The quantification of dipyridamole induced changes in regional deformation in normal, stunned or infarcted myocardium as measured by strain and strain rate: an experimental study

Marciniak, Maciej; Claus, Piet; Streb, Witold; Marciniak, Anna; Boettler, Petra; McLaughlin, Myles; D’hooge, Jan; Rademakers, Frank; Bijnens, Bart; Sutherland, George R.

doi:10.1007/s10554-007-9269-x

Cited by 12 publications

(9 citation statements)

References 30 publications

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“…Moreover, the prevalence of LV‐RBR and its prognostic significance are also not known in CAD. Finally, our results are in accordance with previous findings demonstrating that dipyridamole does not induce changes in regional deformation in the normal myocardium …”

Section: Discussionsupporting

confidence: 93%

Change of left ventricular “rigid body rotation” during dipyridamole‐induced vasodilation: A case from the three‐dimensional speckle tracking echocardiographic MAGYAR‐Stress Study

Nemes

Szántó

Domsik

et al. 2017

J of Clinical Ultrasound

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A patient with previous coronary stenting presented with stable angina and positive exercise treadmill test. Echocardiography with three-dimensional speckle-tracking demonstrated left ventricular rigid body rotation (near absence of left ventricular twist), whose characteristics changed dramatically during dipyridamole-induced vasodilatation. © 2017 Wiley Periodicals, Inc. J Clin Ultrasound 46:152-156, 2018.

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Section: Discussionsupporting

confidence: 93%

Change of left ventricular “rigid body rotation” during dipyridamole‐induced vasodilation: A case from the three‐dimensional speckle tracking echocardiographic MAGYAR‐Stress Study

Nemes

Szántó

Domsik

et al. 2017

J of Clinical Ultrasound

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“…Dipyridamole can also elicit the apparent improvement in myocardial thickening and contractility. The reason may be due to (1) an increase in blood flow within the LV walls that leads to myofiber stretching and an increase in contractile force due to the Gregg phenomenon, 17 (2) functional improvement of myocardium during increased coronary flow states that is related to the adenosine effect on microvasculature and improved oxygen supply consumption ratios, 18 and (3) cardioprotective effects of adenosine on glucose metabolism that tends to decrease cellular acidosis and Ca ++ overload, which may be associated with beneficial effects on mechanical function 19 …”

Section: Discussionmentioning

confidence: 99%

Assessment of Left Ventricular Wall Motion in Diabetic Rats Using Velocity Vector Imaging Combined with Stress Echocardiography

Wei

Zhang

et al. 2008

Echocardiography

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Objective: The aim of this study was to investigate whether velocity vector imaging (VVI) combined with stress echocardiography could detect potential diffused myocardial impairment of the left ventricle (LV) in diabetic rats. Methods: Thirty-five male SD rats were randomly divided into either the control group or the diabetes mellitus (DM) group (induced with STZ). VVI was performed both at rest and after dipyridamole stress in all rats 12 weeks later. Segmental peak systolic velocity (V s ), diastolic velocity (V d ), radial strain (ε r ), circumferential strain (ε c ), systolic and diastolic radial strain rate (SR r ), and circumferential strain rate (SR c ) were measured from six segments at the mid-level of the LV. Results: At rest, systolic and diastolic SR c in the DM group were significantly lower than those in the control group. After dipyridamole stress, all VVI parameters in the DM group were significantly lower than those in the control group, although all values increased significantly after dipyridamole stress compared to those at rest in both groups. Conclusions: The VVI-derived V s, V d , ε r , ε c , systolic and diastolic SR r and SR c , combined with dipyridamole stress are all effective parameters in evaluating potential myocardial impairment due to ultrastructural alterations of cardiocytes and microcirculation disturbances in DM rats. Systolic and diastolic SR c may be more sensitive indices that could be useful in detecting myocardial impairment at rest. (ECHOCARDIOGRAPHY, Volume 25, July 2008) velocity vector imaging, stress echocardiography, myocardial impairment Diabetes mellitus (DM) is one of the leading causes of death and reduction in quality of life. Many studies indicate that myocardial impairment occurs in the early stages of DM. 1-3 An easy method to evaluate the myocardial motion of the left ventricle (LV) in DM would be clinically valuable.Strain, which reflects intrinsic myocardial mechanics, is an easy, inexpensive, and rapid method to assess the myocardial motion of the LV walls. Doppler-derived strain assesses the velocity of regional myocardial motion in order to calculate strain. However, Doppler-derived strain only allows accurate measurement of the motion that parallels the ultrasound beam. 4-6

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“…Dipyridamole acts primarily by promoting coronary artery vasodilatation and seldom increases heart rate. Moreover, dipyridamole can also elicit apparent improvement in myocardial thickening and contractility . Meanwhile, this study analyzed the myocardial perfusion in the anterior walls because severe shadowing from the LV cavity affected the visibility of the posterior and lateral walls.…”

Section: Limitationmentioning

confidence: 99%

Correlation between Myocardial Dysfunction and Perfusion Impairment in Diabetic Rats with Velocity Vector Imaging and Myocardial Contrast Echocardiography

Wei

Zhang²,

et al. 2012

Echocardiography

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The purpose of this study was to investigate whether myocardial systolic dysfunction and perfusion impairment occur in diabetic rats, and to assess their relationship using velocity vector imaging (VVI) and myocardial contrast echocardiography (MCE). Forty-six rats were randomly divided into either control or the diabetes mellitus (DM) groups. DM was induced by intraperitoneal administration of streptozotocin. Twelve weeks later, 39 survival rats underwent VVI and MCE in short-axis view at the middle level of the left ventricle, both at rest and after dipyridamole stress. VVI-derived contractile parameters included peak systolic velocity (Vs ), circumferential strain (εc ), strain rate (SRc ), and their reserves. MCE-derived perfusion parameters consisted of myocardial blood flow (MBF) and myocardial flow reserve (MFR). At rest, SRc in the DM group was significantly lower than in the control group, Vs , εc , and MBF did not differ significantly between groups. After dipyridamole stress, all VVI parameters and their reserves in the DM group were significantly lower than those in the control group, MBF and MFR were substantially lower than those in the control group, too. Meanwhile, significant correlations between VVI parameter reserves and MFR were observed in the DM group. Both myocardial systolic function and perfusion were impaired in DM rats. Decreased MFR could be an important contributor to the reduction in myocardial contractile reserve.

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The quantification of dipyridamole induced changes in regional deformation in normal, stunned or infarcted myocardium as measured by strain and strain rate: an experimental study

Abstract: These results suggest that dipyridamole does not induce changes in regional deformation in normal or (partially) infarcted myocardium. Only in stunned myocardium (in the setting of single-vessel disease), dipyridamole tends to normalize deformation.

Cited by 12 publications

References 30 publications

Change of left ventricular “rigid body rotation” during dipyridamole‐induced vasodilation: A case from the three‐dimensional speckle tracking echocardiographic MAGYAR‐Stress Study

Change of left ventricular “rigid body rotation” during dipyridamole‐induced vasodilation: A case from the three‐dimensional speckle tracking echocardiographic MAGYAR‐Stress Study

Assessment of Left Ventricular Wall Motion in Diabetic Rats Using Velocity Vector Imaging Combined with Stress Echocardiography

Correlation between Myocardial Dysfunction and Perfusion Impairment in Diabetic Rats with Velocity Vector Imaging and Myocardial Contrast Echocardiography

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