The Psychosocial Impact on High-Risk PregnantWomen of a Noninvasive Prenatal Diagnostic Test

Zamerowski, Suzanne T.; Lumley, Mark A.; Arreola, RaoulA.; Dukes, KimDukes; Khan, Aijaz Ahmed; Sullivan, Lisa M.

doi:10.1159/000020904

Cited by 8 publications

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References 8 publications

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“…Yet, relatively little is known about women's desires for such testing, how they would respond to normal or abnormal test results, and the sociodemographic and attitudinal factors that might explain women's responses to test results. 4,5 Previously, in the related literature on second-trimester maternal serum alpha fetoprotein screening (MSAFP), researchers have examined women's attitudes and factors that predict responses. Based on a comprehensive literature review, Jorgensen 6,7 proposed a conceptual model of the predictors of women's attitudes toward prenatal screening and diagnosis.…”

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Favorable attitudes toward testing for chromosomal abnormalities via analysis of fetal cells in maternal blood

Zamerowski

Lumley

Arreola

et al. 2001

Genetics in Medicine

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Purpose: The NICHD Fetal Cell Isolation Study (NIFTY) was a multicentered project to isolate fetal cells from maternal blood to detect fetal chromosomal abnormalities. The project included a psychosocial component, which is the basis of this article. We examined the attitudes of high-risk pregnant women toward the availability of a maternal blood test to identify fetal chromosomal abnormalities, how women would respond to hypothetical normal and abnormal maternal blood testing results, and the factors associated with a woman's preference to have an invasive procedure in response to a normal maternal blood test. Methods: High-risk pregnant women (N ϭ 854) planning to have prenatal diagnostic invasive testing (amniocentesis or chorionic villus sampling) completed a survey. Results: The women highly favored maternal blood testing. Almost all women would seek invasive testing after an abnormal blood test. Only half of the women would seek invasive testing after a normal blood test; these women were older, more willing to terminate their pregnancy, and valued the increased accuracy of invasive testing more highly than women who would not have invasive testing after a normal maternal blood test. Conclusions:

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confidence: 99%

Favorable attitudes toward testing for chromosomal abnormalities via analysis of fetal cells in maternal blood

Zamerowski

Lumley

Arreola

et al. 2001

Genetics in Medicine

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Prenatal diagnosis for women aged 37 years and over: to have or not to have

et al. 2001

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Forty percent of pregnant women aged 37 years and over do not have prenatal diagnosis despite being eligible for a free test. The present study aimed to determine how often, and which, untested women were making a choice about this, how many declined an offer and why. A questionnaire was given to untested women, aged 37 years and over, at no less than 24 weeks gestation. A total of 375 (81.5%) women declined, 72 (16%) were not offered a test and 13 presented too late antenatally. There was a three-fold increased likelihood (OR 3.10 95% CI 1.44, 6.65) of no offer for urban non-English speaking background women, compared with the reference group (metropolitan, English speaking). Unpartnered women were also significantly less likely to receive an offer (OR 3.18, 95% CI 1.19, 8.46). Risk to the baby was the main reason for declining. When offered non-invasive prenatal screening, most decliners of prenatal diagnosis accepted, even those who declined because they were opposed to abortion. We estimate that overall 33% of older pregnant women were being offered and declining amniocentesis and/or chorion villus sampling (CVS). Only 6% were not offered a test, but this small proportion is over-represented by minority groups who must be given equal opportunity to make this choice.

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Fetal gender and aneuploidy detection using fetal cells in maternal blood: analysis of NIFTY I data

et al. 2002

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The sensitivity of aneuploidy detection using fetal cell analysis from maternal blood is comparable to single marker prenatal serum screening, but technological advances are needed before fetal cell analysis has clinical application as part of a multiple marker method for non-invasive prenatal screening. The limitations of the present study, i.e. multiple processing protocols, are being addressed in the ongoing study.

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The Psychosocial Impact on High-Risk PregnantWomen of a Noninvasive Prenatal Diagnostic Test

Cited by 8 publications

References 8 publications

Favorable attitudes toward testing for chromosomal abnormalities via analysis of fetal cells in maternal blood

Favorable attitudes toward testing for chromosomal abnormalities via analysis of fetal cells in maternal blood

Prenatal diagnosis for women aged 37 years and over: to have or not to have

Fetal gender and aneuploidy detection using fetal cells in maternal blood: analysis of NIFTY I data

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