The putative invertebrate adaptive immune protein Litopenaeus vannamei Dscam (LvDscam) is the first reported Dscam to lack a transmembrane domain and cytoplasmic tail

Chou, Pin Hsiang; Chang, Hao Shuo; Chen, I. Tung; Han, Lin; Chen, Yi Min; Yang, Huey Lang; Wang, Han Ching

doi:10.1016/j.dci.2009.07.006

Cited by 87 publications

(81 citation statements)

References 38 publications

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“…This challenge assay used shrimp gill tissues taken from shrimp before challenge, or from shrimps injected 60 h previously with either PBS or WSSV inoculum (prepared as described by Chou et al [15]). Samples were collected from three P. monodon individuals in each group.…”

Section: Identification Of Expressional Diversity In the Hyper-variabmentioning

confidence: 99%

“…In the shrimp Litopenaeus vannamei, a tail-less form has been reported: LvDscam lacks both a transmembrane domain (TM) and a cytoplasmic tail [14]. Chou et al (2009) suggested that LvDscam might be directly expressed as a secreted protein [14], unlike the secreted form of Drosophila Dscam which is shed from the membrane-bound form [6]. However, since Dscam has several important functions, such as its ability to bind to SH2 and SH3 proteins and trigger signal transduction, and since these pathways are evolutionarily conserved, it seems likely that shrimp must also have a membranebound form of Dscam (i.e.…”

Section: Introductionmentioning

confidence: 99%

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Penaeus monodon Dscam (PmDscam) has a highly diverse cytoplasmic tail and is the first membrane-bound shrimp Dscam to be reported

Chou

Chang

Chen

et al. 2011

Fish & Shellfish Immunology

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Section: Identification Of Expressional Diversity In the Hyper-variabmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Penaeus monodon Dscam (PmDscam) has a highly diverse cytoplasmic tail and is the first membrane-bound shrimp Dscam to be reported

Chou

Chang

Chen

et al. 2011

Fish & Shellfish Immunology

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“…All crustacean DSCAM receptors have a conserved domain structure of 10 immunoglobulin-like (Ig) domains and six fribrinogen-like (FN) domains (Fig 1) (Brites et al, 2008;Chou et al, 2009;Watthanasurorot et al, 2011). The extreme diversity of this family of receptors has been presented as a mechanism to provide a very high resolution PAMP recognition system within the invertebrates, which provides compelling support for concepts of specificity within the innate immune system of decapods.…”

Section: Diverse Families Of Pattern Recognition Proteinsmentioning

confidence: 99%

“…vannamei the receptor occurs as a soluble form (Chou et al, 2009) in the plasma whilst in the tiger shrimp P. monodon both cell surface and soluble forms of the DSCAM receptor have been reported (Chou et al, 2011). All crustacean DSCAM receptors have a conserved domain structure of 10 immunoglobulin-like (Ig) domains and six fribrinogen-like (FN) domains (Fig 1) (Brites et al, 2008;Chou et al, 2009;Watthanasurorot et al, 2011).…”

Section: Diverse Families Of Pattern Recognition Proteinsmentioning

confidence: 99%

“…Of great significance has been the identification of a family of transcriptionally variant Down Syndrome Cell Adhesion Molecule (DSCAM) receptors that were first identified in Drosophila melanogaster (Schmucker et al, 2000) and have since been characterized in the crustaceans Daphnia spp., Penaeus vannamei, P. monodon and Pacifastacus leniusculus (Brites et al, 2008;Chou et al, 2009;Chou et al, 2011;Watthanasurorot et al, 2011, respectively). Whilst initially DSCAM was reported to be involved in pathways of neuronal development during ontogeny in D.…”

Section: Diverse Families Of Pattern Recognition Proteinsmentioning

confidence: 99%

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The scope of the crustacean immune system for disease control

Hauton

2012

Journal of Invertebrate Pathology

144

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The culture or wild capture of marine and freshwater shellfish, including crustaceans, is without doubt a key source of protein for a burgeoning world population. Historically the expansion of aquaculture has, however, been accompanied by the increased incidence of economically significant diseases, most notably of viral and bacterial origin. Since the late 1970s great progress has been made in our understanding of the generalized protostome innate immune system. Distinct pathways, pathogen receptor proteins and effector molecules have since been identified that are not ancestral or homologous to those of the deuterostomes, including vertebrates. Within the past decade progress has accelerated with the rapid characterisation of new classes of recognition proteins, immune effectors and regulatory pathways. This paper provides a broad overview of our current understanding of invertebrate immunology, taking the crustacean decapod immune system as its focus. Recent developments in the field are described briefly and their implications and potential considered. These advances offer fundamental new insights in our efforts to understand disease in cultured populations and also to develop knowledge of environmental effects on host/pathogen interactions within a fishery context. Of course, challenges do remain, including the lack of an immortal cell line and the limited publically-available genomic resources. These are considered in this review as priorities for future research effort. With the continued application of more insightful technologies, coupled with associated investment, it is expected that the speed at which some of these issues are resolved will accelerate.

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Immune Response: Evolution

Baranzini

Engelmann

Grimaldi

2020

Encyclopedia of Life Sciences

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Innate immune processes arose from specific host–pathogen coevolutive interactions and the ability to recognise self and nonself structures is extremely conserved from invertebrates to vertebrates. In this context, phagocytes represent the most ancient defensive line against foreign materials, already present in earliest protostomes. Moreover, although more complex functions evolved in vertebrates, both cellular and humoral innate immune mechanisms are extremely conserved, leading to identify some forms of innate immune memory also in invertebrates. Key Concepts Phagocytosis represents the first mechanism of defence in metazoans. Immune system has evolved to discriminate self and nonself structures. Immune mechanisms present a high level of conservation throughout phyla . Vertebrate innate immune memory derives from ancient forms and mechanisms already present in invertebrates. Alternative animal models are crucial for investigating the molecular basis of the immune processes.

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The putative invertebrate adaptive immune protein Litopenaeus vannamei Dscam (LvDscam) is the first reported Dscam to lack a transmembrane domain and cytoplasmic tail

Cited by 87 publications

References 38 publications

Penaeus monodon Dscam (PmDscam) has a highly diverse cytoplasmic tail and is the first membrane-bound shrimp Dscam to be reported

Penaeus monodon Dscam (PmDscam) has a highly diverse cytoplasmic tail and is the first membrane-bound shrimp Dscam to be reported

The scope of the crustacean immune system for disease control

Immune Response: Evolution

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