The Prowess of Andrographolide as a Natural Weapon in the War against Cancer

Farooqı, Ammad Ahmad; Attar, Rükset; Sabitaliyevich, Uteuliyev Yerzhan; Alaaeddine, Nada; Sousa, Damião Pergentino de; Xu, Baojun; Cho, William C.

doi:10.3390/cancers12082159

Cited by 32 publications

(25 citation statements)

References 67 publications

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“…Andro possesses a remarkable inhibitory activity against inflammation, cancer, and viral infections ( Gupta et al, 2020 ). Current studies have revealed that it improves microcirculation and autophagy, while inhibits oxidative stress and cellular apoptotic process ( Yang et al, 2014 ; Geng et al, 2019 ; Farooqi et al, 2020 ; Li et al, 2020 ). However, there are few studies on Andro-induced autophagy especially in flap models.…”

Section: Discussionmentioning

confidence: 99%

Positive Effect of Andrographolide Induced Autophagy on Random-Pattern Skin Flaps Survival

et al. 2021

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Random-pattern skin flap replantation is generally used in the reconstruction of surgical tissues and covering a series of skin flap defects. However, ischemia often occurs at the flap distal parts, which lead to flap necrosis. Previous studies have shown that andrographolide (Andro) protects against ischemic cardiovascular diseases, but little is known about the effect of Andro on flap viability. Thus, our study aimed to building a model of random-pattern skin flap to understand the mechanism of Andro-induced effects on flap survival. In this study, fifty-four mice were randomly categorized into the control, Andro group, and the Andro+3-methyladenine group. The skin flap samples were obtained on postoperative day 7. Subsequently, the tissue samples were underwent a series of evaluations such as changes in the appearance of flap tissue, the intensity of blood flow, and neovascularization density of skin flap. In our study, the results revealed that Andro enhanced the viability of random skin flaps by enhancing angiogenesis, inhibiting apoptosis, and reducing oxidative stress. Furthermore, our results have also demonstrated that the administration of Andro caused an elevation in the autophagy, and these remarkable impact of Andro were reversed by 3-methyladenine (3-MA), the most common autophagy inhibitor. Together, our data proves novel evidence that Andro is a potent modulator of autophagy capable of significantly increasing random-pattern skin flap survival.

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Section: Discussionmentioning

confidence: 99%

Positive Effect of Andrographolide Induced Autophagy on Random-Pattern Skin Flaps Survival

et al. 2021

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“…Andrographolide is a diterpene lactone isolated from Andrographis paniculata and inhibits the development of different types of cancer by regulation of Wnt/β-catenin, mTOR, VEGF-mediated intracellular signaling and TRAIL-mediated apoptosis [ 171 , 172 ]. Its MM inhibitory properties were investigated together with the sesquiterpene lactone parthenolide [ 159 ].…”

Section: Resultsmentioning

confidence: 99%

Multiple Myeloma Inhibitory Activity of Plant Natural Products

Jöhrer

Ҫiҫek

2021

Cancers

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A literature search on plant natural products with antimyeloma activity until the end of 2020 resulted in 92 compounds with effects on at least one human myeloma cell line. Compounds were divided in different compound classes and both their structure–activity-relationships as well as eventual correlations with the pathways described for Multiple Myeloma were discussed. Each of the major compound classes in this review (alkaloids, phenolics, terpenes) revealed interesting candidates, such as dioncophyllines, a group of naphtylisoquinoline alkaloids, which showed pronounced and selective induction of apoptosis when substituted in position 7 of the isoquinoline moiety. Interestingly, out of the phenolic compound class, two of the most noteworthy constituents belong to the relatively small subclass of xanthones, rendering this group a good starting point for possible further drug development. The class of terpenoids also provides noteworthy constituents, such as the highly oxygenated diterpenoid oridonin, which exhibited antiproliferative effects equal to those of bortezomib on RPMI8226 cells. Moreover, triterpenoids containing a lactone ring and/or quinone-like substructures, e.g., bruceantin, whitaferin A, withanolide F, celastrol, and pristimerin, displayed remarkable activity, with the latter two compounds acting as inhibitors of both NF-κB and proteasome chymotrypsin-like activity.

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“…Factor -α (TNF -α) related Apoptosis inducing ligand (TRAIL -An important member of extrinsic apoptosis pathway) was significantly enhanced in various Human cancer 65 .…”

Section: Recent Work Demonstrates That Tumour Necrosismentioning

confidence: 99%

Untitled

2021

IJPSR

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Andrographolide is a labdane diterpenoid isolated from the leaves and roots of Andrographis paniculata Nees (Acanthaceae). Andrographolide is isolated by various processes and the simple method is the maceration process. It is bitter in taste and used as hepatoprotective, cholinergic, antispasmodic, stomachic, anthelmentic, alterative, blood purifier, and febrifuge. It promotes the secretion of bile in the liver and is used in jaundice, torpid liver, cold and upper respiratory tract infection. It is also used in the treatment of snake bites and is found to be more effective than the anti-snake venom generally used. Hesperidin is a flavanone glycoside isolated from the peels of Citrus sinensis (Rutaceae). Hesperidin plays an important role in plant defense mechanisms. Hesperidin is commonly isolated by two laboratory processes maceration and continuous percolation method. The major pharmacological actions of the hesperidin reported are anti-hyperlipidemic, cardioprotective, antihypertensive, antidiabetic, antioxidant, anti-inflammatory, and antiartherogenic activity. However, what is noteworthy about this paper is highlighting the evidence-based overview on the chemical and physical nature of Andrographolide and Hesperidin along with a brief account on the plants from which they are isolated, the extraction and isolation procedures of the above chemical constituents, their physical properties and structure along with their pharmacological properties are also discussed.

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The Prowess of Andrographolide as a Natural Weapon in the War against Cancer

Cited by 32 publications

References 67 publications

Positive Effect of Andrographolide Induced Autophagy on Random-Pattern Skin Flaps Survival

Positive Effect of Andrographolide Induced Autophagy on Random-Pattern Skin Flaps Survival

Multiple Myeloma Inhibitory Activity of Plant Natural Products

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