The Protein-Bound Plasma Iodine in Patients with Thyroid Disease

Lowenstein, Bertrand E.; Bruger, Maurice; Hinton, J. William; Member, Samuel

doi:10.1210/jcem-4-6-268

Cited by 17 publications

(10 citation statements)

References 0 publications

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“…The fall, after iodine medication, of the serum precipitable iodine from a previously elevated level in untreated hyperthyroidism confirms the observations of others (2,3). A greater variability was found in response to iodine, both acutely and chronically, than has sometimes been described.…”

Section: Effects Of Iodine Medication Alonesupporting

confidence: 88%

Serum Iodine in Hyperthyroidism, With Particular Reference to the Effects of Subtotal Thyroidectomy 1

Winkler¹,

Riggs²,

Thompson³

et al. 1946

J. Clin. Invest.

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The concentration of precipitable 2 iodine in serum is a sensitive index of concentration of circulating thyroid hormone (1 to 7). The level of precipitable iodine is characteristically elevated in untreated hyperthyroidism (1 to 3, 6) and tends to fall after iodine medication and after thyroidectomy (3). In the present study the changes following treatment were analyzed with special reference to the development of abnormally low or high levels of precipitable iodine at various intervals after operation. MATERIAL AND METHODSWhenever possible, total or precipitable iodine concentration in serum was measured before any treatment was given. Iodine medication in the form of strong solution of iodine U.S.P., 5 drops 3 times a day, was then given until the day of subtotal thyroidectomy, when it was discontinued. In a few instances the measurement of serum precipitable iodine concentration was repeated just before operation. At various intervals after subtotal thyroidectomy the concentration of iodine in serum was again de-termined. In many instances, including all those in whom the subtotal thyroidectomy was done prior to 1940, postoperative determinations alone were made. Only patients in whom the diagnosis of hyperthyroidism was established by a characteristic clinical picture and by subsequent pathological examination of the gland removed at operation are included. Basal metabolic rate and concentration of cholesterol in serum were also followed postoperatively.In the years during which these observations were made (1940( to Oct., 1944) the technical character of the operation of subtotal thyroidectomy in the New Haven Hospital was planned by one of the authors (K. W. Thompson). The majority of the operations were performed by him, or done under his direction by the resident 1 Aided by grants from the Fluid Research Fund of the Yale University School of Medicine.2The "precipitable" iodine includes all iodine which is precipitated along with the serum proteins. It is the same fraction which is sometimes referred to as "protein bound" or "hormonal" iodine. surgeon. A rather complete standardized thyroidectomy B was carried out in the belief that a radical operation would reduce the incidence of recurrent hyperthyroidism, which is regarded as a highly unfavorable outcome. About 140 operations for subtotal thyroidectomy were performed during this period. An initial determination of the serum total or precipitable iodine was made in 87 instances, and of the whole blood iodine in 26 more. At some time during the first 6 months after operation the serum iodine determination was repeated one or more times in 60 of these cases, which were selected more or less at random. After 6 months serum iodine determinations were made in only 32 of these cases.There were included also 51 additional cases whose operation had been done before 1940; in about half of these cases the subtotal thyroidectomy had been done in the New Haven Hospital before 1940. Unlike the studies during the first 6 postoperative months, many of these later st...

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Section: Effects Of Iodine Medication Alonesupporting

confidence: 88%

Serum Iodine in Hyperthyroidism, With Particular Reference to the Effects of Subtotal Thyroidectomy 1

Winkler¹,

Riggs²,

Thompson³

et al. 1946

J. Clin. Invest.

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“…Usually this error amounts to from 1.0 to 2.0 gamma per cent, but occasionally gross errors occur after excessive intake of inorganic iodine or contamination (2). The normal range of SPI reported by others has been similar to that reported by Winkler, but the maximal variation has not been clearly defined (3)(4)(5)(6)(7). Continued study has also revealed that pituitary or adrenal disease, pregnancy, metabolic disturbances accompanied by disturbed serum proteins, and other conditions to be discussed may, in themselves, be associated with a diminution or increase of the SPI (8)(9)(10)(11).…”

supporting

confidence: 64%

Concentration of Precipitable Iodine in the Serum 1

Kydd¹,

Man²,

Peters³

1950

J. Clin. Invest.

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“…of thyroxin intravenously on 2 successive days. Desiccated thyroid was increased to 3 and then 4 grains daily during the subsequent course of pregnancy; after the effect of intravenous thyroxin had subsided the serum precipitable iodines were 10.0 and 7.8 gamma per cent. She was delivered of a normal baby at term.…”

Section: Resultsmentioning

confidence: 99%