The Quantitative Analysis of Zearalenone and Its Derivatives in Plasma of Patients with Breast and Cervical Cancer

Pillay, D.; Chuturgoon, Anil A.; Nevines, Elena I.; Manickum, Thavrin; Deppe, Walter; Dutton, Michael F.

doi:10.1515/cclm.2002.166

Cited by 56 publications

(43 citation statements)

References 15 publications

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“…The concentrations of zearalenone and its metabolites, α-zearalenol and β-zearalenol, present in the plasma of patients with breast (n = 28) and cervical carcinoma (n = 54) were compared with levels in patients presenting with other diagnoses (n = 26) and healthy volunteers (n = 24). There were no significant differences between the groups (Pillay et al, 2002).…”

Section: Observations In Humansmentioning

confidence: 71%

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Scientific Opinion on the risks for public health related to the presence of zearalenone in food

2011

EFSA Journal

356

142

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Zearalenone is a mycotoxin produced by several Fusarium species. It is commonly found in maize but can be found also in other crops such as wheat, barley, sorghum and rye. The European Commission asked the European Food Safety Authority to review the safety of zearalenone and the risk to consumers of a possible increase of the maximum level (ML) for zearalenone in breakfast cereals. A total of 13,075 analytical results obtained on food samples and 9,877 results on unprocessed grains sampled by 19 European countries in 2005-2010 were used in the evaluation. The highest concentrations of zearalenone were reported for wheat bran, corn and products thereof (e.g. corn flour, cornflakes). Grains and grain-based foods, in particular grains and grain milling products, bread and fine bakery wares, made the largest contribution to the estimated zearalenone exposures. Vegetable oils also made an important contribution to the zearalenone exposure. The critical effects of zearalenone result from its oestrogenic activity. Based on recent data in the most sensitive animal species, the pig, and taking into account comparisons between pigs and humans, the Panel on Contaminants in the Food Chain established a tolerable daily intake (TDI) for zearalenone of 0.25 μg/kg b.w. Estimates of chronic dietary exposure to zearalenone based on the available occurrence data are below or in the region of the TDI for all age groups and not a health concern. A potential increase in the ML for zearalenone in breakfast cereals from 50 µg/kg to 75, 100, 125 or 150 µg/kg is unlikely to result in a chronic dietary exposure exceeding the TDI. In a worst case scenario it is possible that an individual could consume the same batch of breakfast cereal containing zearalenone at the ML every day for 2 to 4 weeks, in which case exposures may exceed the TDI.

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Section: Observations In Humansmentioning

confidence: 71%

“…There were no significant differences between the groups (Pillay et al, 2002). There were no significant differences between the groups (Pillay et al, 2002).…”

Section: Observations In Humansmentioning

confidence: 73%

Scientific Opinion on the risks for public health related to the presence of zearalenone in food

2011

EFSA Journal

356

142

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“…Only few data on EDC concentrations in body fluids exist ( Table 1). The maximal concentrations of 4,4 0 -DDT, a-zearalenol, BP-3, and 4-MBC in blood are similar or higher than the respective EC 02 values (red versus gray triangles, Fig 4C) [26][27][28]. Up to 4 lM of n-NP was detected in urine, thus exceeding its EC 02 [29].…”

Section: Edcs Act At Physiologically Relevant Concentrationsmentioning

confidence: 99%

Direct action of endocrine disrupting chemicals on human sperm

et al. 2014

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Synthetic endocrine disrupting chemicals (EDCs), omnipresent in food, household, and personal care products, have been implicated in adverse trends in human reproduction, including infertility and increasing demand for assisted reproduction. Here, we study the action of 96 ubiquitous EDCs on human sperm. We show that structurally diverse EDCs activate the sperm-specific CatSper channel and, thereby, evoke an intracellular Ca 2+ increase, a motility response, and acrosomal exocytosis. Moreover, EDCs desensitize sperm for physiological CatSper ligands and cooperate in low-dose mixtures to elevate Ca 2+ levels in sperm. We conclude that EDCs interfere with various sperm functions and, thereby, might impair human fertilization.

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“…due to the regular ingestion of zearalenone (Pillay et al 2002). A major stumbling block to this conclusion is to suggest that one toxin is a cause-all agent, which is clearly a naive over simplification.…”

Section: Fb1 As a General Underlying Disease Factor In Maizementioning

confidence: 99%

The African Fusarium/maize disease

Dutton

2009

Mycotox Res

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There is a general but rather vague feeling that the use of maize (corn) as a staple foodstuff by black rural Africans is somehow a factor in, or is linked to, chronic disease found in these populations. An attempt is made in this review to consider the evidence for this connection and to identify what is actually the root of the problem. The main thrust of the argument to explain this perception is that maize is routinely contaminated with fungi and of these Fusarium verticillioides is found in maize throughout the world. Evidence is presented to this effect and, further, of the mycotoxins found in maize, the fumonisins are the most common and at the highest levels. Various animal chronic diseases arising from the consumption of contaminated maize are reviewed and possible human conditions listed, in some cases related to the known animal ones. A brief overview of the complicated cellular mechanisms of fumonisin B1 is given and it is concluded that the prime suspect in what might be called "the maize disease" can be attributed to the ingestion of this mycotoxin, sometimes in combination with other synergist mycotoxins and other disease factors, such as smoking and drinking.

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The Quantitative Analysis of Zearalenone and Its Derivatives in Plasma of Patients with Breast and Cervical Cancer

Cited by 56 publications

References 15 publications

Scientific Opinion on the risks for public health related to the presence of zearalenone in food

Scientific Opinion on the risks for public health related to the presence of zearalenone in food

Direct action of endocrine disrupting chemicals on human sperm

The African Fusarium/maize disease

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