The protective role of propolis against multi heavy metals-induced oxidative stress-hepato-renal damage in the male of albino rats

Abstract

The study was designed to clarify the hepato-renal protective effects of propolis extract against heavy metals-induced toxicity via oral administration to the males of albino rats. Lead (Pb), Nickel (Ni), Cadmium (Cd), and Antimony (Sb) are toxic heavy metals have the ability to produce reactive radicals in the biological systems causing public and animals health hazards through disrupting balances between pro-oxidant and antioxidant defense system, resulting in excessive reactive oxygen species (ROS) production. The most commonly affected organs are liver and kidney. Propolis is a natural product with different shapes and resinous substance collected by honey bees, it attenuates many diseases damage due to its anti-oxidative action and its potentiality to minimize the deleterious effects of free radicals on tissues. The concentrations of Pb, Cd, Ni and Sb as well as the activities of antioxidants endogenous enzymes including; glutathione peroxidase (Gpx), glutathione reductase (GR), catalase (CAT), and superoxide dismutase (SOD) were all determined in the tissues of liver and kidney; while aspartate transaminase (ASAT), alanine transaminase (ALAT), total protein (TP), urea and createnine, were measured in the serum of experimental rats beside histopathologicl examination in the tissues of liver and kidney. The oral administration of propolis provided a significantly therapeutic role against multi-metals-induced hepato-renal toxicity with relative improving to histopathological changes because of its scavenging and chelating properties as concluded from the present investigation.

An Innovative Use of Propolis in the Production of Dipping Sauce Powder as a Functional Food to Mitigate Testicular Toxicity Induced by Cadmium Chloride: Technological and Biological Evidence

“…According to Abu-Almaaty et al [ 40 ] and El-Amawy et al [ 41 ], propolis has a protective effect on different organs of albino rats due to its antioxidant function against oxidative stress caused by heavy metals; moreover, propolis improved the histopathology and the morphometry of the testicular tissues in groups treated with propolis-containing diets. Hashem [ 42 ] studied the preventive properties of propolis against testicular damage caused by carbon tetrachloride (CCl 4 ) and found that propolis increased testosterone levels while decreasing oxidant levels.…”

Protective Effects of Nigella Sativa and Propolis against Cadmium or Lead Induced Nephrotoxicity: An Experimental Histological and Biochemical Study

“…In addition, propolis is a natural material that contains phenolic and flavonoid chemicals, which have been found to be able to be a scavenger for free radicals, keeping lipids and other molecules away from oxidative damage and inhibiting lipid peroxidation [10] . Propolis action was thought to be by different mechanisms including chelation or antagonism of heavy metals in order to decrease their production of free radicals, counteracting their oxidative effect and interfering with the reaction of auto-oxidative chain [11] .…”