in clot formation [ 24 ]. The in the course induced hyperfibrinogenemia has a protective role as part of the host defense against pathogens [ 24 ]. However, a prothrombotic risk factor of a high fibrinogen level is still discussed [ 19 , 25 , 26 ].…”
Section: Discussionmentioning
confidence: 99%