Introduction. Cancer patients often experience significant psychological stress, which can negatively impact their medication adherence. This study aimed to evaluate and minimize psychological stress to enhance medication adherence among cancer patients by implementing integrative oncology techniques. Material and methods. The study included 63 male and female participants diagnosed with head and neck, cervical, breast, and prostate cancers, who were followed for six months. Various scales were used to assess the psychological status of the patients, including the distress thermometer, the Hospital Anxiety and Depression Scale (HADS), and the Functional Assessment of Cancer Therapy (FACT) questionnaire. Integrative oncology techniques, including yoga, meditation, patient counseling, and rehabilitation, were employed to reduce stress and improve patient outcomes. Results. The results showed a significant reduction in anxiety and depression levels among patients after implementing integrative oncology techniques. The quality of life (QoL) scores improved in patients with different cancer types, such as head and neck, cervical, breast, and prostate cancers, following the intervention. Moreover, distress levels decreased in patients who received effective patient counseling. Conclusions. In conclusion, these findings suggest that integrative oncology techniques can effectively reduce psychological stress and enhance medication adherence in cancer patients, ultimately improving their overall well-being and treatment outcomes.