The proton treatment center at Loma Linda University Medical Center: Rationale for and description of its development

Slater, James M.; Archambeau, John O.; Miller, Daniel W.; Notarus, Michael I.; Preston, William; Slater, Jerry D.

doi:10.1016/0360-3016(92)90058-p

Cited by 151 publications

(68 citation statements)

References 26 publications

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“…[8] Siklotron da sabit bir enerjide sürekli ve yüksek enerjili ışın elde edilirken, [15] sinkrotronda farklı manyetik ve elektrik alanlarla farklı enerjilerde ışın elde edilir. [16] Siklotronda enerji azaltıcılarla ışının sınırı ve yoğunluğu modifiye edilerek herhangi bir derinlikteki tümör tedavi edilebilir. Enerji azaltıcılarında nötron kontaminasyonu problemi vardır ve çevre-de daha fazla koruma gerektirir.…”

Section: Fiziksel Ve Biyolojik Yönüunclassified

Role of proton therapy in the treatment of cancer

Hiçsönmez

2013

TJ Oncol

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Section: Fiziksel Ve Biyolojik Yönüunclassified

Role of proton therapy in the treatment of cancer

Hiçsönmez

2013

TJ Oncol

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“…In 1990, the modern era of particle therapy then began when the first hospitalbased proton therapy facility was opened at the Loma Linda University Medical Center ͑LLUMC͒ in California. 4 Now there are approximately 25 facilities around the world treating cancer patients with proton beams with more than 55,000 patients treated.…”

Section: Abbreviated History Of Proton Therapymentioning

confidence: 99%

Vision : Proton therapy

2009

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The first patients were treated with proton beams in 1955 at the Lawrence Berkeley Laboratory in California. In 1970, proton beams began to be used in research facilities to treat cancer patients using fractionated treatment regimens. It was not until 1990 that proton treatments were carried out in hospital-based facilities using technology and techniques that were comparable to those for modern photon therapy. Clinical data strongly support the conclusion that proton therapy is superior to conventional radiation therapy in a number of disease sites. Treatment planning studies have shown that proton dose distributions are superior to those for photons in a wide range of disease sites indicating that additional clinical gains can be achieved if these treatment plans can be reliably delivered to patients. Optimum proton dose distributions can be achieved with intensity modulated protons ͑IMPT͒, but very few patients have received this advanced form of treatment. It is anticipated widespread implementation of IMPT would provide additional improvements in clinical outcomes. Advances in the last decade have led to an increased interest in proton therapy. Currently, proton therapy is undergoing transitions that will move it into the mainstream of cancer treatment. For example, proton therapy is now reimbursed, there has been rapid development in proton therapy technology, and many new options are available for equipment, facility configuration, and financing. During the next decade, new developments will increase the efficiency and accuracy of proton therapy and enhance our ability to verify treatment planning calculations and perform quality assurance for proton therapy delivery. With the implementation of new multi-institution clinical studies and the routine availability of IMPT, it may be possible, within the next decade, to quantify the clinical gains obtained from optimized proton therapy. During this same period several new proton therapy facilities will be built and the cost of proton therapy is expected to decrease, making proton therapy routinely available to a larger population of cancer patients.

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“…A recent study showed that low-dose radiotherapy and whole-liver irradiation were ineffective, as they led to severe hepatic failure [9]. One study suggested that localized high-dose radiation therapy can improve the efficacy of radiation therapy [8], and ion beams can provide a better dose concentration then can photon beams [10,11]. Indeed, ion beams are considered a highly effective treatment for cancer due to their higher relative biological effectiveness (RBE) [12,13].…”

Section: Introductionmentioning

confidence: 99%

Preliminary study of apparent diffusion coefficient assessment after ion beam therapy for hepatocellular carcinoma

Kanamoto

Miyati

Terashima

et al. 2016

Radiol Phys Technol

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We evaluated the state of hepatocellular carcinoma (HCC) and the liver after ion beam therapy by analyzing the apparent diffusion coefficient (ADC). In this retrospective study, we evaluated 13 HCC lesions in 10 patients who underwent magnetic resonance imaging before and after therapy. Diffusion-weighted imaging was performed with use of b values of 0, 150, and 800 s/mm 2 . The ADC was determined for the tumor, irradiated liver, and normal liver. The maximum size of the tumor was measured, and reduction in tumor size was determined as a ratio of the maximum size of the diameter of the tumor. We compared the ADC before and after the therapy with the reduction in tumor size ratio. The reduction in tumor size ratio was compared with the ADCs of the tumors. The ADC of the tumor and the irradiated liver were significantly higher after therapy than before therapy. The ADC of the normal liver was not significantly different before and after therapy. The reduction ratio increased significantly (R = 0.73, P = 0.006) after therapy at the second follow-up when compared with after therapy at the first follow-up. No correlation was found between the reduction ratio and the ADC of the tumor in each follow-up. Inflammation of the liver occurs after treatment as a result of radiation doses from the ion beam, and the tumor reaches a state of necrosis. ADC value analysis provides a non-invasive assessment and yields focal information regarding the tumor and liver before and after ion beam therapy.

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The proton treatment center at Loma Linda University Medical Center: Rationale for and description of its development

Cited by 151 publications

References 26 publications

Role of proton therapy in the treatment of cancer

Role of proton therapy in the treatment of cancer

Vision : Proton therapy

Preliminary study of apparent diffusion coefficient assessment after ion beam therapy for hepatocellular carcinoma

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