The Pulmonary Nodule After Lung Transplantation

End, Adelheid; Helbich, Thomas H.; Wisser, Wilfried; Dekan, Gerhard; Klepetko, Walter

doi:10.1378/chest.107.5.1317

Cited by 43 publications

(26 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Prior studies have reported the frequency of post-transplant bronchogenic carcinoma to range from 0% to 2.5% in SLTx recipients and to be 0% in BLTx recipients. [1][2][3][4][5] Our higher frequency of malignancy is likely explained in part by the longer-term follow-up in our study as compared with prior studies. In our cohort we included patients surviving >90 days post-transplant and who had a mean of >5 years post-transplant follow-up.…”

Section: Discussionmentioning

confidence: 49%

“…7 The mean age of our study population (55.4 years) was older than that reported in prior studies (44 to 51 years; overall mean 46.9 years); similarly, the percentage of our patients who received transplantation for COPD (75%) far exceeded the range reported in past studies (32% to 56%). [1][2][3][4][5] As our study demonstrated that increasing age and smoking history are risk factors for the development of primary post-transplant lung cancer, it is not surprising that these demographic trends would be accompanied by an increased frequency of lung cancer in this population.…”

Section: Discussionmentioning

confidence: 63%

See 1 more Smart Citation

High Frequency of Bronchogenic Carcinoma After Single-lung Transplantation

Dickson

Davis

Rea

et al. 2006

The Journal of Heart and Lung Transplantation

View full text Add to dashboard Cite

Background-Lung transplantation is a commonly employed therapy in the treatment of patients with advanced lung diseases related to tobacco use. Little is known about the long-term incidence or risk factors for primary lung cancer after lung transplantation. To determine the frequency, clinical features and risk factors for primary bronchogenic malignancy after lung transplantation, we designed a matched cohort study of single and bilateral lung transplant recipients with extended follow-up.

show abstract

Section: Discussionmentioning

confidence: 49%

Section: Discussionmentioning

confidence: 63%

High Frequency of Bronchogenic Carcinoma After Single-lung Transplantation

Dickson

Davis

Rea

et al. 2006

The Journal of Heart and Lung Transplantation

View full text Add to dashboard Cite

show abstract

“…Multiple pulmonary nodules in immunocompromised hosts are generally considered to be fungal in origin, although other infectious and non-infectious causes are seen. [3][4][5][6][7][8] Chest radiographs and computed tomography are routinely performed for the evaluation of prolonged fever in transplant recipients. 9 With the advent of high-resolution CT scanning, smaller pulmonary nodules may now be detected.…”

mentioning

confidence: 99%

Pulmonary cytolytic thrombi: a newly recognized complication of stem cell transplantation

Woodard

Gulbahce

Shreve

et al. 2000

Bone Marrow Transplant

View full text Add to dashboard Cite

Summary:Over the past 5 years we have recognized a new pulmonary complication of hematopoietic stem cell transplantation (HSCT) associated with fever and pulmonary nodules termed 'pulmonary cytolytic thrombi' (PCT). Retrospective analysis of medical and radiographic records and pathologic material from 13 HSCT recipients with PCT and a review of the Blood and Marrow Transplant Database for all patients with radiographic evidence of pulmonary nodules or who underwent openlung biopsy from 1 January 1993 to 31 December 1998 (n = 1228) were performed. The median age of patients with PCT was 11.9 years (range, 1.3-29.7 years). All patients developed fever at a median of 72 days (range, 8-343 days) post transplant, followed by pulmonary nodules on chest CT. Eleven patients were receiving therapy for active GVHD (acute, grades I-IV (n = 10); extensive chronic (n = 1) ). Biopsy of the pulmonary nodules revealed a unique pattern of necrotic, basophilic thromboemboli with amorphous material suggestive of cellular breakdown products. This was descriptively labeled 'pulmonary cytolytic thrombi'. Immunohistochemical staining revealed entrapped leukocytes and disrupted endothelium, but was negative for histiocytes. Cultures and immunohistochemical stains were negative for infectious agents. Empiric therapy included systemic corticosteroids (n = 9) and amphotericin (n = 7). Nine patients survive with resolution of PCT at a median follow-up of 1.5 years. Bone Marrow Transplantation (2000) 25, 293-300. Keywords: pulmonary nodules; stem cell transplant; pulmonary complications; cytolytic thrombi Allogeneic stem cell transplantation is used in the treatment of a variety of malignant and non-malignant conditions. The procedure and associated immunosuppression are associated with both infectious and non-infectious complications. Approximately 30-60% of allogeneic stem cell transplant recipients develop pulmonary complications.

show abstract

“…Therefore, radiologically guided FNLB might be preferred in some patients with focal pulmonary lesions after SCT. Although FNLB has been commonly used in other transplant recipients, 21,22 limited information is available on the feasibility and diagnostic yield of FNLB in the allogeneic SCT setting. In addition to the present report, we have found only one previous series of FNLB in SCT recipients.…”

Section: Discussionmentioning

confidence: 99%

Radiologically guided fine needle lung biopsies in the evaluation of focal pulmonary lesions in allogeneic stem cell transplant recipients

Jantunen

Piilonen

Volin

et al. 2002

Bone Marrow Transplant

View full text Add to dashboard Cite

Lung problems are common in allogeneic stem cell transplant (SCT) recipients. The aetiology is complex and includes infectious causes, immunological problems, pulmonary haemorrhage, adult respiratory distress syndrome (ARDS), and manifestation of malignant disease.1,2 Many pulmonary complications in allogeneic SCT recipients can now be managed effectively, although mortality is still considerable. Some potential treatments are either expensive

show abstract

The Pulmonary Nodule After Lung Transplantation

Cited by 43 publications

References 14 publications

High Frequency of Bronchogenic Carcinoma After Single-lung Transplantation

High Frequency of Bronchogenic Carcinoma After Single-lung Transplantation

Pulmonary cytolytic thrombi: a newly recognized complication of stem cell transplantation

Radiologically guided fine needle lung biopsies in the evaluation of focal pulmonary lesions in allogeneic stem cell transplant recipients

Contact Info

Product

Resources

About