The pterocellins, bioactive alkaloids from the marine bryozoan Pterocella vesiculosa

Prinsep, Michèle R.; Yao, Biao; Nicholson, Brian K.; Gordon, Dennis P.

doi:10.1007/s11101-004-6146-2

Cited by 20 publications

(33 citation statements)

References 11 publications

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“…Cribrimorphs are likely non-monophyletic (see Gordon [47]) and, thus, dense taxon sampling of this group is highly recommended for future phylogenetic studies. Three cribrimorph species belonging to two abovementioned superfamilies have so far been analyzed for bioactive compounds: Euthyroides episcopalis [48,49], Pterocella vesiculosa [50][51][52] and Paracribricellina cribraria [53,54]. [25] and Nesnidal et al [26], and the interrelationships within the Bryozoa based on Knight et al [39], Laumer et al [25], Nesnidal et al [26], and Waeschenbach et al [24,27].…”

Section: Phylogenymentioning

confidence: 99%

The Phylum Bryozoa: From Biology to Biomedical Potential

et al. 2020

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Less than one percent of marine natural products characterized since 1963 have been obtained from the phylum Bryozoa which, therefore, still represents a huge reservoir for the discovery of bioactive metabolites with its ~6000 described species. The current review is designed to highlight how bryozoans use sophisticated chemical defenses against their numerous predators and competitors, and which can be harbored for medicinal uses. This review collates all currently available chemoecological data about bryozoans and lists potential applications/benefits for human health. The core of the current review relates to the potential of bryozoan metabolites in human diseases with particular attention to viral, brain, and parasitic diseases. It additionally weighs the pros and cons of total syntheses of some bryozoan metabolites versus the synthesis of non-natural analogues, and explores the hopes put into the development of biotechnological approaches to provide sustainable amounts of bryozoan metabolites without harming the natural environment.

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Section: Phylogenymentioning

confidence: 99%

The Phylum Bryozoa: From Biology to Biomedical Potential

et al. 2020

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“…Pterocellins A-F are a series of alkaloids based on a 4-pyridone group and a pyridine group bound together through a five membered ring which appear to be unique to the cheilostome Pterocella vesiculosa [57,58]. Specifically, pterocellins A and B were isolated from an organic extract of this bryozoan species from the Hen and Chicken Islands (off the North Island of New Zealand).…”

Section: Pterocellinsmentioning

confidence: 99%

“…Only pterocellin A was tested in preliminary in vivo antitumour evaluation in the mouse hollow fibre assay given the other compound had similar cytotoxicity profile. The results showed it was not effective, being discarded for the next stage of testing [27]. Also, this alkaloid was cytotoxic to Hela human cervical cancer cells, with an IC50 of 886 ng/ml [59].…”

Section: Pterocellinsmentioning

confidence: 99%

The Understudied Phylum Bryozoa as a Promising Source of Anticancer Drugs

Figuerola¹,

Ávila²

2019

Preprint

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Recent advances in sampling and novel techniques in drug synthesis and isolation have promoted the discovery of anticancer agents from marine organisms to combat this major threat to public health worldwide. Bryozoans, filter-feeding, sessile aquatic invertebrates often characterized by a calcified skeleton, are an excellent source of pharmacologically interesting compounds including well-known chemical classes such as alkaloids and polyketides. This review covers the literature for secondary metabolites isolated from marine cheilostome and ctenostome bryozoans that have shown potential as cancer drugs. Moreover, we highlight examples such as bryostatins, the most known class of marine-derived compounds from this animal phylum, which is advancing through anticancer clinical trials due to their low toxicity and antineoplastic activity. The bryozoan antitumour compounds discovered until now show a wide range of chemical diversity and biological activities. Therefore, more research focusing on the isolation of secondary metabolites with potential anticancer properties from bryozoans and other overlooked taxa covering wider geographic areas is needed for an efficient bioprospecting of natural products.

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“…Many groups of invertebrates produce specific substances that serve as defensive agents against predators, parasites, and infections and/or chemicals for intraspecific and interspecific communication. Some of these compounds have interesting properties which could potentially be exploited in pharmacology (Prinsep, Yao, Nicholson, & Gordon, 2004). Organic compounds from marine organisms have been used extensively in the treatment of many diseases and perform as important compounds both in their natural form and as templates for synthetic modifications (Hrckova & Velebny, 2013).…”

Section: Introductionmentioning

confidence: 99%

Effect of bryostatin-1 as an anthelmintic drug on adult Syphacia muris infection in rats

Harras

Mona

Abdalla

et al. 2017

JoBAZ

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Background: The fact that many laboratory rodent colonies were found to be parasite contaminated suggests a need for eradication to improve their quality for research and testing. However, the most anthelmintic are poisonous, and their application always entails some hazards to the host and interferes with the interpretation of the final results. The use of bryostatin as a potential anthelmintic drug is still a matter of controversy. Therefore, the present work was designed to examine the naturally extracted product bryostatin-1 from a marine bryozoan as a possible anthelmintic agent against Pinworms Syphacia muris. Results: Light and scanning electron microscopy revealed normal appearance of worms collected from the infected groups with S. muris and untreated by bryostatin-1, while those collected from the bryostatin-1 treated rats revealed drastic morphological changes in the mouth parts, anus, and cuticle of all treated worms. Significant effects of bryostatin-1 on Syphacia infection were also detected in rats regarding the final body weights, average food consumption, and organ weights. Moreover, the drug has also improved the serum biochemical changes significantly in the infected rats nearly to the normal levels. Conclusions: The study has provided morphological evidence of obvious effect of bryostatin-1 on the movement and feeding behavior of the parasite that lead to consequent weakness and death as well as improvement of the biochemical changes in the infected rats. The present study concluded that bryostatin-1 can be used as anthelmintic agent, although further studies are needed to insure the drug efficacy.

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The pterocellins, bioactive alkaloids from the marine bryozoan Pterocella vesiculosa

Cited by 20 publications

References 11 publications

The Phylum Bryozoa: From Biology to Biomedical Potential

The Phylum Bryozoa: From Biology to Biomedical Potential

The Understudied Phylum Bryozoa as a Promising Source of Anticancer Drugs

Effect of bryostatin-1 as an anthelmintic drug on adult Syphacia muris infection in rats

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