The pulmonary biopharmaceutics and anti-inflammatory effects after intratracheal and intravenous administration of Re-Du-Ning injection

Jia-Xing, Wei; Li, Chaoyi; Chen, Weiya; Yi-Jun, Cong; Liu, Chunyu; Fei-Fei, Yang; Yong-Hong, Liao

doi:10.1016/j.biopha.2023.114335

Cited by 4 publications

(3 citation statements)

References 34 publications

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“…RDNI is used to clear heat and disperse wind and has detoxifying effects. It is widely used in the treatment of infectious emergencies, hand, foot, and mouth disease, and influenza, as well as viral infections, in disease rescue, and treatment can be effective in increasing the rate of cure and alleviating the patient's clinical symptoms (121,122). The results of this study indicated that RDNI can effectively alleviate the symptoms of pediatric AURI such as sore throat and runny nose.…”

Section: Discussion Of the Resultsmentioning

confidence: 76%

“…The results of this study indicated that RDNI can effectively alleviate the symptoms of pediatric AURI such as sore throat and runny nose. Modern pharmacology has found that Artemisia can have anti-inflammatory effects and modulate immunity, Gardenia has significant advantages in antipyretic and anti-inflammatory activity, and Honeysuckle can have antibacterial, anti-inflammatory, and antioxidant effects ( 123 ). Relevant online pharmacology and experimental validation has indicated that RDNI can downregulate the expression of inflammatory cells and proinflammatory cytokines such as human interleukin-1β, human interleukin-6, and tumor necrosis factor-α.…”

Section: Discussionmentioning

confidence: 99%

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Efficacy of five different traditional Chinese medicine injections in acute upper respiratory tract infection in children: a network meta-analysis and systematic review

Guo,

Liu,

Zhao

et al. 2024

Front. Pediatr.

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BackgroundAcute upper respiratory tract infection (AURI) includes infections caused by a variety of pathogens and is one of the most common diseases in children. Traditional Chinese medicine (TCM) injections are widely used for treating AURI in clinical practice, but their efficacy is unclear because of the lack of clear evidence. In this study, a network meta-analysis (NMA) was used to evaluate the efficacy and safety of TCM injections in the treatment of AURI and to provide a reference for clinical treatment.MethodsEight databases were searched, namely, PubMed, Embase, the Cochrane Library, Web of Science, SinoMed, China National Knowledge Infrastructure (CNKI), the Wanfang database, and the Chinese Scientific Journal database (VIP). The search time period was from 1 January 2013 to 1 November 2023. Randomized controlled trials of herbal injections for treating AURI were searched. The Cochrane Risk of Bias 2.0 tool was used to assess the quality of these studies. Review Manager 5.4 and Stata 15.0 were used for the NMA.ResultsA total of 81 papers involving 11,736 patients were included. These involved five different TCM injections, namely, Xiyanping injection (XYPI), Qingkailing injection (QKLI), Reduning injection (RDNI), Yanhuning injection (YHNI), and Tanreqing injection (TRQI). QKLI was most effective in alleviating symptoms of fever and improving overall clinical effectiveness. TRQI was most effective in relieving cough symptoms. YHNI was most effective in alleviating sore throat, runny nose, and nasal congestion. The overall incidence of adverse effects of these herbal injections in the treatment of AURI was lower, and their safety profiles were better.ConclusionsThe herbal injections combined with ribavirin improved clinical outcomes, and were superior to ribavirin injection alone in alleviating clinical symptoms such as fever, cough, sore throat, runny nose, and nasal congestion, and have favorable safety profiles.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023484099, CRD42023484099.

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Section: Discussion Of the Resultsmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Efficacy of five different traditional Chinese medicine injections in acute upper respiratory tract infection in children: a network meta-analysis and systematic review

Guo,

Liu,

Zhao

et al. 2024

Front. Pediatr.

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“… Newman and Cragg (2020) reported that from 1981 to 2019 there was 1881 new remedies, which were approved for medical application, and the 22.9% of them are of natural origin. Phytotherapy plays an important role in the treatment of cardiovascular ( Kirichenko et al, 2020 ; Archakova et al, 2022 ; Karahan et al, 2022 ), immune ( Babich et al, 2020 ; Ligacheva et al, 2022 ; Abdugafurova et al, 2024 ), cancer ( Medvedev et al, 2020 ; Kitaeva et al, 2022 ; Jia-Xing et al, 2023 ), and infectious diseases ( Gorlenko et al, 2020 ; Luzhanin et al, 2022 ; Zrig, 2022 ). According to the WHO, herbal medications are the main choice in many regions of the world ( Aware et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Insights into the stereoisomerism of dihydroquercetin: analytical and pharmacological aspects

Terekhov,

Savina,

Pankov

et al. 2024

Front. Chem.

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Dihydroquercetin (DHQ) is a representative of flavonoids that is available on the market as a food supplement and registered as an active pharmaceutical ingredient. The structure of this compound is characterized by the presence of two chiral centers in positions 2 and 3 of the pyranone ring. Current regulatory documentation on DHQ lacks quantitative analysis of the stereoisomers of this flavanonol. This poses potential risks for consumers of DHQ-based dietary supplements and developers of new drugs. This review was conducted to systematize data on the pharmacology of DHQ stereoisomers and the possible methods of controlling them in promising chiral drugs. We found that relying on literature data of polarimetry for the identification of DHQ stereoisomers is currently impossible due to these heterogeneities. NMR spectroscopy allows to distinguishing between trans- and cis-DHQ using chemical shifts values. Only HPLC is currently characterized by sufficient enantioselectivity. Regarding pharmacology, the most active stereoisomer of DHQ should be identified, if the substituents in chiral centers both take part in binding with the biological target. The significant impact of stereochemical structure on the pharmacokinetics of DHQ isomers was reported. The question about these toxicity of these compounds remains open. The results of the conducted review of scientific literature indicate the necessity of revising the pharmacology of DHQ taking into account its stereoisomerism.

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Inhalable spray-dried porous microparticles containing dehydroandrographolide succinate phospholipid complex capable of improving and prolonging pulmonary anti-inflammatory efficacy in mice

Chen,

Wei,

et al. 2024

Drug Deliv. and Transl. Res.

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The pulmonary biopharmaceutics and anti-inflammatory effects after intratracheal and intravenous administration of Re-Du-Ning injection

Cited by 4 publications

References 34 publications

Efficacy of five different traditional Chinese medicine injections in acute upper respiratory tract infection in children: a network meta-analysis and systematic review

Efficacy of five different traditional Chinese medicine injections in acute upper respiratory tract infection in children: a network meta-analysis and systematic review

Insights into the stereoisomerism of dihydroquercetin: analytical and pharmacological aspects

Inhalable spray-dried porous microparticles containing dehydroandrographolide succinate phospholipid complex capable of improving and prolonging pulmonary anti-inflammatory efficacy in mice

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