The quantitative analysis of low-concentration (2%) ALA-PDT assisted with Q-switch 1064-nm Nd:YAG laser for acne vulgaris treatment

Chen, Yu-Tsung; Lin, Yun-Jhen; Chang, Chang-Cheng; Liu, Po-Heng; Huang, Yung-Hsueh; Shen, Jia-Wei; Lu, Meng-En; Chiang, Hsiu-Mei; Lin, Bor-Shyh

doi:10.1007/s10103-023-03896-x

Lasers Med Sci

2023

DOI: 10.1007/s10103-023-03896-x

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The quantitative analysis of low-concentration (2%) ALA-PDT assisted with Q-switch 1064-nm Nd:YAG laser for acne vulgaris treatment

Yu-Tsung Chen,

Yun-Jhen Lin,

Chang-Cheng Chang

et al.

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2024

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The impact of energy‐based devices on sebum in acne vulgaris: A systematic review

Jaalouk,

Pulumati,

Algarin

et al. 2024

J of Cosmetic Dermatology

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BackgroundAcne vulgaris (AV) is a widespread inflammatory skin condition associated with increased sebum production, abnormal keratinization, bacterial overgrowth, and inflammation. Overactive sebaceous glands (SGs) produce excess sebum, promote Cutibacterium acnes growth, and affect acne development. Energy‐based treatments (EBDs), including light therapy, photodynamic therapy (PDT), lasers, and radiofrequency (RF) devices, have emerged as effective treatment options. As the use of EBDs becomes more widespread, it is imperative to understand their effects on skin parameters, such as sebum, in AV.MethodsSearches were conducted in Embase, PubMed, Web of Science, and the Cochrane Library. The studies included were randomized and nonrandomized trials on facial AV that used EBDs and featured objective casual sebum level (CSL) measurements via Sebumeter. Data synthesis involved percentage reductions in CSL at follow‐ups compared to baseline.ResultsTwenty‐three studies were analyzed. PDT and RF consistently reduced CSL by 30%–40% and 30%–35%, respectively. Laser therapy showed lesser reductions, whereas light therapy varied significantly and studies had a high risk of bias. All EBD therapies were more effective than no treatment and PDT was superior to light monotherapy. Laser therapy combined with fractional microneedling radiofrequency (FMR) or as a standalone was more effective than laser alone.ConclusionNoninvasive sebum measurement provides valuable insights into AV treatment efficacy. PDT, lasers, especially the 1450‐nm diode laser, and FMR are promising for reducing sebum. Standardization of measurement techniques and further research are vital for enhancing treatment personalization, reducing side effects, and improving AV management.

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The impact of energy‐based devices on sebum in acne vulgaris: A systematic review

Jaalouk,

Pulumati,

Algarin

et al. 2024

J of Cosmetic Dermatology

View full text Add to dashboard Cite

show abstract

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The quantitative analysis of low-concentration (2%) ALA-PDT assisted with Q-switch 1064-nm Nd:YAG laser for acne vulgaris treatment

Cited by 1 publication

References 33 publications

The impact of energy‐based devices on sebum in acne vulgaris: A systematic review

The impact of energy‐based devices on sebum in acne vulgaris: A systematic review

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