The Pulmonary Toxicity of Anticancer Agents

Yoneda, Ken Y.; Cross, Carroll E.

doi:10.1016/b978-0-08-046884-6.00924-6

Cited by 12 publications

(4 citation statements)

References 310 publications

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“…These medications are cell-cycle specific because they work at several stages of the cell cycle. The drug also has many side effects that are harmful to the human body, so it is very important to talk with a healthcare professional before taking the drugs [100]. The redox reaction of mitoxantrone is shown in figure 6.…”

Section: Mitoxantronementioning

confidence: 99%

Evaluation of the role of ionic liquid as a modifier for carbon paste electrodes in the detection of anthracyclines and purine-pyrimidine-based anticancer agents

Soni,

Kumari,

Jayaprakash

et al. 2024

Mater. Res. Express

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Ionic liquid has become a very fascinating modifier in the past few years. With the help of an ionic liquid-modified carbon paste electrode, electrochemistry has become a great way to find different drugs with a lower detection limit and high sensitivity and selectivity. The circulation of electrons of the ring in the cationic part of ionic liquid enables in lowering of the electron resistance and further enhancing the electrical conductivity. The combination of ionic liquids with various kinds of materials such as Nobel metals, metal oxides, graphene oxides, carbon nanotubes (CNT), etc. has further improved its catalytic activity as a modifier enabling faster electron transfer. Additionally, the ability of an ionic liquid to dissolve other chemicals allows for the incorporation of the electrolytes and redo-active species into the electrode, enhancing its performance. Anti-cancer drugs are life-saving but have a lot of side effects, but one of the biggest is cardiotoxicity, which is very important for saving patients' lives. So figuring out what these drugs are is a big task for scientists all over the world. Therefore, the current review enlightens the path for using ionic liquid as a modifier for the detection of anthracycline and purine-pyrimidine-based anti-cancer drugs.

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Section: Mitoxantronementioning

confidence: 99%

Evaluation of the role of ionic liquid as a modifier for carbon paste electrodes in the detection of anthracyclines and purine-pyrimidine-based anticancer agents

Soni,

Kumari,

Jayaprakash

et al. 2024

Mater. Res. Express

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“…It's a 2-phenyl amino pyrimidine derivative that has been used to treat chronic myeloid leukemia (CML), and advanced anaplastic thyroid cancer [77,78]. Imatinib acts by inhibiting Bcr-Abl, c-KIT, and platelet-derived growth factor (PDGF) tyrosine kinase activity through binding to their ATP-binding site [78][79][80]. According to the Fu et al study [81], it indicated that imatinib's most adverse events include skin color change (55.6%) and edema (38.9%).…”

Section: Imatinibmentioning

confidence: 99%

Potentials and future perspectives of multi-target drugs in cancer treatment: the next generation anti-cancer agents

Doostmohammadi,

Jooya,

Ghorbanian

et al. 2024

Cell Commun Signal

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Cancer is a major public health problem worldwide with more than an estimated 19.3 million new cases in 2020. The occurrence rises dramatically with age, and the overall risk accumulation is combined with the tendency for cellular repair mechanisms to be less effective in older individuals. Conventional cancer treatments, such as radiotherapy, surgery, and chemotherapy, have been used for decades to combat cancer. However, the emergence of novel fields of cancer research has led to the exploration of innovative treatment approaches focused on immunotherapy, epigenetic therapy, targeted therapy, multi-omics, and also multi-target therapy. The hypothesis was based on that drugs designed to act against individual targets cannot usually battle multigenic diseases like cancer. Multi-target therapies, either in combination or sequential order, have been recommended to combat acquired and intrinsic resistance to anti-cancer treatments. Several studies focused on multi-targeting treatments due to their advantages include; overcoming clonal heterogeneity, lower risk of multi-drug resistance (MDR), decreased drug toxicity, and thereby lower side effects. In this study, we'll discuss about multi-target drugs, their benefits in improving cancer treatments, and recent advances in the field of multi-targeted drugs. Also, we will study the research that performed clinical trials using multi-target therapeutic agents for cancer treatment.

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“…It is used primarily to treat several types of cancer such as leukemias, lymphomas, neuroblastoma, and sarcomas. 37,38 This alkaloid exerts cytotoxic activity by disrupting cellular microtubule formation and arrest cell growth during metaphase. This sequence induces the inhibition of cell replication, including the replication of the cancer cells.…”

Section: Antimitotic Drugsmentioning

confidence: 99%

Antimitotic Activity ofSamanea samanLeaf Extract in the In Vitro Development ofTripneustes gratillaEmbryo

Lam,

Casimpan,

Batoy

et al. 2023

Preprint

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INTRODUCTION: Commercially available anticancer drugs are expensive and may have side effects. This led the researchers to look into alternative plant sources. One of these is acacia or S. saman. OBJECTIVE: To determine whether S. saman leaf extract possesses antimitotic activity on T. gratilla embryos using vincristine sulfate as positive control. METHODOLOGY: S. saman leaves were extracted using hexane, CCl4, CHCl3, and water. T. gratilla embryos were fertilized in vitro. The fractions, vincristine sulfate, and DMSO in filtered sea water were added with the fertilized embryos in petri dishes. Samples were taken at 15 minutes after fertilization and every 30 minutes thereafter until the negative control reached a 32-cell stage. Fifty cells and their mean cell stage was evaluated per treatment. One-way ANOVA and Tukey tests were performed. RESULTS: Significant differences were seen starting at 75 minutes post fertilization up until the 165th minute using One-way ANOVA. The Tukey test showed that all aqueous and CCl4 as well as hexane (200, 400, 800 ppm) extracts had no significant difference compared to vincristine sulfate; while all CHCl3, hexane (100 ppm), and CCl4 (100 ppm) extracts showed a significant difference compared to vincristine. CONCLUSION: The aqueous, hexane, and carbon tetrachloride extracts possess potential antimitotic activity on T. gratilla embryos. Thus, it is a potential alternative to vincristine sulfate as an antimitotic agent.

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The Pulmonary Toxicity of Anticancer Agents

Cited by 12 publications

References 310 publications

Evaluation of the role of ionic liquid as a modifier for carbon paste electrodes in the detection of anthracyclines and purine-pyrimidine-based anticancer agents

Evaluation of the role of ionic liquid as a modifier for carbon paste electrodes in the detection of anthracyclines and purine-pyrimidine-based anticancer agents

Potentials and future perspectives of multi-target drugs in cancer treatment: the next generation anti-cancer agents

Antimitotic Activity ofSamanea samanLeaf Extract in the In Vitro Development ofTripneustes gratillaEmbryo

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