Our purpose in this study was to find, report, and interpret the results of qualitative studies which investigated the experiences of older people living with cancer. We conducted systematic literature searches, identified and extracted the findings from 11 studies, and analyzed them systematically. We interpreted the findings to suggest that living with cancer in old age is to live in a perpetual state of ambiguity. The experience is characterized by a sense of disintegration, diminished identity, suffering, and social retraction. These experiences are balanced by sources of comfort and strength found within the self and among diverse relationships. The results of our study illuminate the complex, multidimensional character of living with cancer in old age. They show that older people living with cancer are resilient as well as vulnerable. We argue for changes in attitudes and behavior that will enable health care professionals to foster older peoples' resilience. In this article we report the purpose, design, conduct, and findings of a systematic search and review of qualitative research literature that investigated older peoples' experiences of living with cancer.Cancer has its highest incidence in older populations. There is extensive literature reporting the incidence and prevalence of cancers in older age groups, along with approaches to treatment and the effects and management of comorbidity (Bennahum, Forman, Vellas, & Albarede, 1997;Extermann, Overcash, Lyman, Parr, & Balducci, 1998;Satariano & Silliman, 2003). However, the subjective perceptions of older individuals undergoing the experience of cancer remain largely unknown. This review provides a basis for developing clinical health services that are based on older peoples' perceived and expressed needs.To make the most effective use of research findings, approaches to synthesizing the results of many studies on the same topic have increasingly found favor and, in quantitative research, sophisticated methods of meta-analysis have been developed which aim to produce a definitive set of findings from a wide range of work. In qualitative research, also, such an approach is deemed to be an essential part of increasing the usefulness and relevance of findings (Sandelowski, Docherty, & Emden, 1997), though the methodology is at an earlier stage of development (Dixon-Woods, Booth, & Sutton, 2007;Popay & Roën, 2003) and there has been debate about whether the approach is epistemologically appropriate (Campbell et al., 2003;McDermott, Graham, & Hamilton, 2004;Sandelowski et al., 1997). This approach is termed variously "metastudy," "metasynthesis," and "research integration." It is an approach to the literature that is more than a critical review: it is an attempt to integrate findings across studies to arrive at new understandings.Our reading of methodological literature in the field of qualitative reviewing and synthesis (Barbour, 2001;Booth, 2001;Britten et al., 2002;Campbell et al., 2003;Noblit & Hare, 1988;Paterson, Thorne, Canam, & Jillings, 2001...