The protective role of resveratrol against zinc oxide induced nanotoxicity

Abstract

Zinc oxide (ZnO) is a compound that has harmful effects as well as being used in many different areas. Numerous studies have been carried out to minimize the toxic effects of ZnO nanoparticles (NPs). In the present study, the protective role of resveratrol (RSV), a potent antioxidant polyphenol substance, was examined against ZnO-induced nanotoxicity on human pulmonary alveolar epithelial cells (HPAEpiC). In this context, the cytotoxic and genotoxic effects of different concentrations of RSV (5, 10, 20 mg/L) and ZnO NPs on the cells were measured alone and in combination. At the same time, the effects of aforementioned applications on the total antioxidant capacity (TAC) level in HPAEpiC were assessed. The results obtained showed that ZnO NPs alone significantly increased cytotoxicity and genotoxicity on cells compared to negative control (control (-)). In the experiments performed with RSV + ZnO NP combination, cytotoxic and genotoxic activity decreased at the level of p < 0.05 especially at 20 mg/L application of RSV. When the level of TAC in cells was examined, a concentration-dependent increase was detected between TAC and RSV. It was determined that ZnO NPs reduced the TAC level statistically (p < 0.05) in comparison with control (-). In conclusion, the present study revealed that RSV, a natural antioxidant, showed protective property against genotoxic and cytotoxic damage induced by ZnO NPs on HPAEpiC.

Modulating the Photostability of (E)-Resveratrol in Grape Cane Extract Formulations

“…In addition, stilbenoids from grape cane extracts might lower the potential nanotoxicity of zinc oxide, as recently proposed by Emsen and Turkez. 32 Further studies might focus on the interactions regarding the stability and fungicidal efficacy of such promising combinations.…”

Resveratrol ve 1,3-bis(2-kloroetil)-1-nitrozüre kombinasyonunun YKG1 glioblastoma hücreleri üzerine etkileri

“…It acts through signaling pathways related to growth factors and receptor tyrosine kinases and interferes with signal transduction by the growth factor β. Experimental studies have demonstrated that resveratrol might impact apoptosis by regulating molecules that comprise caspase-3, p53, peroxisome proliferatoractivated receptor, NfκB, Bax, Bcl-2, and apoptotic protease activating factor-1 (Emsen and Turkez, 2017;Rauf et al, 2018).…”

Resveratrol Inhibits Oxidative Stress and Prevents Mitochondrial Damage Induced by Zinc Oxide Nanoparticles in Zebrafish (Danio rerio)

“…Within phytochemicals, resveratrol, a compound occurring in many fruits like grapes, mulberries, peanuts, and cocoa, has been widely reported to exhibit antioxidant and scavenging activities [23]. In addition, emerging studies have reported a protective role of resveratrol against toxicity induced by nanomaterials [24] and ZnO NPs in epithelial cells, Nile tilapia, and Caenorhabditis elegans [25,26]. While there is a copious number of in vitro studies on the protective effects of antioxidants against NP-induced damage, there are few works carried out in vivo, and none in zebrafish embryos despite the advantages related to their utilization.…”