2018
DOI: 10.21037/amj.2018.08.05
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The proton pump inhibitors use and gastric cancer development: is it a real association?

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“…The pathway enrichment analysis performed in this study revealed that gastric acid secretion was the most significantly enriched pathway found in the tumoral tissue samples. Recent evidence has unveiled a role for protonpump inhibitors (PPIs) in the pathogenesis of GC due to their suppression of gastric acid section (23)(24)(25). A meta-analysis of observational studies on the effect of acid suppressive drugs on the development of GC found that H2 receptor blockers, H2 receptor antagonists (H2Ras), and PPIs significantly increased the risk for GC (26).…”
Section: Discussionmentioning
confidence: 99%
“…The pathway enrichment analysis performed in this study revealed that gastric acid secretion was the most significantly enriched pathway found in the tumoral tissue samples. Recent evidence has unveiled a role for protonpump inhibitors (PPIs) in the pathogenesis of GC due to their suppression of gastric acid section (23)(24)(25). A meta-analysis of observational studies on the effect of acid suppressive drugs on the development of GC found that H2 receptor blockers, H2 receptor antagonists (H2Ras), and PPIs significantly increased the risk for GC (26).…”
Section: Discussionmentioning
confidence: 99%