The protein kinase C-η isoform induces proliferation in glioblastoma cell lines through an ERK/Elk-1 pathway

Uht, Rosalie Maire; Amos, Samson; Martin, Patrick; Riggan, Anna E.; Hussaini, Isa M.

doi:10.1038/sj.onc.1210090

Cited by 70 publications

(54 citation statements)

References 38 publications

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“…PKC expression enhances glioma proliferation and cell growth through MEK1/2/ERK1/2/Elk-1 [224] or Akt/mTOR pathways [225]. PKC also plays an important role in rapamycin-insensitive cell proliferation [226].…”

Section: Gastrointestinal Stromal Tumormentioning

confidence: 99%

Protein Kinase C (PKC) Isozymes and Cancer

Kang

2014

New Journal of Science

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Protein kinase C (PKC) is a family of phospholipid-dependent serine/threonine kinases, which can be further classified into three PKC isozymes subfamilies: conventional or classic, novel or nonclassic, and atypical. PKC isozymes are known to be involved in cell proliferation, survival, invasion, migration, apoptosis, angiogenesis, and drug resistance. Because of their key roles in cell signaling, PKC isozymes also have the potential to be promising therapeutic targets for several diseases, such as cardiovascular diseases, immune and inflammatory diseases, neurological diseases, metabolic disorders, and multiple types of cancer. This review primarily focuses on the activation, mechanism, and function of PKC isozymes during cancer development and progression.

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Section: Gastrointestinal Stromal Tumormentioning

confidence: 99%

Protein Kinase C (PKC) Isozymes and Cancer

Kang

2014

New Journal of Science

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“…S6). These genes may coregulate and drive Akt-dependent protection from apoptosis (31,32), together with poly (ADPribose) polymerase family, member 14 (PARP14), B-cell CLL/ lymphoma (BCL) 9, and JUN, which play more general roles in cell proliferation and survival (SI Appendix, Figs. S3C and S6).…”

Section: Biologically Relevant Connections Between In Vivo Duodenalmentioning

confidence: 99%

Human mucosal in vivo transcriptome responses to three lactobacilli indicate how probiotics may modulate human cellular pathways

Baarlen

Troost

Meer

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

299

234

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Probiotic bacteria, specific representatives of bacterial species that are a common part of the human microbiota, are proposed to deliver health benefits to the consumer by modulation of intestinal function through largely unknown molecular mechanisms. To explore in vivo mucosal responses of healthy adults to probiotics, we obtained transcriptomes in an intervention study after a double-blind placebo-controlled cross-over design. In the mucosa of the proximal small intestine of healthy volunteers, probiotic strains from the species Lactobacillus acidophilus, L. casei, and L. rhamnosus each induced differential gene-regulatory networks and pathways in the human mucosa. Comprehensive analyses revealed that these transcriptional networks regulate major basal mucosal processes and uncovered remarkable similarity to response profiles obtained for specific bioactive molecules and drugs. This study elucidates how intestinal mucosa of healthy humans perceives different probiotics and provides avenues for rationally designed tests of clinical applications.gene regulation | host-microbe interactions | lactobacillus | transcriptomics | gut bacteria

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“…The mitogen PMA can be used to activate protein kinase C and consequently, enhances the phosphorylation of ERK1/2 MAP kinase. It has been shown that ERK and ELK-1 are downstream targets of the protein kinase C in glioblastoma multiform cells stimulated with PMA (24). To uncover the biological significance of FBXO25-mediated degradation of ELK-1, we scrutinized whether overexpression of FBXO25 would affect c-fos and egr-1 gene expression in cells stimulated by PMA.…”

Section: Elk-1-flag-6xhis + + + Pcdna3 + --Gst-fbxo25-∆f-box -+ -Gst-mentioning

confidence: 99%

The F-box Protein FBXO25 Promotes the Proteasome-dependent Degradation of ELK-1 Protein

Teixeira¹,

Manfiolli²,

Soares³

et al. 2013

Journal of Biological Chemistry

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The protein kinase C-η isoform induces proliferation in glioblastoma cell lines through an ERK/Elk-1 pathway

Cited by 70 publications

References 38 publications

Protein Kinase C (PKC) Isozymes and Cancer

Protein Kinase C (PKC) Isozymes and Cancer

Human mucosal in vivo transcriptome responses to three lactobacilli indicate how probiotics may modulate human cellular pathways

The F-box Protein FBXO25 Promotes the Proteasome-dependent Degradation of ELK-1 Protein

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