The psychogenetically selected Roman high- and low-avoidance rat lines: A model to study the individual vulnerability to drug addiction

Giorgi, Osvaldo; Piras, Giovanna; Corda, Maria Giuseppa

doi:10.1016/j.neubiorev.2006.07.008

Cited by 119 publications

(120 citation statements)

References 103 publications

(161 reference statements)

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“…Moreover, the relationship between monoamine levels and impulsivity depends on the particular impulsive behavior evaluated (Winstanley et al, 2006, for review). Convergent evidence suggests that monoaminergic (at least DA and 5-HT) functional differences in the mesolimbic-mesocortical systems and related areas mediate the impulsivity-related behavioral traits that distinguish the Roman rat lines/ strains, including differential sensitivity to the effects of (and preference for) drugs of abuse (for reviews, see Charnay et al, 1995;Driscoll et al, 1980;Fattore et al, 2009;Fernández-Teruel et al, 2002a;Giorgi et al, 1994Giorgi et al, , 2003Giorgi et al, , 2007Guitart-Masip et al, 2006a, b, 2008aKulikov et al, 1995;Lecca et al, 2004). Collectively, the neurochemical findings reported in these studies suggest a relatively increased function (or tone) of DA and 5-HT neurotransmission in the RHA rat line/strain relative to RLA animals.…”

Section: Increased Adjunctive Drinking Acquisition In Rha-i Ratsmentioning

confidence: 99%

“…Two phenotypes with different emotional and motivational profiles have been developed through bidirectional selection and breeding of the Roman high-(RHA) and low-avoidance (RLA) rat lines/ strains (outbred or inbred, respectively), selected for rapid (RHA) vs extremely poor (RLA) acquisition of two-way active avoidance in the shuttle-box (Broadhurst and Bignami, 1965;Driscoll and Bättig, 1982) (for reviews, see Driscoll et al, 1990Driscoll et al, , 1998Driscoll et al, , 2009Escorihuela et al, 1995Escorihuela et al, , 1999Fernández-Teruel et al, 1997;Giorgi et al, 2007;Steimer and Driscoll, 2005). These lines/strains show consistent differences in sensation/novelty seeking and in stress/anxiety endocrine and behavioral responses when confronted with novel environments (ie, intended to measure anxiety, emotionality, fearfulness, or novelty seeking), such as the open-field test (Aubry et al, 1995;Carrasco et al, 2008;Escorihuela et al, 1999;Gentsch et al, 1991), elevated plus maze (Escorihuela et al, 1999;Steimer and Driscoll, 2003), elevated zero-maze (López-Aumatell et al, 2009b), blackwhite box test, dark-light open-field test, dark-light hexagonal tunnel maze (Fernández-Teruel et al, 2002b;Steimer and Driscoll, 2005), and hole-board test (Escorihuela et al, 1999;Fernández-Teruel et al, 1992).…”

Section: Introductionmentioning

confidence: 99%

“…RHA rats tend to be novelty/sensation seekers with relatively low HPA axis activation (Driscoll et al, 1998(Driscoll et al, , 2009. Moreover, these differences occur with individual differences in vulnerability to drug addiction, manifested as behavioral and neurochemical responses to different drugs of abuse such as ethanol, morphine, and cocaine (Fattore et al, 2009;Giorgi et al, 2007). Abundant evidence implicates dopaminergic mechanisms in these differences.…”

Section: Introductionmentioning

confidence: 99%

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Impulsivity Characterization in the Roman High- and Low-Avoidance Rat Strains: Behavioral and Neurochemical Differences

Moreno

Cardona

Gómez

et al. 2010

Neuropsychopharmacol

134

106

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The selective breeding of Roman high-(RHA) and low-avoidance (RLA) rats for rapid vs extremely poor acquisition of active avoidance behavior in a shuttle-box has generated two phenotypes with different emotional and motivational profiles. The phenotypic traits of the Roman rat lines/strains (outbred or inbred, respectively) include differences in sensation/novelty seeking, anxiety/fearfulness, stress responsivity, and susceptibility to addictive substances. We designed this study to characterize differences between the inbred RHA-I and RLA-I strains in the impulsivity trait by evaluating different aspects of the multifaceted nature of impulsive behaviors using two different models of impulsivity, the delay-discounting task and five-choice serial reaction time (5-CSRT) task. Previously, rats were evaluated on a schedule-induced polydipsia (SIP) task that has been suggested as a model of obsessive-compulsive disorder. RHA-I rats showed an increased acquisition of the SIP task, higher choice impulsivity in the delay-discounting task, and poor inhibitory control as shown by increased premature responses in the 5-CSRT task. Therefore, RHA-I rats manifested an increased impulsivity phenotype compared with RLA-I rats. Moreover, these differences in impulsivity were associated with basal neurochemical differences in striatum and nucleus accumbens monoamines found between the two strains. These findings characterize the Roman rat strains as a valid model for studying the different aspects of impulsive behavior and for analyzing the mechanisms involved in individual predisposition to impulsivity and its related psychopathologies.

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Section: Increased Adjunctive Drinking Acquisition In Rha-i Ratsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Impulsivity Characterization in the Roman High- and Low-Avoidance Rat Strains: Behavioral and Neurochemical Differences

Moreno

Cardona

Gómez

et al. 2010

Neuropsychopharmacol

134

106

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“…These findings suggest that RLA rats represent a valid genetic model to investigate the neural circuitry and molecular mechanisms underlying stress‐induced depression and, more specifically, to study depression associated with anxiety symptoms. Multidisciplinary studies aimed at identifying the central neuronal circuits involved in the above‐mentioned behavioral differences across the Roman lines have shown that their divergent phenotypic traits may be accounted for, at least in part, by differences in the functional responses of their central monoaminergic systems (D'Angiò, Serrano, Driscoll, & Scatton, 1988; Giorgi, Lecca, Piras, Driscoll, & Corda, 2003; Giorgi, Piras, Lecca, & Corda, 2005; Giorgi et al., 1994; Giorgi, Piras, et al., 2003 Giorgi et al., 2007, 2015; Lecca, Piras, Driscoll, Giorgi, & Corda, 2004; Sanna et al., 2015; Tournier et al., 2013). …”

Section: Introductionmentioning

confidence: 99%

Expression of BDNF and trkB in the hippocampus of a rat genetic model of vulnerability (Roman low‐avoidance) and resistance (Roman high‐avoidance) to stress‐induced depression

et al. 2017

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IntroductionThe selective breeding of Roman High‐ (RHA) and Low‐Avoidance (RLA) rats for, respectively, rapid versus poor acquisition of the active avoidance response has generated two distinct phenotypes differing in many behavioral traits, including coping strategies to aversive conditions. Thus, RLA rats are considered as a genetic model of vulnerability to stress‐induced depression whereas RHA rats are a model of resilience to that trait. Besides the monoamine hypothesis of depression, there is evidence that alterations in neuronal plasticity in the hippocampus and other brain areas are critically involved in the pathophysiology of mood disorders.Materials and MethodsWestern blot (WB) and immunohistochemistry were used to investigate the basal immunochemical occurrence of brain‐derived neurotrophic factor (BDNF) and its high‐affinity tyrosine‐kinase receptor trkB in the dorsal and ventral hippocampus of adult RHA and RLA rats.Results WB analysis indicated that the optical density of BDNF‐ and trkB‐positive bands in the dorsal hippocampus is, respectively, 48% and 25% lower in RLA versus RHA rats. Densitometric analysis of BDNF‐ and trkB‐like immunoreactivity (LI) in brain sections showed that BDNF‐LI is 24% to 34% lower in the different sectors of the Ammon's horn of RLA versus RHA rats, whereas line‐related differences are observed in the dentate gyrus (DG) only in the ventral hippocampus. As for trkB‐LI, significant differences are observed only in the dorsal hippocampus, where density is 23% lower in the DG of RLA versus RHA rats, while no differences across lines occur in the Ammon's horn.ConclusionThese findings support the hypothesis that a reduced BDNF/trkB signaling in the hippocampus of RLA versus RHA rats may contribute to their more pronounced vulnerability to stress‐induced depression.

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“…The Roman high-(RHA) and low-avoidance (RLA) rat lines were selected for, respectively, rapid vs poor acquisition of two-way active avoidance in the shuttle-box (Broadhurst and Bignami, 1965;Driscoll and Bättig, 1982;Fernández-Teruel et al, 2002;Giorgi et al, 2007). Several relevant behavioral and neurochemical differences between the two lines have been identified along the selective breeding process.…”

Section: Introductionmentioning

confidence: 99%

The Roman High- and Low-Avoidance Rat Lines Differ in the Acquisition, Maintenance, Extinction, and Reinstatement of Intravenous Cocaine Self-Administration

Fattore

Piras

Corda

et al. 2008

Neuropsychopharmacol

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The selective breeding of Roman high-(RHA) and low-avoidance (RLA) rats for, respectively, rapid vs extremely poor acquisition of avoidant behavior in a shuttlebox has produced two phenotypes that differ in temperament traits, in mesocortical/mesolimbic dopamine system function, and in the behavioral and neurochemical responses to the acute and repeated administration of psychostimulants and opiates. The phenotypic traits of the RHA line predict higher susceptibility, compared with RLA rats, to the reinforcing properties of addictive substances like cocaine. The present study was designed to compare the acquisition, maintenance, reinstatement of drugseeking after long-term extinction, and reacquisition of intravenous cocaine self-administration (SA) behavior in the Roman lines. Compared with RLA rats, the rates of responding during cocaine SA acquisition were higher, extinction from cocaine SA was prolonged, and drug-induced reinstatement of cocaine-seeking behavior was more robust in RHA rats. Moreover, only RHA rats reacquired extinguished lever-pressing activity when a low reinforcing dose of cocaine was available. These findings are consistent with the view that subjects with genetically determined high responsiveness to the acute and chronic (ie, sensitizing) effects of psychostimulants, such as RHA rats, also display a higher propensity to self -administer cocaine. Further comparative studies in the Roman lines, using SA paradigms that distinguish mere drug-taking from the compulsive and uncontrolled drug use that characterizes addiction in humans, may eventually help to characterize the relationships among genotype, temperament traits, and neurobiological mechanisms involved in the individual vulnerability to cocaine addiction.

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The psychogenetically selected Roman high- and low-avoidance rat lines: A model to study the individual vulnerability to drug addiction

Cited by 119 publications

References 103 publications

Impulsivity Characterization in the Roman High- and Low-Avoidance Rat Strains: Behavioral and Neurochemical Differences

Impulsivity Characterization in the Roman High- and Low-Avoidance Rat Strains: Behavioral and Neurochemical Differences

Expression of BDNF and trkB in the hippocampus of a rat genetic model of vulnerability (Roman low‐avoidance) and resistance (Roman high‐avoidance) to stress‐induced depression

The Roman High- and Low-Avoidance Rat Lines Differ in the Acquisition, Maintenance, Extinction, and Reinstatement of Intravenous Cocaine Self-Administration

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