AimThis study examined the interplay among spirituality, self‐efficacy and resilience in this context.DesignA cross‐sectional study.MethodA total of 178 parents of children newly diagnosed with diabetes mellitus; the instruments used for data collection were the Parental Self‐Efficacy Scale for Diabetes Management, The Arabic version of The Walsh Family Resilience Questionnaire and the Spiritual Perspective Scale.ResultsSelf‐efficacy had a significant positive direct effect on family resilience. Spirituality also had a significant positive direct effect on family resilience. Additionally, self‐efficacy had a significant positive indirect effect on family resilience through its effect on spirituality.ConclusionThe findings underscore the impact of spirituality and self‐efficacy on a family resilience.Implications for the ProfessionNurses should prioritise self‐care and personal reflection to enhance their spiritual well‐being. This can help them better understand and empathise with their patients' spiritual needs, allowing for more effective and compassionate care.ImpactUpon the initial diagnosis of diabetes in a child, parents undergo a profound emotional and psychological upheaval. They are faced with the daunting task of managing their child's condition while also coping with their feelings of distress, uncertainty and fear. Amidst these challenges, factors such as self‐efficacy and resilience play pivotal roles in determining how parents adapt to and navigate this new reality.Nurses can use spiritual care to give parents a sense of meaning, purpose and hope, bolstering their self‐efficacy and resilience.Reporting MethodThe relevant reporting method has been adhered to, that is, STROBE.Patient or Public ContributionIn our research, data collection is assisted by nurses working in community‐based settings.