2021
DOI: 10.1016/j.cmet.2020.12.003
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The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure

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Cited by 180 publications
(155 citation statements)
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References 126 publications
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“…Promoting the lactate transport from cytoplasm to mitochondria improved energy deficiency in heart failure (Wilson et al, 1998;McClelland and Brooks, 2002;Zhu et al, 2013). Furthermore, inhibition of MCT4 and hence lactate export in a cell model of heart failure led to further accumulation of intracellular lactate and increased lactate transport for mitochondrial oxidization (Cluntun et al, 2021).…”
Section: Heart Failurementioning
confidence: 99%
“…Promoting the lactate transport from cytoplasm to mitochondria improved energy deficiency in heart failure (Wilson et al, 1998;McClelland and Brooks, 2002;Zhu et al, 2013). Furthermore, inhibition of MCT4 and hence lactate export in a cell model of heart failure led to further accumulation of intracellular lactate and increased lactate transport for mitochondrial oxidization (Cluntun et al, 2021).…”
Section: Heart Failurementioning
confidence: 99%
“…Glycolysis-glucose oxidation mismatch is increasingly recognized as an important metabolic driver of altered ventricular remodeling. This concept has been confirmed in studies in humans (79), and in mouse models in which mitochondrial pyruvate utilization is genetically impaired (80)(81)(82)(83).…”
Section: Insulin Signaling and Pathological Hypertrophymentioning
confidence: 71%
“…Sections were post-stained with saturated uranyl acetate for 10 min followed by Reinold stain for 5 min. Sections were imaged at 120 kV with JEOL 1400 Plus 40 . Mitochondrial density and number analysis were performed using Adobe Photoshop tool using ×1500 images.…”
Section: Methodsmentioning
confidence: 99%