The protective role of water intake in age-related eye diseases: insights from a Mendelian randomization study

Mi, Yuze; Zhu, Qinnan; Zheng, Xinni; Wan, Minghui

doi:10.1039/d4fo01559b

Cited by 4 publications

(1 citation statement)

References 54 publications

(69 reference statements)

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“…Cataract, a prevalent eye disorder, is identified by clouding of the ocular lens, which impairs visual acuity ( 234 ). This ailment can impact either a single eye or both simultaneously.…”

Section: Ferroptosis and Ophthalmic Disordersmentioning

confidence: 99%

Ferroptosis: a novel mechanism of cell death in ophthalmic conditions

Yang,

Lin,

Han

et al. 2024

Front. Immunol.

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Ferroptosis, a new type of programmed cell death proposed in recent years, is characterized mainly by reactive oxygen species and iron-mediated lipid peroxidation and differs from programmed cell death, such as apoptosis, necrosis, and autophagy. Ferroptosis is associated with a variety of physiological and pathophysiological processes. Recent studies have shown that ferroptosis can aggravate or reduce the occurrence and development of diseases by targeting metabolic pathways and signaling pathways in tumors, ischemic organ damage, and other degenerative diseases related to lipid peroxidation. Increasing evidence suggests that ferroptosis is closely linked to the onset and progression of various ophthalmic conditions, including corneal injury, glaucoma, age-related macular degeneration, diabetic retinopathy, retinal detachment, and retinoblastoma. Our review of the current research on ferroptosis in ophthalmic diseases reveals significant advancements in our understanding of the pathogenesis, aetiology, and treatment of these conditions.

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“…Cataract, a prevalent eye disorder, is identified by clouding of the ocular lens, which impairs visual acuity ( 234 ). This ailment can impact either a single eye or both simultaneously.…”

Section: Ferroptosis and Ophthalmic Disordersmentioning

confidence: 99%

Ferroptosis: a novel mechanism of cell death in ophthalmic conditions

Yang,

Lin,

Han

et al. 2024

Front. Immunol.

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The causal association between plasma caffeine and frailty: A two-sample mendelian randomization study

Mi,

Lin,

Chen

et al. 2025

Archives of Gerontology and Geriatrics

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Impact of Physical Activity Frequency, Duration, and Intensity on Senile Cataract Risk: A Mendelian Randomization Study

Mi,

Zhu,

Chen

et al. 2024

Trans. Vis. Sci. Tech.

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Purpose We aimed to determine the causal effects of physical activities with different frequencies, durations, and intensities on the risk of senile cataracts using Mendelian randomization (MR). Methods A bidirectional two-sample MR approach was used to determine the association between physical activity and senile cataract risk. Our primary analysis used the inverse variance weighted method, and secondary analyses included MR-Egger regression, MR-PRESSO, and Cochran's Q statistic to evaluate heterogeneity and pleiotropy. Causal estimates were presented as odds ratios (ORs) with 95% confidence intervals (95% CIs). Results Genetically predicted moderate physical activity ≥ 10 min/wk (OR = 0.765, 95% CI = 0.627–0.936, P = 8.73E-03), vigorous physical activity ≥ 10 min/wk (OR = 0.691, 95% CI = 0.521–0.917, P = 1.04E-02), moderate-to-vigorous physical activity levels (OR = 0.552, 95% CI = 0.369–0.823, P = 3.75E-03), and overall acceleration average (OR = 0.952, 95% CI = 0.926–0.978, P = 3.80E-04) were associated with a decreased risk of senile cataract while walking ≥ 10 min/wk (OR = 0.972, 95% CI = 0.741–1.275, P = 8.36E-01) had no significant correlation. The reverse MR analysis showed no reversal causality from senile cataract to physical activity except for walking ≥ 10 min/wk (OR = 0.951, 95% CI = 0.923–0.979, P = 7.30E-04). Conclusions Our findings suggest that moderate to vigorous physical activity with higher frequency and longer duration will causally reduce the risk of senile cataracts, and there is no reverse causal relationship. Translational Relevance These findings underscore the potential of incorporating physical activity into preventive health strategies for senile cataracts.

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The protective role of water intake in age-related eye diseases: insights from a Mendelian randomization study

Abstract: Age-related eye diseases (AREDs), including age-related cataracts (ARCs), age-related macular degeneration (AMD), diabetic retinopathy (DR), and glaucoma, are a leading cause of visual loss globally. This study aimed to explore...

Cited by 4 publications

References 54 publications

Ferroptosis: a novel mechanism of cell death in ophthalmic conditions

Ferroptosis: a novel mechanism of cell death in ophthalmic conditions

The causal association between plasma caffeine and frailty: A two-sample mendelian randomization study

Impact of Physical Activity Frequency, Duration, and Intensity on Senile Cataract Risk: A Mendelian Randomization Study

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