The protective role of regular aerobic exercise on vascular function with aging

Craighead, Daniel H.; Freeberg, Kaitlin A.; Seals, Douglas R.

doi:10.1016/j.cophys.2019.04.005

Cited by 13 publications

(6 citation statements)

References 110 publications

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Section: Effects Of Dietary Nitrite and Nitrate On Vascular Healthmentioning

confidence: 99%

“…Comprehensive reviews on possible strategies for improving vascular dysfunction with aging can be found elsewhere (71,72,73). Briefly, lifestyle practices, including regular aerobic exercise and consuming a healthy diet (i.e., healthy energy intake and nutrient composition), are the most evidence-based strategies for preserving vascular function with aging (71,72,73). However, numerous barriers exist for consistent practice of healthy lifestyle strategies and, as a result, adherence to physical activity and dietary guidelines is poor at the population level.…”

Section: Effects Of Dietary Nitrite and Nitrate On Vascular Healthmentioning

confidence: 99%

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Dietary Nitrate and Nitric Oxide Metabolism: Mouth, Circulation, Skeletal Muscle, and Exercise Performance

Jones

Vanhatalo

Seals

et al. 2020

Medicine &Amp; Science in Sports &Amp; Exercise

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Nitric oxide (NO) is a gaseous signaling molecule that plays an important role in myriad physiological processes including the regulation of vascular tone, neurotransmission, mitochondrial respiration and skeletal muscle contractile function.NO may be produced via the canonical NOS-catalyzed oxidation of l-arginine and also by the sequential reduction of nitrate to nitrite and then NO. The body's nitrate stores can be augmented by the ingestion of nitrate-rich foods (primarily green leafy vegetables). NO bioavailability is greatly enhanced by the activity of bacteria residing in the mouth which reduce nitrate to nitrite, thereby increasing the concentration of circulating nitrite which can be reduced further to NO in regions of low oxygen availability. Recent investigations have focused on promoting this nitrate-nitrite-NO pathway to positively impact indices of cardiovascular health and exercise tolerance.It has been reported that dietary nitrate supplementation with beetroot juice lowers blood pressure in hypertensive patients whereas sodium nitrite supplementation improves vascular endothelial function and reduces stiffening of large elastic arteries in older humans. Nitrate supplementation has also been shown to enhance skeletal muscle function and to improve exercise performance in some circumstances.Recently, it has been established that nitrate concentration in skeletal muscle is much higher than that in blood and that muscle nitrate stores are exquisitely sensitive to dietary nitrate supplementation and deprivation. In this review, we consider the possibility that nitrate represents an essential storage form of NO and discuss the integrated function of the oral microbiome, the circulation and skeletal muscle in nitrate-nitrite-NO metabolism as well as the practical relevance for health and performance.

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Section: Effects Of Dietary Nitrite and Nitrate On Vascular Healthmentioning

confidence: 99%

Section: Effects Of Dietary Nitrite and Nitrate On Vascular Healthmentioning

confidence: 99%

Dietary Nitrate and Nitric Oxide Metabolism: Mouth, Circulation, Skeletal Muscle, and Exercise Performance

Jones

Vanhatalo

Seals

et al. 2020

Medicine &Amp; Science in Sports &Amp; Exercise

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“…78 Indeed, flow-mediated dilation declines across the menopausal transition, 79 and AT does not consistently improve endothelial function in postmenopausal women as it does in men. 80 The significant impact of estradiol is further demonstrated in an RCT assessing the effect of 12 weeks of moderate-intensity AT in women treated with either placebo, oral, or transdermal estradiol—Moreau et al 81 reported increased flow-mediated dilation in women who had undergone estradiol therapy compared with placebo-treated women. This finding suggests that estradiol is necessary to induce the beneficial effects of AT on endothelial function in postmenopausal women.…”

Section: Pathways By Which Exercise Can Modify Csvdmentioning

confidence: 98%

Prevention of Vascular Contributions to Cognitive Impairment and Dementia: The Role of Physical Activity and Exercise

Dao,

Barha,

Zou

et al. 2024

Stroke

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Vascular contributions to cognitive impairment and dementia, specifically cerebral small vessel disease (CSVD), are the second most common cause of dementia. Currently, there are no specific pharmacological treatments for CSVD, and the use of conventional antidementia drugs is not recommended. Exercise has the potential to prevent and mitigate CSVD-related brain damage and improve cognitive function. Mechanistic pathways underlying the neurocognitive benefits of exercise include the control of vascular risk factors, improving endothelial function, and upregulating exerkines. Notably, the therapeutic efficacy of exercise may vary by exercise type (ie, aerobic versus resistance training) and biological sex; thus, studies designed specifically to examine these moderating factors within a CSVD context are needed. Furthermore, future research should prioritize resistance training interventions, given their tremendous therapeutic potential. Addressing these knowledge gaps will help us refine exercise recommendations to maximize their therapeutic impact in the prevention and mitigation of CSVD.

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“…El entrenamiento concurrente a través de la capacidad aeróbica produce alteraciones benéficas a nivel fisiológico en la disminución del tejido adiposo, mejora en el consumo de oxígeno (VO2), el sistema cardiorrespiratorio, la función arterial y en el cumplimiento con vigorosidad de las actividades de la vida cotidiana (Anderson & Durstine, 2019;Craighead et al, 2019;Murlasits et al, 2018).…”

Section: Palabras Clavesunclassified

Efectos del entrenamiento concurrente sobre de la condición física en aprendices SENA

Cabrera

2021

REDIIS

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El sedentarismo es un factor crítico para el aumento de enfermedades no transmisibles (ENT), sin embargo, la implementación de programas de entrenamiento genera un valor positivo en la promoción de hábitos saludables en la población adulta, la atribución del entrenamiento concurrente conlleva a optimizar y fortalecer la salud del ser humano a nivel cardiorrespiratorio y locomotor. Objetivo: Conocer en qué proporción mejora la fuerza y la resistencia aeróbica con dos días seguidos a la semana de entrenamiento físico, durante el período trimestral de formación de 11 semanas y con un tiempo 60 a 70 minutos por sesión de entrenamiento, para determinar si el entrenamiento concurrente tiene influencia sobre el mejoramiento de la condición física en una población de estudiantes del Centro de Gestión Administrativa SENA con 46 estudiantes. Método: El tipo de estudio es cuantitativo, descriptivo y correlacional, para lo cual se tendrán en cuenta las variables de IMC (índice de masa corporal), edad, condición física y método de entrenamiento aplicado durante la intervención. Conclusión: La incidencia del entrenamiento concurrente es positiva en la condición física de la población a evaluar.

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The protective role of regular aerobic exercise on vascular function with aging

Cited by 13 publications

References 110 publications

Dietary Nitrate and Nitric Oxide Metabolism: Mouth, Circulation, Skeletal Muscle, and Exercise Performance

Dietary Nitrate and Nitric Oxide Metabolism: Mouth, Circulation, Skeletal Muscle, and Exercise Performance

Prevention of Vascular Contributions to Cognitive Impairment and Dementia: The Role of Physical Activity and Exercise

Efectos del entrenamiento concurrente sobre de la condición física en aprendices SENA

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