The psychostimulant and rewarding effects of cocaine in histidine decarboxylase knockout mice do not support the hypothesis of an inhibitory function of histamine on reward

Brabant, Christian; Quertemont, Étienne; Anaclet, Christelle; Lin, Jian‐Sheng; Ohtsu, Hiroshi; Tirelli, Ezio

doi:10.1007/s00213-006-0603-0

Cited by 31 publications

(29 citation statements)

References 47 publications

(64 reference statements)

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“…The HDC KO mice were less activated by acute ethanol administration than the WT mice, in accordance with a previous study showing diminished response of HDC KO mice to cocaine (Brabant et al 2007). Data from the place conditioning trials also confirmed the lack of ethanol stimulation in HDC KO mice.…”

Section: Discussionsupporting

confidence: 89%

“…Furthermore, H1 receptor antagonists potentiate morphine-induced conditioned place preference (CPP) in rats and mice (Suzuki et al 1995(Suzuki et al , 1996 and maintain selfadministration when substituted for cocaine in monkeys (Beardsley and Balster 1992). In contrast, histidine decarboxylase knockout (HDC KO) mice that lack the histamine synthesizing enzyme are less stimulated by cocaine than wild-type (WT) animals (Brabant et al 2007). Furthermore, H3 receptor antagonists that increase the release of histamine enhance self-administration of methamphetamine (Munzar et al 2004) and bring out cocaine-induced place preference with a dose of cocaine that does not induce reward by itself (Brabant et al 2005).…”

Section: Introductionmentioning

confidence: 96%

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Histamine and H3 receptor-dependent mechanisms regulate ethanol stimulation and conditioned place preference in mice

et al. 2009

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 96%

Histamine and H3 receptor-dependent mechanisms regulate ethanol stimulation and conditioned place preference in mice

et al. 2009

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“…cocaine selfadministration (Rocha et al, 2002) and intracranial self-stimulation studies (Malanga et al, 2007). Meta-analysis of multiple studies showed that single housing does not affect the development of cocaine CPP in rats (Bardo et al, 1995), and cocaine CPP has been demonstrated in singly-housed C57Bl/6J (Szumlinski et al, 2002) and 129/Sv mice (Brabant et al, 2007). On days 2-4 each mouse was handled for 5 minutes daily, and on days 5-7 mice were handled for five minutes daily and injected with saline vehicle in their home cage.…”

Section: Conditioned Place Preference (Cpp)mentioning

confidence: 99%

Prenatal exposure to cocaine alters the development of conditioned place-preference to cocaine in adult mice

Malanga

Pejchal

Kosofsky

2007

Pharmacology Biochemistry and Behavior

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As addiction is increasingly formulated as a developmental disorder, identifying how early developmental exposures influence later responses to drugs of abuse is important to our understanding of substance abuse neurobiology. We have previously identified behavioral changes in adult mice following gestational exposure to cocaine that differ when assessed with methods employing contingent and non-contingent drug administration. We sought to clarify this distinction using a Pavlovian behavioral measure, conditioned place-preference. Adult mice exposed to cocaine in utero (40 or 20 mg/kg/day), vehicle and pair-fed controls were place-conditioned to either cocaine (5 mg/kg or 20 mg/kg, i.p.) or saline injections. The development of conditioned place-preference to cocaine was impaired in mice exposed to cocaine in utero, and was abolished by fetal malnutrition. A context-specific place-aversion to vehicle but not cocaine injection was observed in prenatally cocaine-exposed mice. Locomotor behavior did not differ among prenatal treatment groups. We conclude that early developmental exposure to cocaine may diminish the subsequent rewarding effects of cocaine in adulthood measured with classical conditioning techniques, and that this is not due to changes in locomotor behavior. Sensitivity to acute stress is also altered by prenatal cocaine exposure, consistent with earlier findings in this model.

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“…2) and morphine (Gong et al, 2010) is stronger in HDC KO mice. However, no difference for cocaine reward was found in the CPP model between HDC KO and WT mice (Brabant et al, 2007). This discrepancy could be explained by the different CPP designs.…”

Section: Histamine In Mouse Models Of Addictionmentioning

confidence: 86%

“…Although the CPP responses differ for ethanol and cocaine, the HDC KO mice show decreased locomotor stimulation in response to ethanol (Nuutinen et al, 2010) and cocaine (Brabant et al, 2007). These findings suggest that histamine is needed for the acute stimulation by drugs of abuse, whereas the reward and reinforcement might be inhibited by neuronal histamine.…”

Section: Histamine In Mouse Models Of Addictionmentioning

confidence: 89%

Histamine and H₃Receptor in Alcohol-Related Behaviors

Panula¹,

Nuutinen²

2010

J Pharmacol Exp Ther

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Data from rat models for alcohol preference and histidine decarboxylase knockout (HDC KO) mice suggest that brain histamine regulates alcohol-related behaviors. Histamine levels are higher in alcohol-preferring than in alcohol-nonpreferring rat brains, and expression of histamine H 3 receptor (H 3 R) is different in key areas for addictive behavior. H 3 R inverse agonists decrease alcohol responding in one alcohol-preferring rat line. Conditioned place preference induced by alcohol is stronger in HDC KO mice than in control mice. The HDC KO mice display a weaker stimulatory response to acute alcohol than the wildtype (WT) mice. In male inbred C57BL/6 mice the H 3 R antagonist ciproxifan inhibits ethanol-evoked stimulation of locomotor activity. Ciproxifan also potentiates the ethanol reward, but does not alone result in the development of place preference.At least in one rat model developed to study alcohol sensitivity high histamine levels are characteristic of the alcohol-insensitive rat line, and lowering brain histamine with a HDC inhibitor increases alcohol sensitivity in the tilting plane test. However, the motor skills of HDC KO mice do not seem to differ from those of the WT mice. Current evidence suggests that the histaminergic system is involved in the regulation of place preference behavior triggered by alcohol, possibly through an interaction with the mesolimbic dopamine system. Histamine may also interact with dopamine in the regulation of the corticostriato-pallido-thalamo-cortical motor pathway and cerebellar mechanisms, which may be important in different motor behaviors beyond alcohol-induced motor disturbances. H 3 R ligands may have significant effects on alcohol addiction. Rat Models of Alcohol-Related BehaviorsSeveral inbred and outbred rat lines with different alcohol preferences have been developed and reported (for a review, see Sinclair et al., 1989;Sommer et al., 2006). These include the high alcohol-preferring (HAP) and low alcohol-preferring (LAP) rats (Kitanaka et al., 2004), inbred alcohol-preferring and nonpreferring rats (McBride et al., 2010), and outbred alko alcohol (AA) and alko nonalcohol (ANA) rats (Sinclair et al., 1989;Sommer et al., 2006). A summary of rat and mouse models used in alcohol research is shown in Table 1.The AA and ANA rat lines were among the first lines produced using a bidirectional selection method (Eriksson, 1968) for alcohol preference, and these rats have now been maintained beyond the 100th generation (Sommer et al., 2006). The AA rats have higher levels of dopamine in several brain regions, including striatum and limbic forebrain, than the ANA rats (Ahtee and Eriksson, 1975), and tyrosine hydroxylase activity is also 42% higher in AA than ANA rats (Pispa et al., 1986). The levels of noradrenaline are also higher in AA rats than in ANA rats in the cortex and limbic areas (Ahtee and Eriksson, 1975). Noradrenaline turnover also appears higher in AA rats, because the levels of 3-methoxy-4-hydroxy-phenylglycol are higher in AA rats (Sommer et al.,...

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The psychostimulant and rewarding effects of cocaine in histidine decarboxylase knockout mice do not support the hypothesis of an inhibitory function of histamine on reward

Abstract: Our data confirm previous results demonstrating that HDC KO mice show reduced exploratory behaviors. However, contrary to the hypothesis that histamine plays an inhibitory role in reward, histamine-deficient mice were not more responsive to the psychostimulant effects of cocaine.

Cited by 31 publications

References 47 publications

Histamine and H3 receptor-dependent mechanisms regulate ethanol stimulation and conditioned place preference in mice

Histamine and H3 receptor-dependent mechanisms regulate ethanol stimulation and conditioned place preference in mice

Prenatal exposure to cocaine alters the development of conditioned place-preference to cocaine in adult mice

Histamine and H₃Receptor in Alcohol-Related Behaviors

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The psychostimulant and rewarding effects of cocaine in histidine decarboxylase knockout mice do not support the hypothesis of an inhibitory function of histamine on reward

Abstract: Our data confirm previous results demonstrating that HDC KO mice show reduced exploratory behaviors. However, contrary to the hypothesis that histamine plays an inhibitory role in reward, histamine-deficient mice were not more responsive to the psychostimulant effects of cocaine.

Cited by 31 publications

References 47 publications

Histamine and H3 receptor-dependent mechanisms regulate ethanol stimulation and conditioned place preference in mice

Histamine and H3 receptor-dependent mechanisms regulate ethanol stimulation and conditioned place preference in mice

Prenatal exposure to cocaine alters the development of conditioned place-preference to cocaine in adult mice

Histamine and H3Receptor in Alcohol-Related Behaviors

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Histamine and H₃Receptor in Alcohol-Related Behaviors