The Pyroptotic and Nonpyroptotic Roles of Gasdermins in Modulating Cancer Progression and Their Perspectives on Cancer Therapeutics

Hsu, Sheng‐Kai; Chen, Y.-F.; Shu, En-De; Ko, Ching-Chung; Chang, Wei‐An; Lin, I-Hung; Li, Chia-Yang; Gallego, Rosa; Chiu, Chien‐Chih

doi:10.1007/s00005-023-00678-9

Cited by 4 publications

(2 citation statements)

References 154 publications

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“…Despite the recognized antitumor properties of pyroptosis, many questions persist, particularly regarding the functional roles of gasdermins in tumors and their impact on the tumor immune microenvironment. Addressing challenges such as minimizing collateral tissue damage from pyroptosis, such as intestinal and renal toxicity, is crucial for advancing clinical applications ( 118 ).…”

Section: Summary and Prospectmentioning

confidence: 99%

Unlocking the potential of pyroptosis in tumor immunotherapy: a new horizon in cancer treatment

Yin,

Song,

Bian

et al. 2024

Front. Immunol.

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BackgroundThe interaction between pyroptosis—a form of programmed cell death—and tumor immunity represents a burgeoning field of interest. Pyroptosis exhibits a dual role in cancer: it can both promote tumor development and counteract it by activating immune responses that inhibit tumor evasion and encourage cell death. Current tumor immunotherapy strategies, notably CAR-T cell therapy and immune checkpoint inhibitors (ICIs), alongside the potential of certain traditional Chinese medicinal compounds, highlight the intricate relationship between pyroptosis and cancer immunity. As research delves deeper into pyroptosis mechanisms within tumor therapy, its application in enhancing tumor immune responses emerges as a novel research avenue.PurposeThis review aims to elucidate the mechanisms underlying pyroptosis, its impact on tumor biology, and the advancements in tumor immunotherapy research.MethodsA comprehensive literature review was conducted across PubMed, Embase, CNKI, and Wanfang Database from the inception of the study until August 22, 2023. The search employed keywords such as “pyroptosis”, “cancer”, “tumor”, “mechanism”, “immunity”, “gasdermin”, “ICB”, “CAR-T”, “PD-1”, “PD-L1”, “herbal medicine”, “botanical medicine”, “Chinese medicine”, “traditional Chinese medicine”, “immunotherapy”, linked by AND/OR, to capture the latest findings in pyroptosis and tumor immunotherapy.ResultsPyroptosis is governed by a complex mechanism, with the Gasdermin family playing a pivotal role. While promising for tumor immunotherapy application, research into pyroptosis’s effect on tumor immunity is still evolving. Notably, certain traditional Chinese medicine ingredients have been identified as potential pyroptosis inducers, meriting further exploration.ConclusionThis review consolidates current knowledge on pyroptosis’s role in tumor immunotherapy. It reveals pyroptosis as a beneficial factor in the immunotherapeutic landscape, suggesting that leveraging pyroptosis for developing novel cancer treatment strategies, including those involving traditional Chinese medicine, represents a forward-looking approach in oncology.

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Section: Summary and Prospectmentioning

confidence: 99%

Unlocking the potential of pyroptosis in tumor immunotherapy: a new horizon in cancer treatment

Yin,

Song,

Bian

et al. 2024

Front. Immunol.

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“…Due to the heterogenicity of BC, a more precise classification of its subtypes and their corresponding individualized treatments are in urgent need [5]. Recent emerging studies have shed light on the pivotal role of programmed cell death, especially for pyroptosis, in cancer biology [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Bridging Pyroptosis and Immunity: A Comprehensive Study of the Pyroptosis-Related Long Non-Coding RNA Signature in Breast Cancer

Tian

Dong

2023

Life

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Breast cancer continuously poses serious clinical challenges to human health due to its intrinsic heterogenicity and evolving drug resistance. Recently, increasing evidence has shown that pyroptosis, known as a programmed and inflammatory form of cell death, participates in tumorigenesis, progression, and remodeling of the tumor immune microenvironment (TIME). However, a comprehensive insight into pyroptosis-related signatures for breast cancer remains elusive. The current study established a pyroptosis-related lncRNA signature using transcriptome data and corresponding clinical information from The Cancer Genome Atlas (TCGA). Pyroptosis-related gene clusters, the associated differential expression in breast cancer patients’ subtypes, and the potential mechanisms were all discussed. This integrative analysis revealed a unique signature underpinning the dichotomy of breast cancer progression and survival outcomes. Interestingly, the pyroptosis-related lncRNA signature was revealed as closely intertwined with the TIME. A correlation was established between the pyroptosis-related LncRNA signature and the TIME, underlying the mutual effect between pyroptosis and the immune responses implicated in breast cancer. The findings in this work underline the critical role exerted by pyroptosis in breast cancer, providing new insights into disease progression, prognosis, and therapeutic potential. This work has been poised to provide new avenues for personalized, immune-based cancer therapeutics by enhancing our understanding of pyroptosis in breast cancer.

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Migraine and gasdermin D: a new perspective on the inflammatory basis of migraine

Ocal,

Buldukoglu,

Hasoglan

et al. 2024

Acta Neurol Belg

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The Pyroptotic and Nonpyroptotic Roles of Gasdermins in Modulating Cancer Progression and Their Perspectives on Cancer Therapeutics

Cited by 4 publications

References 154 publications

Unlocking the potential of pyroptosis in tumor immunotherapy: a new horizon in cancer treatment

Unlocking the potential of pyroptosis in tumor immunotherapy: a new horizon in cancer treatment

Bridging Pyroptosis and Immunity: A Comprehensive Study of the Pyroptosis-Related Long Non-Coding RNA Signature in Breast Cancer

Migraine and gasdermin D: a new perspective on the inflammatory basis of migraine

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