“…Although more work is needed to fully understand the mechanisms of therapeutic action, the beneficial effects of these substances appear to be associated with the intensity of certain types of acute psychedelic effects (e.g., mystical-type phenomena, psychological insight) during these experiences in both healthy (Griffiths et al, 2008(Griffiths et al, , 2011Barrett et al, 2015) and clinical (Ross et al, 2016;Griffiths et al, 2008;Griffiths et al, 2011;Roseman, Nutt, & Carhart-Harris, 2018;Davis et al, 2018;Garcia-Romeu et al, 2019) populations. Potential mediators of psychedelic effects on therapeutic outcomes have been suggested, including changes in the entropy of brain network connectivity (Carhart-Harris et al, 2014), the importance of awe/ego dissolution (Hendricks, 2018;Preller & Vollenweider, 2018); and the possible role of changes in psychological flexibility following a psychedelic experience (Sabucedo, 2017;Kuypers et al, 2016;Walsh & Thiessen, 2018).…”