The quality of placebos used in randomized, controlled trials of lumbar and pelvic joint thrust manipulation—a systematic review

Puhl, Aaron A.; Reinhart, Christine J.; Doan, Jon B.; Vernon, Howard

doi:10.1016/j.spinee.2016.11.003

Cited by 28 publications

(50 citation statements)

References 40 publications

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“…Taken in total, these data suggest that sham cold laser is an effective placebo for spinal manipulation studies and that the power of participant expectations can be quite large. These findings reinforce the conclusions from Puhl et al 26 that future trials should carefully select the control treatment, and the effectiveness of the control must be evaluated to provide confidence for assessing the effectiveness of manipulative therapy.…”

Section: Discussionsupporting

confidence: 85%

Effect of Spinal Manipulative and Mobilization Therapies in Young Adults With Mild to Moderate Chronic Low Back Pain

et al. 2020

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Section: Discussionsupporting

confidence: 85%

Effect of Spinal Manipulative and Mobilization Therapies in Young Adults With Mild to Moderate Chronic Low Back Pain

et al. 2020

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“…The search for a good placebo control in musculoskeletal pain field (e.g. physical therapy) represents an unresolved challenge [ 211 , 212 ]. Indeed, medical treatments are generally more complex than the mere administration of a drug, involving multiple treatment components that interact with each other and that are difficult to separate (e.g.…”

Section: Clinical Applications and Translational Researchmentioning

confidence: 99%

Clinical relevance of contextual factors as triggers of placebo and nocebo effects in musculoskeletal pain

Rossettini

Carlino

Testa

2018

BMC Musculoskelet Disord

205

172

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Placebo and nocebo effects are embodied psycho-neurobiological responses capable of modulating pain and producing changes at different neurobiological, body at perceptual and cognitive levels. These modifications are triggered by different contextual factors (CFs) presented in the therapeutic encounter between patient and healthcare providers, such as healing rituals and signs. The CFs directly impact on the quality of the therapeutic outcome: a positive context, that is a context characterized by the presence of positive CFs, can reduce pain by producing placebo effects, while a negative context, characterized by the presence of negative CFs, can aggravate pain by creating nocebo effects. Despite the increasing interest about this topic; the detailed study of CFs as triggers of placebo and nocebo effects is still lacked in the management of musculoskeletal pain.Increasing evidence suggest a relevant role of CFs in musculoskeletal pain management. CFs are a complex sets of internal, external or relational elements encompassing: patient’s expectation, history, baseline characteristics; clinician’s behavior, belief, verbal suggestions and therapeutic touch; positive therapeutic encounter, patient-centered approach and social learning; overt therapy, posology of intervention, modality of treatment administration; marketing features of treatment and health care setting. Different explanatory models such as classical conditioning and expectancy can explain how CFs trigger placebo and nocebo effects. CFs act through specific neural networks and neurotransmitters that were described as mediators of placebo and nocebo effects.Available findings suggest a relevant clinical role and impact of CFs. They should be integrated in the clinical reasoning to increase the number of treatment solutions, boosts their efficacy and improve the quality of the decision-making. From a clinical perspective, the mindful manipulation of CFs represents a useful opportunity to enrich a well-established therapy in therapeutic setting within the ethical border. From a translational perspective, there is a strong need of research studies on CFs close to routine and real-world clinical practice in order to underline the uncertainty of therapy action and help clinicians to implement knowledge in daily practice.

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“…However, there are no studies confirming that this is an adequate control. Future studies should success of subject blinding and ensuring inertness of their place a priori as a minimum standard for quality 62. …”

mentioning

confidence: 99%

Short-Term Changes in Algometry, Inclinometry, Stabilometry, and Urinary pH Analysis After a Thoracolumbar Junction Manipulation in Patients with Kidney Stones

Oliva-Pascual-Vaca

Punzano-Rodríguez²,

Escribá-Astaburuaga³

et al. 2017

The Journal of Alternative and Complementary Medicine

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The quality of placebos used in randomized, controlled trials of lumbar and pelvic joint thrust manipulation—a systematic review

Cited by 28 publications

References 40 publications

Effect of Spinal Manipulative and Mobilization Therapies in Young Adults With Mild to Moderate Chronic Low Back Pain

Effect of Spinal Manipulative and Mobilization Therapies in Young Adults With Mild to Moderate Chronic Low Back Pain

Clinical relevance of contextual factors as triggers of placebo and nocebo effects in musculoskeletal pain

Short-Term Changes in Algometry, Inclinometry, Stabilometry, and Urinary pH Analysis After a Thoracolumbar Junction Manipulation in Patients with Kidney Stones

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