The protective role of interaction between vitamin D, sex hormones and calcium in multiple sclerosis

Haghmorad, Dariush; Soltanmohammadi, Azita; Tavaf, Maryam Jadid; Zargarani, Simin; Yazdanpanah, Esmaeil; Shadab, Alireza; Yousefi, Bahman

doi:10.1080/00207454.2022.2147431

Cited by 4 publications

(2 citation statements)

References 232 publications

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“…Previous studies have found that external calcium ion can activate calcium ion channels of macrophages and regulate immune response. [19,20] In addition, calcium ion can promote the migration and differentiation of MSCs, thereby accelerating the formation of blood vessels and new bones at the defect site. [21] Chen et al reported that the Mg-doped β-TCP ceramics could increase the secretion of BMP-2 and IL1RA by macrophages, thereby accelerating bone healing and osseointegration of implant with host bone.…”

Section: Coupling Bcp Ceramics With Micro-vibration Stimulation Field...mentioning

confidence: 99%

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Coupling BCP Ceramics with Micro‐Vibration Stimulation Field for Cascade Amplification from Immune Activation to Bone Regeneration

Wang

et al. 2023

Adv Funct Materials

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The osteoimmunology has revealed that immune system plays an important role in maintaining bone metabolism and remodeling. As long‐term physiological factor in bone, mechanical stimulation such as micro‐vibration stimulation (MVS) exerts effects on regulating osteogenesis and immune response. In this study, the osteo‐immunodulatory effects of bicalcium phosphate (BCP) ceramics coupled with MVS are investigated. This results find that the combination of BCP ceramics and MVS may exert synergistic effects on the polarization and functional status of macrophages through activating plasma membrance Ca2+ ATPase (PMCA) channel, reducing the intracellular calcium ion concentration, and inhibiting downstream extracellular signal‐regulated kinase (ERK)1/2 signaling pathway. BCP ceramics coupled MVS could drive the macrophage polarization to wound‐healing M2 phenotype to decrease the production of pro‐inflammatory factors, enhance the secretion of anti‐inflammatory cytokines and growth factors such as transforming growth factor (TGF)‐β1 and bone morphogenetic protein (BMP)‐2. Moreover, BCP and MVS‐modulated macrophage secretion pattern can trigger the BMP/TGF‐Smad signaling pathways to induce osteoblastic differentiation of bone marrow mesenchymal stromal cells (BM‐MSCs) in vitro, and maintain cellular viability and promote the formation of collagen‐rich osteoid like tissues and mature blood vessels in vivo. This study demonstrates that the introduction of mechanical stimuli like non‐invasive MVS is an effective strategy to improve bone repair effects of biomaterials through endowing them with superior osteo‐immunodulatory capacity.

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Section: Coupling Bcp Ceramics With Micro-vibration Stimulation Field...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Coupling BCP Ceramics with Micro‐Vibration Stimulation Field for Cascade Amplification from Immune Activation to Bone Regeneration

Wang

et al. 2023

Adv Funct Materials

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The Brain–Gut–Bone Axis in Neurodegenerative Diseases: Insights, Challenges, and Future Prospects

Li,

Miao,

Liu

et al. 2024

Advanced Science

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Neurodegenerative diseases are global health challenges characterized by the progressive degeneration of nerve cells, leading to cognitive and motor impairments. The brain–gut–bone axis, a complex network that modulates multiple physiological systems, has gained increasing attention owing to its profound effects on the occurrence and development of neurodegenerative diseases. No comprehensive review has been conducted to clarify the triangular relationship involving the brain–gut–bone axis and its potential for innovative therapies for neurodegenerative disorders. In light of this, a new perspective is aimed to propose on the interplay between the brain, gut, and bone systems, highlighting the potential of their dynamic communication in neurodegenerative diseases, as they modulate multiple physiological systems, including the nervous, immune, endocrine, and metabolic systems. Therapeutic strategies for maintaining the balance of the axis, including brain health regulation, intestinal microbiota regulation, and improving skeletal health, are also explored. The intricate physiological interactions within the brain–gut–bone axis pose a challenge in the development of effective treatments that can comprehensively target this system. Furthermore, the safety of these treatments requires further evaluation. This review offers a novel insights and strategies for the prevention and treatment of neurodegenerative diseases, which have important implications for clinical practice and patient well‐being.

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Curcumin’s spice-infused therapeutic promise: disease severity alleviation in a mouse model of multiple sclerosis via modulation of immune responses

Amiri,

Jalili,

Tarahomi

et al. 2023

Mol Biol Rep

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The protective role of interaction between vitamin D, sex hormones and calcium in multiple sclerosis

Cited by 4 publications

References 232 publications

Coupling BCP Ceramics with Micro‐Vibration Stimulation Field for Cascade Amplification from Immune Activation to Bone Regeneration

Coupling BCP Ceramics with Micro‐Vibration Stimulation Field for Cascade Amplification from Immune Activation to Bone Regeneration

The Brain–Gut–Bone Axis in Neurodegenerative Diseases: Insights, Challenges, and Future Prospects

Curcumin’s spice-infused therapeutic promise: disease severity alleviation in a mouse model of multiple sclerosis via modulation of immune responses

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