2002
DOI: 10.1038/sj.onc.1205400
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The proto-oncogene c-myc in hematopoietic development and leukemogenesis

Abstract: The proto-oncogene c-myc has been shown to play a pivotal role in cell cycle regulation, metabolism, apoptosis, dierentiation, cell adhesion, and tumorigenesis, and participates in regulating hematopoietic homeostasis. It is a transcription regulator that is part of an extensive network of interacting factors. Most probably, dierent biological responses are elicited by dierent overlapping subsets of c-Myc target genes, both induced and suppressed. Results obtained from studies employing mouse models are consis… Show more

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Cited by 209 publications
(169 citation statements)
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References 87 publications
(74 reference statements)
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“…Lesions in genes that control differentiation may lead to either anemia or leukemia (Hoffman et al, 2002). The autonomously proliferating M1 myeloblastic leukemia cell line is induced by interleukin-6 (IL-6) to undergo terminal macrophage differentiation with concomitant loss of leukemogenicity, providing an attractive model system to analyse the different regulators of terminal differentiation.…”
Section: Introductionmentioning
confidence: 99%
“…Lesions in genes that control differentiation may lead to either anemia or leukemia (Hoffman et al, 2002). The autonomously proliferating M1 myeloblastic leukemia cell line is induced by interleukin-6 (IL-6) to undergo terminal macrophage differentiation with concomitant loss of leukemogenicity, providing an attractive model system to analyse the different regulators of terminal differentiation.…”
Section: Introductionmentioning
confidence: 99%
“…The down-regulated MXI-1 protein is another transcriptional repressor that has been shown to interact with MAX and result in MYC activation. 39 The down-regulated cyclin-dependent kinase (CDK) inhibitor 1B (CDKN1B, p27, Kip1) and cyclin-dependent kinase inhibitor 2D (CDKN2D, p19, inhibits CDK4) are both proteins that bind to CDKs and prevents G1 progression. 40 The ING1 tumor suppressor interacts with p53, thereby promoting cell-cycle arrest and apoptosis, and has been reported to show decreased expression in both lung cancer and acute lymphoblastic leukemia (ALL).…”
Section: Dysregulated Transcription and Cell-cycle Control In The V Hmentioning
confidence: 99%
“…However, the deregulation of c-Myc has been observed in a wide range of human cancers, particularly leukemias and lymphomas, due to gene amplification, translocation, transactivation, or increased protein stability. Deregulated c-Myc increases genomic instability, blocks differentiation, and is able to induce lymphoid and myeloid neoplasia, making it an attractive target for cancer treatment (8)(9)(10).…”
Section: Introductionmentioning
confidence: 99%