The purview of doped nanoparticles: Insights into their biomedical applications

Shenoy, Raghavendra Udaya Kumar; Rama, Annamalai; Govindan, Induja; Naha, Anup

doi:10.1016/j.onano.2022.100070

Cited by 30 publications

(9 citation statements)

References 94 publications

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“…Nevertheless, the effectiveness of magnetite nanoparticles for drug delivery applications can also be improved by the intentional insertion of foreign elements within a crystal lattice to modify the properties of the starting material [ 13 , 14 , 15 , 16 , 17 ]. In this manner, the inclusion of various metal ions could further enhance the antioxidant, antimicrobial, and anticancer properties of magnetite nanoparticles [ 13 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Zinc/Cerium-Substituted Magnetite Nanoparticles for Biomedical Applications

Chircov

Mincă

Şerban

et al. 2023

IJMS

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Numerous studies have reported the possibility of enhancing the properties of materials by incorporating foreign elements within their crystal lattice. In this context, while magnetite has widely known properties that have been used for various biomedical applications, the introduction of other metals within its structure could prospectively enhance its effectiveness. Specifically, zinc and cerium have demonstrated their biomedical potential through significant antioxidant, anticancer, and antimicrobial features. Therefore, the aim of the present study was to develop a series of zinc and/or cerium-substituted magnetite nanoparticles that could further be used in the medical sector. The nanostructures were synthesized through the co-precipitation method and their morpho-structural characteristics were evaluated through X-ray diffraction (XRD), inductively coupled plasma mass spectrometry (ICP-MS), X-ray photoelectron spectroscopy (XPS), dynamic light scattering (DLS), zeta potential, scanning electron microscopy (SEM), and energy dispersive X-ray spectroscopy (EDX) analyses. Furthermore, the nanostructures were subjected to a ROS-Glo H2O2 assay for assessing their antioxidant potential, MTT assay for determining their anticancer effects, and antimicrobial testing against S. aureus, P. aeruginosa, and C. albicans strains. Results have proven promising for future biomedical applications, as the nanostructures inhibit oxidative stress in normal cells, with between two- and three-fold reduction and cell proliferation in tumor cells; a two-fold decrease in cell viability and microbial growth; an inhibition zone diameter of 4–6 mm and minimum inhibitory concentration (MIC) of 1–2 mg/mL.

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Section: Introductionmentioning

confidence: 99%

Zinc/Cerium-Substituted Magnetite Nanoparticles for Biomedical Applications

Chircov

Mincă

Şerban

et al. 2023

IJMS

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show abstract

Section: Introductionmentioning

confidence: 99%

“…45 The choice of nanoparticle used for doping can also be tailored to the target pollutant. 46 Doping ZIFs with Au nanoparticles can also improve their catalytic and adsorptive properties by increasing their surface area and enhancing their reactivity, making Au nanoparticles a promising option to enhance ZIF adsorption performance. [47][48][49] Molecular dynamics (MD), Monte Carlo (MC), and quantum mechanics (QM) are powerful molecular simulation methods that can be utilized to investigate pollutant adsorption with adsorbents.…”

Section: Introductionmentioning

confidence: 99%

pH-Sensitive adsorption of gastrointestinal drugs (famotidine and pantoprazole) as pharmaceutical pollutants by using the Au-doped@ZIF-90-glycerol adsorbent: insights from computational modeling

Montazeri,

Salahshoori,

Feyzishendi

et al. 2023

J. Mater. Chem. A

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“…Nanoparticles with both imaging and target-specific therapeutic capabilities have gained significant advantages in personalized medicine, thus allowing their application in customized targeted therapy and real-time diagnosis. 1 In this regard, specific classes of metal oxide nanomaterials such as zinc oxide nanoparticles (ZnO NPs) have gained significant attention and are promising candidates proposed for nanomedicine. However, despite their promising abilities, ZnO NPs suffer from drawbacks that could prevent their application in nanomedicine.…”

Section: Introductionmentioning

confidence: 99%

“…The use of ingenious nanomaterials in developing novel therapeutic approaches is considered a frontier in fabricating next‐generation nanosystems for biomedical applications. Nanoparticles with both imaging and target‐specific therapeutic capabilities have gained significant advantages in personalized medicine, thus allowing their application in customized targeted therapy and real‐time diagnosis 1 . In this regard, specific classes of metal oxide nanomaterials such as zinc oxide nanoparticles (ZnO NPs) have gained significant attention and are promising candidates proposed for nanomedicine.…”

Section: Introductionmentioning

confidence: 99%

Elucidating the significance of molecular interaction between sulphur doped zinc oxide nanoparticles and serum albumin using multispectroscopic approach

Mahanthappa,

Savanur,

Ramu

et al. 2023

J of Molecular Recognition

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Ingenious nanomaterials with improved biocompatibility and multifunctional properties are gaining vital significance in biomedical applications, including advanced drug delivery and nanotheranostics. In a biological system, these nanoparticles interact with serum proteins forming a dynamic corona that affects their biological or toxicological properties producing undesirable effects. Thus, the current study focuses on the synthesis of sulphur‐doped zinc oxide nanoparticles (ZnO/S NPs) and characterizing their mechanism of interaction with serum proteins using multispectroscopic approach. ZnO/S NPs were synthesized by employing a co‐precipitation approach and characterized using various analytical techniques. The results of interaction studies demonstrated that ZnO/S NPs interact with serum albumins via the static quenching process. Analysis of thermodynamic parameters (ΔG, ΔH and ΔS) revealed that the binding process is spontaneous, exothermic and van der Waals force or hydrogen bonding plays a major role. The interaction of ZnO/S NPs with tyrosine residue in bovine serum albumin was established by synchronous fluorescence spectroscopy. In addition, the results of UV–visible, circular dichroism, Fourier transform infrared, Forster's resonance energy transfer theory and dynamic light scattering spectroscopic studies revealed that the ZnO/S NPs interact with albumin by inducing the conformational changes in secondary structure and reducing the α‐helix content.

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The purview of doped nanoparticles: Insights into their biomedical applications

Cited by 30 publications

References 94 publications

Zinc/Cerium-Substituted Magnetite Nanoparticles for Biomedical Applications

Zinc/Cerium-Substituted Magnetite Nanoparticles for Biomedical Applications

pH-Sensitive adsorption of gastrointestinal drugs (famotidine and pantoprazole) as pharmaceutical pollutants by using the Au-doped@ZIF-90-glycerol adsorbent: insights from computational modeling

Elucidating the significance of molecular interaction between sulphur doped zinc oxide nanoparticles and serum albumin using multispectroscopic approach

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