The Psychological Processes of Classic Psychedelics in the Treatment of Depression: A Systematic Review Protocol

Johansen, Lauren; Liknaitzky, Paul; Nedeljkovic, Maja; Mastin-Purcell, Lisa; Murray, Greg

doi:10.21203/rs.3.rs-121894/v1

Cited by 1 publication

(1 citation statement)

References 47 publications

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“…In recent years, there has been rekindled interest in the potential of CPs, particularly psilocybin, as possible therapeutic agents for treatment-resistant depression and other psychiatric disorders. This work has added to longstanding evidence that CPs can chronically alleviate depressive symptomatology in a dose-dependent manner mediated by the intensity of the experience [4][5][6][7].…”

Section: Introductionmentioning

confidence: 94%

The classic psychedelic DOI induces a persistent desynchronized state in medial prefrontal cortex

Olson

Bartlett

Sonneborn

et al. 2023

Preprint

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Administration or consumption of classic psychedelics (CPs) leads to profound changes in experience which are often described as highly novel and meaningful. They have shown substantial promise in treating depressive symptoms and may be therapeutic in other situations. Although research suggests that the therapeutic response is correlated with the intensity of the experience, the neural circuit basis for the alterations in experience caused by CPs requires further study. The medial prefrontal cortex (mPFC), where CPs have been shown to induce rapid, 5-HT2A receptor-dependent structural and neurophysiological changes, is believed to be a key site of action. To investigate the acute neural circuit changes induced by CPs, we recorded single neurons and local field potentials in the mPFC of freely behaving mice after administration of the 5-HT2A/2C receptor-selective CP, 2,5-Dimethoxy-4-iodoamphetamine (DOI). We segregated recordings into active and rest periods in order to examine cortical activity during desynchronized (active) and synchronized (rest) states. We found that DOI induced a robust decrease in low frequency power and decoupled rhythmic activity from neural population dynamics when animals were at rest, attenuating the usual synchronization that occurs during less active behavioral states. DOI also increased broadband gamma power and suppressed activity in fast-spiking neurons in both active and rest periods. Together, these results show that the CP DOI induces persistent desynchronization in mPFC, including during rest when mPFC typically exhibits more synchronized activity. This shift in cortical dynamics may in part underlie the longer-lasting effects of CPs on plasticity, and may be critical to their therapeutic properties.

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Section: Introductionmentioning

confidence: 94%