The protective role of Gallic acid in Cisplatin nephrotoxicity

Kotb, Ebtesam Samir; Serag, Waleed M.; Elshaarawy, Reda F.M.; Hafez, Hani S.; El-Khayat, Zakaria

doi:10.21608/fsrt.2021.77860.1040

Cited by 6 publications

(6 citation statements)

References 33 publications

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“…KIM-1 has been proposed as a non-invasive biomarker for proximal tubular injury in humans 58 . Our previous study showed that the kidney functions increased significantly in the CDDP group compared to the control group and GA group, as well as, the kidney functions were decreased in the (CDDP + GA) group compared to the CDDP group alone 59 . In the current study, GA@CMCS, which combines the benefits of GA and CMCS, showed a higher ability than GA and CMCS, respectively for minimizing CDDP-induced nephrotoxicity.…”

Section: Discussionmentioning

confidence: 91%

The diminution and modulation role of water-soluble gallic acid-carboxymethyl chitosan conjugates against the induced nephrotoxicity with cisplatin

Hafez

Kotb

El-Khayat

et al. 2022

Sci Rep

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The toxicity of cisplatin (CDDP) toward the renal tubules and its severe effects on the proximal tubules limits its further use in cancer therapy. The current study was undertaken to evaluate the protective effects of gallic acid-grafted O-carboxymethyl chitosan (GA@CMCS) against nephrotoxicity induced by CDDP in rats. Renal injury was assessed in the GA@CMCS/CDDP-treated rats using kidney injury molecule-1 (KIM-1). Moreover, the levels of reduced glutathione (GSH), malondialdehyde (MDA), and nitric oxide (NO) were measured. The comet assay was performed to measure the DNA damage. The renoprotective activity of GA@CMCS was supported by histo- and immuno-pathological studies of the kidney. GA@CMCS significantly normalized the increases in kidney homogenate of KIM-1, MDA, and NO-induced by CDDP and significantly increased GSH as compared with the CDDP group. GA@CMCS also significantly protects rat kidneys from CDDP-induced histo- and immuno-pathological changes. Both biochemical findings and histo- and immuno-pathological evidence showed the renoprotective potential of GA@CMCS against CDDP-induced oxidative stress, inflammation, and renal dysfunction in rats. In conclusion, GA@CMCS has been shown to mitigate the nephrotoxicity impact of CDDP in cancer therapy.

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Section: Discussionmentioning

confidence: 91%

The diminution and modulation role of water-soluble gallic acid-carboxymethyl chitosan conjugates against the induced nephrotoxicity with cisplatin

Hafez

Kotb

El-Khayat

et al. 2022

Sci Rep

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“…In the same manner, Said et al (2015) stated that administration of CP significantly impaired oxidant/antioxidant balance and increased TNF-α level, with a significant impairment of kidney architecture and functions. TNF-α plays a key role in activating a large network of chemokines and cytokines, which mediates renal injury by inducing apoptosis (Yao et al, 2007;Sanz et al, 2008&Kotb et al, 2021.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Gallic Acid on Cyclophosphamide-Induced Nephrotoxicity, Oxidative Stress, Genotoxicity, and Histopathological Alterations in Male Albino Rats

Elwakeel

Rahman

2021

Egyptian Academic Journal of Biological Sciences, B. Zoology

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Cyclophosphamide (CP) is a chemotherapeutic agent used to treat various types of cancer. Despite its nervous, hepatic, renal, and cytotoxic side effects, it is a highly effective agent whether used alone or in combination with other chemotherapeutics. This study was designed to examine the prophylactic effects of Gallic acid (GA) on CP-induced acute renal toxicity. Male Wistar albino rats were divided into six groups, 6 animals each: G1 was given normal saline and served as -ve control, while G2 and G3 were given i.p injections of 100 and 200 mg/kg GA, respectively, for 15 days. G4 was used as a +ve control and received a single i.p. injection of CP (150 mg/kg). G5 and G6 were treated with the two different doses of GA for 15 days before receiving a single i.p. injection of CP. Animals were euthanized 24 hrs after the last treatment, and their kidneys were carefully dissected out for histological, immunohistochemical investigation of Zona occluden-1(ZO-1), and biochemical examination, as well as the evaluation of P53, apoptotic markers and tumor necrosis factor-alpha (TNF-α) gene expressions. Blood samples were also taken to determine serum creatinine and urea levels. The intake of GA improved kidney function, as evidenced by lower levels of kidney toxicity markers (urea and creatinine). GA significantly reduced the percent of DNA fragmentation in renal tissue via modulating the levels of glutathione (GSH) and catalase (CAT) enzymes as well as malondialdehyde (MDA). Furthermore, GA reduced renal TNF-α and P53 gene expressions and improved the kidney's histological architecture as well as increasing of ZO-1 immunoexpression. In conclusion, the findings of this study indicate that GA protects against CP-induced renal toxicity via an anti-inflammatory and antioxidant mechanism. We believe that GA may have prophylactic effects against CP-induced nephrotoxicity.The Protective Effect of Gallic Acid on Cyclophosphamide-Induced Nephrotoxicity, Oxidative Stress, Genotoxicity, and Histopathological Alterations in Male Albino Rats.designated to help in finding a protective therapeutic approach to prevent the destructive effect of oxidative stress induced by CP and it may be beneficial for patients who have been using CP for a long time. MATERIALS AND METHODS Drugs and Chemicals:Cyclophosphamide (Endoxan -Sigma-Aldrich Chemical Co. St. Louis, Missouri, USA) was dissolved in sterile water and freshly prepared immediately before each intraperitoneal injection.Gallic acid (purity: 99.5%) extra pure was obtained from Sigma Aldrich Company (USA). All chemicals and reagents used during the experiment met the highest purity grade value according to international standards. Animals:Thirty-six adult male Wister albino rats, weighing (170-200 g), aged 7-9 weeks old were used in this study. Animals were obtained from the Animal House Colony, National Research Centre, and Cairo, Egypt. The males were chosen according to an earlier study which found that the clastogenic effects of CP were more prominent in males than females (Krishna et ...

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“…KIM-1 has been proposed as a non-invasive biomarker for proximal tubular injury in humans 56 . Our previous study showed that the kidney functions increased significantly (p < 0.001) in the CDDP group compared to the control group and GA group, as well as, the kidney functions were decreased (p < 0.001) in the (CDDP + GA) group compared to the CDDP group alone 57 . Additionally, in the current study, KIM-1 levels were considerably higher in the CDDP group and the (CDDP + GA) group in comparison to the control group.…”

Section: Nitric Oxide (No)mentioning

confidence: 91%

The reversible and modulation role of water-soluble gallic acid-carboxymethyl chitosan conjugates against the induced nephrotoxicity with cisplatin

Hafez

El-Khayat²,

Kotb

et al. 2022

Preprint

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The toxicity of cisplatin (CDDP) toward the renal tubules and its severe effects on the proximal tubules limits its futher use for cancer therapy. The current study was undertaken to evaluate the protective effects of gallic acid-grafted O-carboxymethyl chitosan (GA@CMLMWC) against nephrotoxicity induced by CDDP in rats. Renal injury was assessed in the GA@CMLMWC/CDDP-treated rats using kidney injury molecule-1 (KIM-1). Moreover, the levels of reduced glutathione (GSH), malondialdehyde (MDA), and nitric oxide (NO) were measured. The comet assay was performed to measure the DNA damage. The renoprotective activity of GA@CMLMWC was supported by histo- and immuno-pathological studies of the kidney. GA@CMLMWC significantly normalized the increases in kidney homogenate of KIM-1, MDA, and NO-induced by CDDP and significantly increased GSH as compared with the CDDP group. GA@CMLMWC also significantly protects rat kidneys from CDDP-induced histo- and immuno-pathological changes. Both biochemical findings and histo- and immuno-pathological evidence showed the renoprotective potential of GA@CMLMWC against CDDP-induced oxidative stress, inflammation, and renal dysfunction in rats. In conclusion, GA@CMLMWC has been shown to mitigate the nephrotoxicity impact of CDDP in cancer therapy.

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The protective role of Gallic acid in Cisplatin nephrotoxicity

Cited by 6 publications

References 33 publications

The diminution and modulation role of water-soluble gallic acid-carboxymethyl chitosan conjugates against the induced nephrotoxicity with cisplatin

The diminution and modulation role of water-soluble gallic acid-carboxymethyl chitosan conjugates against the induced nephrotoxicity with cisplatin

Protective Effect of Gallic Acid on Cyclophosphamide-Induced Nephrotoxicity, Oxidative Stress, Genotoxicity, and Histopathological Alterations in Male Albino Rats

The reversible and modulation role of water-soluble gallic acid-carboxymethyl chitosan conjugates against the induced nephrotoxicity with cisplatin

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