The Pulvinar Regulates Information Transmission Between Cortical Areas Based on Attention Demands

Saalmann, Yuri B.; Pinsk, Mark A.; Wang, Liang; Li, Xin; Kästner, Sabine

doi:10.1126/science.1223082

Cited by 907 publications

(884 citation statements)

References 57 publications

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“…A functional dysregulation of fronto-parietal networks may occur via thalamo-cortical pathways (Saalmann and Kastner, 2011;Saalmann et al, 2012;Barbas, 2006, 2007;Lakatos et al, 2008). Also, the impaired synchronization of the left dorsal fronto-parietal network may follow a dysbalance in inhibitory influences between homologous parietal regions in the two hemispheres (Battelli et al, 2009;Plow et al, 2014).…”

Section: Fronto-parietal Theta Synchronization During Visual Processingmentioning

confidence: 99%

Synchronization of fronto-parietal beta and theta networks as a signature of visual awareness in neglect

et al. 2017

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The version presented here may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the repository url above for details on accessing the published version and note that access may require a subscription. In the neglect syndrome, the perceptual deficit for contra-lesional hemi-space is increasingly viewed as a dysfunction of fronto-parietal cortical networks, the disruption of which has been described in neuroanatomical and hemodynamic studies. Here we exploit the superior temporal resolution of electroencephalography (EEG) to study dynamic transient connectivity of fronto-parietal circuits at early stages of visual perception in neglect. As reflected by interregional phase synchronization in a full-field attention task, two functionally distinct frontoparietal networks, in beta (15-25 Hz) and theta (4-8 Hz) frequency bands, were related to stimulus discrimination within the first 200 ms of visual processing. Neglect pathology was specifically associated with significant suppressions of both beta and theta networks engaging right parietal regions. These connectivity abnormalities occurred in a pattern that was distinctly different from what was observed in right-hemisphere lesion patients without neglect. Also, both beta and theta abnormalities contributed additively to visual awareness decrease, quantified in the Behavioural Inattention Test. These results provide evidence for the impairment of fast dynamic fronto-parietal interactions during early stages of visual processing in neglect pathology. Also, they reveal that different modes of fronto-parietal dysfunction contribute independently to deficits in visual awareness at the behavioural level.

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Section: Fronto-parietal Theta Synchronization During Visual Processingmentioning

confidence: 99%

Synchronization of fronto-parietal beta and theta networks as a signature of visual awareness in neglect

et al. 2017

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“…Several lines of evidence support the view that the thalamus, rather than acting primarily to integrate incoming sensory information and project it to the relevant cortical regions (Jones, 1985), has a much wider role and exerts a strong influence over cortical activity (Baxter, 2013; McAlonan, Cavanaugh, & Wurtz, 2008; O'Connor, Fukui, Pinsk, & Kastner, 2002; Purushothaman, Marion, Li, & Casagrande, 2012; Saalmann, 2014; Saalmann, Pinsk, Wang, Li, & Kastner, 2012; Theyel, Llano, & Sherman, 2010). The majority of thalamic inputs originate from the cortex, rather than sensory peripherals (Sherman & Guillery, 2013), and higher order thalamic nuclei receive dense input from cortical layers five and six, resulting in cortico‐thalamo‐cortical pathways which create indirect connections between cortical areas (Saalmann, 2014; Sherman & Guillery, 2013).…”

Section: Introductionmentioning

confidence: 99%

Thalamic functional connectivity and its association with behavioral performance in older age

et al. 2018

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IntroductionDespite the thalamus’ dense connectivity with both cortical and subcortical structures, few studies have specifically investigated how thalamic connectivity changes with age and how such changes are associated with behavior. This study investigated the effect of age on thalamo‐cortical and thalamo‐hippocampal functional connectivity (FC) and the association between thalamic FC and visual–spatial memory and reaction time (RT) performance in older adults.MethodsResting‐state functional magnetic resonance images were obtained from younger (n = 20) and older (n = 20) adults. A seed‐based approach was used to assess the FC between the thalamus and (1) sensory resting‐state networks; (2) the hippocampus. Participants also completed visual–spatial memory and RT tasks, from the Cambridge Neuropsychological Test Automated Battery (CANTAB).ResultsOlder adults exhibited a loss of specificity in the FC between sensory thalamic subregions and corresponding sensory cortex. Greater thalamo‐motor FC in older adults was associated with faster RTs. Furthermore, older adults exhibited greater thalamo‐hippocampal FC compared to younger adults, which was greatest for those with the poorest visual–spatial memory performance.ConclusionAlthough older adults exhibited poorer visual–spatial memory and slower reaction times compared to younger adults, “good” and “poorer” older performers exhibited different patterns of thalamo‐cortical and thalamo‐hippocampal FC. These results highlight the potential role of thalamic connectivity in supporting reaction times and memory in aging. Furthermore, these results highlight the importance of including the thalamus in studies of aging to fully understand how brain changes with age may be associated with behavior.

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“…1). Anterior goal networks may influence other networks by means of synchronous oscillations ; see also Engel et al 2001;Cavanagh and Frank 2014), possibly in conjunction with the thalamus (Saalmann et al 2012). "Stepwise" feedback signals in the hierarchical frontal pathways to the rostrofrontal cortex (cf.…”

Section: Maintaining and Realizing Intentionsmentioning

confidence: 99%

Working Memory: Maintenance, Updating, and the Realization of Intentions

Nyberg

Eriksson

2015

Cold Spring Harb Perspect Biol

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Correspondence: lars.nyberg@umu.se "Working memory" refers to a vast set of mnemonic processes and associated brain networks, relates to basic intellectual abilities, and underlies many real-world functions. Workingmemory maintenance involves frontoparietal regions and distributed representational areas, and can be based on persistent activity in reentrant loops, synchronous oscillations, or changes in synaptic strength. Manipulation of content of working memory depends on the dorsofrontal cortex, and updating is realized by a frontostriatal '"gating" function. Goals and intentions are represented as cognitive and motivational contexts in the rostrofrontal cortex. Different working-memory networks are linked via associative reinforcement-learning mechanisms into a self-organizing system. Normal capacity variation, as well as workingmemory deficits, can largely be accounted for by the effectiveness and integrity of the basal ganglia and dopaminergic neurotransmission.

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The Pulvinar Regulates Information Transmission Between Cortical Areas Based on Attention Demands

Cited by 907 publications

References 57 publications

Synchronization of fronto-parietal beta and theta networks as a signature of visual awareness in neglect

Synchronization of fronto-parietal beta and theta networks as a signature of visual awareness in neglect

Thalamic functional connectivity and its association with behavioral performance in older age

Working Memory: Maintenance, Updating, and the Realization of Intentions

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