The protective role of virgin coconut oil on the alloxan-induced oxidative stress in the liver, kidneys and heart of diabetic rats

Đurašević, Siniša; Jasnić, Nebojša; Prokić, Marko D.; Grigorov, Ilijana; Martinović, Vesna; Đorđević, Jelena; Pavlović, Slađan

doi:10.1039/c9fo00107g

Cited by 23 publications

(14 citation statements)

References 55 publications

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“…This result might be attributed to the addition of coconut oil as an inducer of obesity to the high saturated fat diet in our experiment. This prediction is supported by multiple studies that highlight the antioxidant effects of virgin coconut oil [39,40].…”

Section: Discussionmentioning

confidence: 60%

High-fat diet-induced obesity and impairment of brain neurotransmitter pool

Labban

Alfawaz

Almnaizel

et al. 2020

Translational Neuroscience

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AbstractObesity and the brain are linked since the brain can control the weight of the body through its neurotransmitters. The aim of the present study was to investigate the effect of high-fat diet (HFD)-induced obesity on brain functioning through the measurement of brain glutamate, dopamine, and serotonin metabolic pools. In the present study, two groups of rats served as subjects. Group 1 was fed a normal diet and named as the lean group. Group 2 was fed an HFD for 4 weeks and named as the obese group. Markers of oxidative stress (malondialdehyde, glutathione, glutathione-s-transferase, and vitamin C), inflammatory cytokines (interleukin [IL]-6 and IL-12), and leptin along with a lipid profile (cholesterol, triglycerides, high-density lipoprotein, and low-density lipoprotein levels) were measured in the serum. Neurotransmitters dopamine, serotonin, and glutamate were measured in brain tissue. Fecal samples were collected for observing changes in gut flora. In brain tissue, significantly high levels of dopamine and glutamate as well as significantly low levels of serotonin were found in the obese group compared to those in the lean group (P > 0.001) and were discussed in relation to the biochemical profile in the serum. It was also noted that the HFD affected bacterial gut composition in comparison to the control group with gram-positive cocci dominance in the control group compared to obese. The results of the present study confirm that obesity is linked to inflammation, oxidative stress, dyslipidemic processes, and altered brain neurotransmitter levels that can cause obesity-related neuropsychiatric complications.

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Section: Discussionmentioning

confidence: 60%

High-fat diet-induced obesity and impairment of brain neurotransmitter pool

Labban

Alfawaz

Almnaizel

et al. 2020

Translational Neuroscience

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“…While LDL-C is responsible for the delivery of cholesterol to peripheral tissues, HDL-C mediates the inverse process of cholesterol transport from peripheral tissues [35]. The non-signi cant decrease of HDL-C in obese rats reported in the present study may be related to the anti-oxidative effect of coconut oil, a component of the HFD used here [33,34].…”

Section: Discussionmentioning

confidence: 50%

“…The unexpected non-signi cant increase of MDA and decrease in GSH levels, GST activity, and vitamin C levels in HFD-induced obese rats might be attributed to the addition of coconut oil to the high saturated fat diet given in our paradigm as an inducer of obesity. Multiple studies demonstrate the anti-oxidative effects of virgin coconut oil, supporting this hypothesis [33,34]. Table 2 also shows the independent and synergistic effects of mangosteen pericarp extract and curcumin on oxidative stressrelated variables.…”

Section: Discussionmentioning

confidence: 56%

Garcinia Mangostana Extract and Curcumin Ameliorate Oxidative Stress, Dyslipidemia, and Hyperglycemia in High Fat Diet-induced Obese Wistar Albino Rats

Labban

fawaz

Almnaizel

et al. 2021

Preprint

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Background:Obesity is a risk factor for several diseases related to oxidative stress, hyperlipidemia, and hyperglycemia. Several pharmacological agents have been used to treat obesity, but these commonly exhibit undesirable side effects. The aim of this study was to explore the effects of Garcinia mangostana (mangosteen) and Curcuma longa independently and synergistically in modulating selected biochemical markers of oxidative stress, dyslipidemia, and hyperglycemia commonly observed in high-fat diet-induced obesity in rodent models. Methods:Male albino Wistar rats were divided into eight experimental groups, fed on a normal diet or high-fat diet (HFD), then given mangosteen extract (400 mg /kg body weight/day) and/or curcumin (80 mg/kg body weight/day) for 6 weeks. Oxidative stress markers, glucose, and lipid fractions were measured in the sera. Results:Curcumin was found to be more effective in reducing BMI, while mangosteen extract was found to induce a significant increase in anti-atherogenic marker HDL-C, but was ineffective in reducing dyslipidemia. Mangosteen extract and curcumin effectively reduced blood glucose. Mangosteen did not exhibit any anti-oxidative effects in normal weight rats; however, it induced a significant increase in glutathione in obese rats. Conclusion:The present study demonstrated that mangosteen pericarp extract and curcumin were independently and synergistically effective in treating obesity-induced atherogenesis.

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“…In kidneys, changes in the activity of the antioxidant enzymes suggest increased antioxidant protection, and thus reduced oxidative stress. As previously reported, the increase in MnSOD activity can be perceived as a more effective way in the removal of the respiratory chain-derived superoxide anion radicals, hence reducing the propagation of oxidative stress from mitochondria to the cytoplasm, and reducing CuZnSOD activity [52]. Since superoxide anion dismutation results in the production of hydrogen peroxide, a reduction in CuZnSOD activity would lower H 2 O 2 production, therefore decreasing the activity of both CAT and GSH-Px as well.…”

Section: Assessment Of the Oxidative Statusmentioning

confidence: 71%

The Effects of a Meldonium Pre-Treatment on the Course of the Faecal-Induced Sepsis in Rats

Đurašević

Ružičić

Lakić

et al. 2021

IJMS

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Sepsis is a life-threatening condition caused by the dysregulated and overwhelming response to infection, accompanied by an exaggerated pro-inflammatory state and lipid metabolism disturbance leading to sequential organ failure. Meldonium is an anti-ischemic and anti-inflammatory agent which negatively interferes with lipid metabolism by shifting energy production from fatty acid oxidation to glycolysis, as a less oxygen-demanding pathway. Thus, we investigated the effects of a four-week meldonium pre-treatment on faecal-induced sepsis in Sprague-Dawley male rats. Surprisingly, under septic conditions, meldonium increased animal mortality rate compared with the meldonium non-treated group. However, analysis of the tissue oxidative status did not provide support for the detrimental effects of meldonium, nor did the analysis of the tissue inflammatory status showing anti-inflammatory, anti-apoptotic, and anti-necrotic effects of meldonium. After performing tissue lipidomic analysis, we concluded that the potential cause of the meldonium harmful effect is to be found in the overall decreased lipid metabolism. The present study underlines the importance of uninterrupted energy production in sepsis, closely drawing attention to the possible harmful effects of lipid-mobilization impairment caused by certain therapeutics. This could lead to the much-needed revision of the existing guidelines in the clinical treatment of sepsis while paving the way for discovering new therapeutic approaches.

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The protective role of virgin coconut oil on the alloxan-induced oxidative stress in the liver, kidneys and heart of diabetic rats

Abstract: Our results show that VCO supplementation ameliorates some toxic effects of alloxan induced diabetes, and that the changes are tissue specific.

Cited by 23 publications

References 55 publications

High-fat diet-induced obesity and impairment of brain neurotransmitter pool

High-fat diet-induced obesity and impairment of brain neurotransmitter pool

Garcinia Mangostana Extract and Curcumin Ameliorate Oxidative Stress, Dyslipidemia, and Hyperglycemia in High Fat Diet-induced Obese Wistar Albino Rats

The Effects of a Meldonium Pre-Treatment on the Course of the Faecal-Induced Sepsis in Rats

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