The protective role of squalene in alcohol damage in the chick embryo retina

Aguilera, Yolanda; Dorado, Manuel E.; Prada, Francisco A.; Martínez, Juan J.; Quesada, A.; Ruı́z-Gutı́errez, Valentina

doi:10.1016/j.exer.2004.11.003

Cited by 57 publications

(35 citation statements)

References 29 publications

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“…Several studies have indicated that squalene is an important dietary cancer chemopreventive agent [5]. More recently, squalene has been shown to act as an antidote to reduce accidental drug-induced toxicities [6,7]. The protective effect of squalene may be attributed to its ability to serve as an antioxidant.…”

Section: Introductionmentioning

confidence: 99%

Phytosterol, Squalene, Tocopherol Content and Fatty Acid Profile of Selected Seeds, Grains, and Legumes

Ryan

Galvin

O’Connor

et al. 2007

Plant Foods Hum Nutr

485

285

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The unsaponifiable lipid fraction of plant-based foods is a potential source of bioactive components such as phytosterols, squalene, and tocopherols. The objective of the present study was to determine the levels of phytosterols, and squalene, as well as tocopherols (alpha and beta + gamma) in selected grains, seeds, and legumes. The method comprised acid hydrolysis and lipid extraction followed by alkaline saponification, prior to analysis by HPLC. In addition, the fatty acid profile of the foods was determined via total lipid extraction, fatty acid derivitisation and GC analysis. In general, beta-sitosterol was the most prevalent phytosterol, ranging in concentration from 24.9 mg/100 g in pumpkin seed to 191.4 mg/100 g in peas. Squalene identified in all foods examined in this study, was particularly abundant in pumpkin seed (89.0 mg/100 g). The sum of alpha- and beta+ gamma-tocopherols ranged from 0.1 mg/100 g in rye to 15.9 mg/100 g in pumpkin seeds. Total oil content ranged from 0.9% (w/w) in butter beans to 42.3% (w/w) in pumpkin seed and the type of fat, in all foods examined, was predominantly unsaturated. In conclusion, seeds, grains, and legumes are a rich natural source of phytosterols. Additionally, they contain noticeable amounts of squalene and tocopherols, and in general, their fatty acid profile is favorable.

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Section: Introductionmentioning

confidence: 99%

Phytosterol, Squalene, Tocopherol Content and Fatty Acid Profile of Selected Seeds, Grains, and Legumes

Ryan

Galvin

O’Connor

et al. 2007

Plant Foods Hum Nutr

485

285

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“…Several research works have reported its biochemical importance as antioxidant [8][9][10] and chemopreventive agent [11]. During the last century, shark liver oil was the largest source of squalene extraction [12]; however, nowadays vegetable sources are mostly exploited such as olive oil [13,14] and oily seeds [12,15].…”

Section: Introductionmentioning

confidence: 99%

Squalene Extraction by Supercritical Fluids from Traditionally Puffed Amaranthus hypochondriacus Seeds

Rosales-García

Jiménez‐Martínez

Cardador‐Martínez

et al. 2017

Journal of Food Quality

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Extraction of squalene, a potent natural antioxidant, from puffed A. hypochondriacus seeds was performed by supercritical fluid extraction (SCFE); besides, to have a blank for comparison, extraction was performed also by Soxhlet method using organic solvents (hexane). Chemical proximal composition and seed morphology were determined in raw, puffed, and SCFE-extracted seeds. Extracts were obtained with a 500 mL capacity commercial supercritical extractor and performed between 10 and 30 MPa at 313, 323, and 333 K under constant CO 2 flow of 0.18 kg CO 2 /h during 8 h. The squalene content was determined and the fatty acids present in the extracts were identified by GC-MS. The extract obtained by SCFE from puffed amaranth seeds reached 460 ± 28.1 g/kg squalene in oily extract at 313 K/20 MPa.

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“…The biological importance of squalene is varied, and it can act enhancing effects of the immune system [38], blocking singlet oxygen in biological systems, and presents chimoprotective effects against cancer [39,40]. Considering these active properties and the scarcity of the shark species in which squalene is common, other sources have been studied, such as amaranth [34] and olive oil [41].…”

Section: Cobia Liver Oilmentioning

confidence: 99%

Supercritical Extraction of Cobia (Rachycentron canadum) Liver Oil as a New Source of Squalene

Santos¹,

Takahashi²,

Verde³

et al. 2016

fph

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Cobia is a fish cultivated worldwide and there are few studies on the potential of their waste, such as the liver, it's rich in oil and active compounds. The objective of this study was to extract cobia liver oil (CLO) using supercritical CO 2 under moderate temperature conditions (50, 60 and 70 °C, 250 bar) and characterize the oil (physico-chemical analysis, fatty acids profile and squalene content). The results showed that CLO is rich in MUFA and presented squalene, suggesting that this matrix can be applied in the production of high nutritional value oil.

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The protective role of squalene in alcohol damage in the chick embryo retina

Cited by 57 publications

References 29 publications

Phytosterol, Squalene, Tocopherol Content and Fatty Acid Profile of Selected Seeds, Grains, and Legumes

Phytosterol, Squalene, Tocopherol Content and Fatty Acid Profile of Selected Seeds, Grains, and Legumes

Squalene Extraction by Supercritical Fluids from Traditionally Puffed Amaranthus hypochondriacus Seeds

Supercritical Extraction of Cobia (Rachycentron canadum) Liver Oil as a New Source of Squalene

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