The Quality Evaluation of Magnesium Oxide Tablets Using Acid Neutralization Test and Dissolution Test

Inoue, Chiaki; Kogure, Toshiaki; Kamata, Aya; Ishihara, Masataka; Muraoka, Reiko; Tatsumi, Akitoshi; Tanaka, Kuniyoshi; Takeshita, Harunori; Hamaguchi, Tsuneo; Tagawa, Noriko; Kobayashi, Yoshiharu; Kadobayashi, Muneo

doi:10.1248/yakushi.127.2085

Cited by 2 publications

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References 3 publications

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“…However, continuous administration of MgO has been reported to raise the serum Mg concentration and cause hypermagnesemia, and the Ministry of Health, Labour and Welfare has recommended to refrain from its frequent administration. 6) MgO reacts with the gastric acid to neutralize and raise the pH in the stomach. 7) Therefore, MgO is used as an antacid.…”

Section: Introductionmentioning

confidence: 99%

“…6) MgO reacts with the gastric acid to neutralize and raise the pH in the stomach. 7) Therefore, MgO is used as an antacid. As antipsychotic drugs inhibit not only intestinal motility via anticholinergic action but also gastric acid secretion, it is predicted that the pH in the stomach of patients with schizophrenia may be higher than that in healthy subjects.…”

Section: Introductionmentioning

confidence: 99%

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Co-administration of Magnesium Oxide Reduces the Serum Concentration of Hydrophobic Basic Drugs in Patients Treated with Antipsychotic Drugs

Yoshida

Takahashi

Honda

et al. 2019

Biological & Pharmaceutical Bulletin

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Magnesium oxide (MgO) is a widely used laxative. Because many antipsychotic drugs are lipophilicbasic-compounds, their solubility decreases with increasing pH and changes markedly as the pH of the solution approaches their pK a. It is highly important to clarify the effect of co-administration of MgO on the serum drug concentration for effective, safe, and appropriate medication therapy. However, the relationship between MgO administration and the serum concentration of antipsychotic drugs in patients with schizophrenia has not been reported. Therefore, in the present study, we investigated the effect of MgO administration on the concentration of antipsychotic drugs in the blood of patients with schizophrenia. The serum concentrations of biperiden, zotepine, and risperidone were assayed using an LC/MS system. The correlation between the daily dose of MgO and the relative-drug-concentration (rCp) in each patient was examined. As the MgO dose was increased, the risperidone concentration decreased. The correlation coefficient decreased for risperidone, zotepine, and biperiden, in the same order. To clarify the difference in the suppression potency of MgO on the three drugs, the relationship between the physical properties and the correlation coefficients of each drug was carefully examined. A strong correlation was observed between the pK a and the correlation coefficient. Patients with schizophrenia are often prescribed antipsychotic drugs, which have anticholinergic action and tend to suppress gastric acid secretion. We concluded that basic drug absorption might be suppressed due to an increase in the stomach pH following MgO administration. Therefore, MgO co-administration is better to avoid while taking antipsychotic drugs and anticholinergic drugs.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Co-administration of Magnesium Oxide Reduces the Serum Concentration of Hydrophobic Basic Drugs in Patients Treated with Antipsychotic Drugs

Yoshida

Takahashi

Honda

et al. 2019

Biological & Pharmaceutical Bulletin

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Investigation of the Appropriate Formulation of Magnesium Oxide Powder for One-dose Package

Matsuo

Tomita

Kudo

et al. 2019

Jpn. J. Pharm. Health Care Sci.

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Magnesium oxide tablets are sometimes crushed prior to administration to patients having difficulties in swallowing tablets. However, the quality of magnesium oxide formulations may decrease when stored for a long time as a one-dose package, owing to the absorption of high amounts of moisture by magnesium oxide. Additionally, as magnesium oxide solution is alkaline, it can interact with other medicines, making it incompatible for one-dose packaging. There are three types of magnesium oxide powder formulations: crushed magnesium oxide tablets, magnesium oxide bulk powder, and magnesium oxide granules. However, the appropriate formulation of magnesium oxide for one-dose packages is unknown. The stability of powder formulations stored as one-dose packages at 75 RH for 3 months was evaluated by analyzing the change in weight change and dissolution. The dissolution of the three powder formulations did not change for 3 months. Although the weight had increased in all the formulations, the change in the weight of magnesium oxide granules was the lowest among the three formulations. Isoniazid and levodopa tablets have been reported to interact with magnesium oxide tablets. The incompatibility between the crushed powder of these medicines and magnesium oxide powder formulations was analyzed when stored as one-dose packages. Among the three formulations, incompatibility was the lowest for granule. In conclusion, preserving magnesium oxide and other formulations that causes incompatibility should basically be avoided. However, magnesium oxide granules can be used for storing with the other formulations that interact with magnesium oxide within a term to circumvent incompatibility.

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The Quality Evaluation of Magnesium Oxide Tablets Using Acid Neutralization Test and Dissolution Test

Cited by 2 publications

References 3 publications

Co-administration of Magnesium Oxide Reduces the Serum Concentration of Hydrophobic Basic Drugs in Patients Treated with Antipsychotic Drugs

Co-administration of Magnesium Oxide Reduces the Serum Concentration of Hydrophobic Basic Drugs in Patients Treated with Antipsychotic Drugs

Investigation of the Appropriate Formulation of Magnesium Oxide Powder for One-dose Package

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