The pulmonary outcome of long-term survivors after congenital diaphragmatic hernia repair

Basek, Pavel; Bajrami, Sherife; Straub, Daniel; Moeller, Alexander; Baenziger, Oskar; Wildhaber, JH; Bernet, Vera

doi:10.4414/smw.2008.11970

Cited by 4 publications

(1 citation statement)

References 21 publications

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“…We found that the association link between o/e FLV and severe acute respiratory exacerbations leading to hospitalization was not significant. Respiratory complications leading to hospitalization occur most frequently in the first 3 years of life [ 14 , 28 ]. Benoist et al [ 14 ] collected data prospectively on readmissions before 2 years of age.…”

Section: Discussionmentioning

confidence: 99%

Fetal Lung Volume Appears to Predict Respiratory Morbidity in Congenital Diaphragmatic Hernia

Cerbelle

Duc

Lejeune

et al. 2023

JCM

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Congenital diaphragmatic hernia (CDH) is associated with pulmonary hypoplasia and respiratory morbidity. To assess whether respiratory morbidity during the first 2 years of life in infants with left-sided CDH is associated with fetal lung volume (FLV) evaluated by the observed-to-expected FLV ratio (o/e FLV) on antenatal magnetic resonance imaging (MRI). In this retrospective study, o/e FLV measures were collected. Respiratory morbidity in the first 2 years of life was studied according to two endpoints: treatment with inhaled corticosteroids for >3 consecutive months and hospitalization for any acute respiratory disease. The primary outcome was a favorable progression defined by the absence of either endpoint. Forty-seven patients were included. The median o/e FLV was 39% (interquartile range, 33–49). Sixteen (34%) infants were treated with inhaled corticosteroids and 13 (28%) were hospitalized. The most efficient threshold for a favorable outcome was an o/e FLV ≥ 44% with a sensitivity of 57%, specificity of 79%, negative predictive value of 56%, and positive predictive value of 80%. An o/e FLV ≥ 44% was associated with a favorable outcome in 80% of cases. These data suggest that lung volume measurement on fetal MRI may help to identify children at lower respiratory risk and improve information during pregnancy, patient characterization, decisions about treatment strategy and research, and personalized follow-up.

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Section: Discussionmentioning

confidence: 99%