The protective role of resveratrol in diabetic wound healing

Abstract

Diabetic wounds are severe complications of diabetes mellitus (DM), which have difficulty in healing. Although diverse treatments have been used, the prognosis of diabetic wounds is not satisfactory; therefore, an effective therapy to accelerate diabetic wound healing is urgently needed. In our review, we summarized that resveratrol can promote diabetic wound healing by protecting against hyperglycemia, inflammation, oxidative stress, vascular pathology, infection, and peripheral neuropathy. To clarify it clearly, we highlighted its underlying mechanisms of protective effects of resveratrol against diabetic wounds, and high‐quality studies are needed to firmly establish its clinical efficacy. Otherwise, with the development of material sciences, resveratrol can exert its therapeutic effectiveness efficiently; however, more high‐quality studies are needed to confirm the clinical efficacy of resveratrol on diabetic wounds.

Quercetin inhibits calcium oxalate crystallization and growth but promotes crystal aggregation and invasion

“…Natural food compounds and related products have been continuously investigated for their potential to be used as the novel therapeutic strategies in several diseases, especially those induced by oxidative stress and inflammation ( Luo et al, 2023 ; Mirmohammadali and Rosenkranz, 2023 ; Nisar et al, 2023 ). Plant-based anti-oxidants, such as vitamin E ( Nisar et al, 2023 ), catechin ( Baranwal et al, 2022 ; Talebi et al, 2021 ), caffeic acid ( Ganguly et al, 2023 ; Pandey et al, 2023 ), gallic acid ( Bhuia et al, 2023 ; Keyvani-Ghamsari et al, 2023 ), resveratrol ( Bi et al, 2023 ; Ramli et al, 2023 ), diosmin ( Gerges et al, 2022 ; Mustafa et al, 2022 ) and quercetin ( Shabir et al, 2022 ; Zhou et al, 2023 ), have been shown to rescue the oxidative stress conditions by scavenging ROS and their intermediates, reducing localized oxygen levels, chelating metal ion, and inhibiting lipid peroxidation. They have been applied for prevention of several diseases, e.g., neurodegenerative disorders, cardiovascular diseases, atherosclerosis, diabetes, and cancers ( Baranwal et al, 2022 ; Bhuia et al, 2023 ; Bi et al, 2023 ; Ganguly et al, 2023 ; Gerges et al, 2022 ; Keyvani-Ghamsari et al, 2023 ; Luo et al, 2023 ; Mirmohammadali and Rosenkranz, 2023 ; Mustafa et al, 2022 ; Nisar et al, 2023 ; Pandey et al, 2023 ; Ramli et al, 2023 ; Shabir et al, 2022 ; Talebi et al, 2021 ; Zhou et al, 2023 ).…”