ObjectiveThis study explored perfectionism, self‐compassion and personal growth initiative in clinical dental hygienists.MethodsCross‐sectional survey research was conducted with a non‐probability sample of clinical dental hygienists (n = 877). The survey had 55 items and consisted of three validated instruments: Frost's Multidimensional Perfectionism Scale—Brief (including evaluative concerns and perfectionistic striving subscales), Neff's Self‐Compassion Scale and Robitschek's Personal Growth Initiative Scale. Descriptive, correlation, t‐test, ANOVA and logistic regression analyses were used to evaluate the relationships among variables. Mediation analysis was conducted to determine the presence of a mediated moderation effect of self‐compassion on perfectionism and personal growth initiative.ResultsThe completion rate for the survey was 89% (n = 788). Evaluative concerns (M = 11.83) and perfectionistic strivings (M = 15.44) among dental hygienists were high, levels of self‐compassion (SC) were moderate (M = 2.87) and levels of personal growth initiative (PGI) were low (M = 38.07) compared to others not in the dental field. The mediation analysis found that SC mediates the relationship between perfectionistic evaluative concerns and PGI. It was also determined that SC mediates the relationship between perfectionistic strivings and PGI.ConclusionDental hygienists have high levels of perfectionism and may lack necessary levels of self‐compassion to counteract those perfectionistic tendencies resulting in a decrease in taking the initiative to engage in opportunities for growth. This suggests the importance of dental hygienists developing a more adaptive perfectionism to balance self‐criticism along with not having unrealistic expectations for perfection while engaging in self‐compassion that includes self‐kindness and mindfulness to support their continued growth.