The public health significance of finding autochthonous melioidosis cases in the continental United States

Torres, Alfredo G.

doi:10.1371/journal.pntd.0011550

Cited by 8 publications

(2 citation statements)

References 10 publications

(14 reference statements)

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“…However, in Limmathurotsakul et al (2016) utilized computer modeling to predict a wider distribution and suggested nearly ubiquitous endemicity throughout the tropical latitudes causing significant morbidity and mortality worldwide ( Limmathurotsakul et al, 2016 ). Consistent with that prediction, B. pseudomallei has been identified in clinical and environmental specimens in areas not previously known to be endemic, including South Asia ( Mukhopadhyay et al, 2018 ; Jayasinghearachchi et al, 2022 ), the Caribbean ( Hall et al, 2019 ; Stone et al, 2020 ), and North America ( Salam et al, 2011 ; Morosini et al, 2013 ; Torres, 2023 ).…”

Section: Introductionsupporting

confidence: 69%

Phylogenetic and phenotypic characterization of Burkholderia pseudomallei isolates from Ghana reveals a novel sequence type and common phenotypes

Schully,

Voegtly,

Rice

et al. 2024

Front. Microbiol.

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Melioidosis is a potentially severe disease caused by the gram-negative soil-dwelling bacterium called Burkholderia pseudomallei. The true breadth of the distribution of this tropical pathogen is starting to emerge with environmental and clinical isolates frequently characterized in new countries and regions. Even so, isolates, clinical cases, and genetic data from the continent of Africa remain scant. We previously confirmed the presence of B. pseudomallei in the environment of Ghana, unmasking a new area of endemicity for this pathogen. Here, we describe the genetic characteristics of isolates obtained from that environmental survey. Twenty-one isolates were subjected to whole genome sequencing and found to represent three discrete sequence types (ST), one of which was novel, and designated ST2058. Phylogenetic analysis places this novel isolate within a B. pseudomallei clade that includes genomes derived from the Americas, although it is closely related to a sub-clade that includes isolates from Africa. Importantly, phenotypic characterization demonstrates common features including API 20NE profiles and B. pseudomallei CPS to support existing diagnostics, and susceptibility to standard of care antibiotics often used in the clinical management of melioidosis. These findings add to our knowledge about the presence and distribution of B. pseudomallei in Africa and represent the first published genomes out of Ghana.

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Section: Introductionsupporting

confidence: 69%

Phylogenetic and phenotypic characterization of Burkholderia pseudomallei isolates from Ghana reveals a novel sequence type and common phenotypes

Schully,

Voegtly,

Rice

et al. 2024

Front. Microbiol.

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“…Although most commonly found in tropical and sub-tropical soil in South-East Asia and Australia, climate change is thought to have led to the recent isolation of B. pseudomallei from soil in Mississippi and Texas, and infections were linked to exposure to this soil. (19-21) B. pseudomallei also recently caused a cluster of 4 cases of melioidosis in the U.S. associated with contaminated aromatherapy spray. (22)…”

Section: Introductionmentioning

confidence: 99%

Small-molecule activators of a bacterial signaling pathway inhibit virulence

Mansour,

Qi,

Yan

et al. 2023

Preprint

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TheBurkholderiagenus encompasses multiple human pathogens, including potential bioterrorism agents, that are often extensively antibiotic resistant. The FixLJ pathway inBurkholderiais a two-component system that regulates virulence. Previous work showed thatfixLJmutations arising during chronic infection confer increased virulence while decreasing the activity of the FixLJ pathway. We hypothesized that small-molecule activators of the FixLJ pathway could serve as anti-virulence therapies. Here, we developed a high-throughput assay that screened over 28,000 compounds and identified 11 that could specifically active the FixLJ pathway. Eight of these compounds, denotedBurkholderiaFixActivator (BFA) 1-8, inhibited the intracellular survival ofBurkholderiain THP-1-dervived macrophages in afixLJ-dependent manner without significant toxicity. One of the compounds, BFA1, inhibited the intracellular survival in macrophages of multipleBurkholderiaspecies. Predictive modeling of the interaction of BFA1 withBurkholderiaFixL suggests that BFA1 binds to the putative ATP/ADP binding pocket in the kinase domain, indicating a potential mechanism for pathway activation. These results indicate that small-molecule FixLJ pathway activators are promising anti-virulence agents forBurkholderiaand define a new paradigm for antibacterial therapeutic discovery.

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Predictors of mortality in culture-proven Burkholderia pseudomallei infections in a Singapore Tertiary Hospital

Poh,

Liu,

et al. 2024

Diagnostic Microbiology and Infectious Disease

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The public health significance of finding autochthonous melioidosis cases in the continental United States

Cited by 8 publications

References 10 publications

Phylogenetic and phenotypic characterization of Burkholderia pseudomallei isolates from Ghana reveals a novel sequence type and common phenotypes

Phylogenetic and phenotypic characterization of Burkholderia pseudomallei isolates from Ghana reveals a novel sequence type and common phenotypes

Small-molecule activators of a bacterial signaling pathway inhibit virulence

Predictors of mortality in culture-proven Burkholderia pseudomallei infections in a Singapore Tertiary Hospital

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