The quantitative evaluation of contrast-enhanced ultrasound in the differentiation of small renal cell carcinoma subtypes and angiomyolipoma

Liu, Hui; Cao, Hongli; Chen, Lin; Fang, Liang; Liu, Yingchun; Zhan, Jia; Diao, Xinping; Chen, Yue

doi:10.21037/qims-21-248

Cited by 20 publications

(13 citation statements)

References 33 publications

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“…Regarding patterns of enhancement, synchronous wash‐in, iso‐enhancement at peak, and fast wash‐out were the main features of Xp11.2 tRCC in our study, and differed completely from those in ccRCC, pRCC, and chRCC. The enhancement patterns in ccRCC reported in previous studies are synchronous wash‐in, hyper‐enhancement at peak, and fast wash‐out, while those in pRCC are of slow wash‐in, hypo‐enhancement at peak, and fast wash‐out, 19,30,31 which are consistent with our findings. Previous studies have also shown that the mean microvessel density is significantly high in ccRCC, but significantly low in pRCC 26,30 .…”

Section: Discussionsupporting

confidence: 92%

“…Investigation of angiogenesis in renal lesions is still critical to understanding these differences in wash‐in enhancement patterns. Similar to that in ccRCC, pRCC, or chRCC, 21,31,32 a high percentage of heterogeneous enhancement was observed at peak enhancement in Xp11.2 tRCC lesions. Xp11.2 tRCC often presents with a low percentage of lesions with pseudocapsules, while the presence of pseudocapsules is more common in ccRCC.…”

Section: Discussionsupporting

confidence: 67%

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Contrast‐Enhanced Ultrasound Features of Adult Xp11.2 Translocation Renal Cell Carcinoma

Fan

Huang

et al. 2022

J of Ultrasound Medicine

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Objectives To investigate the sonographic features in Xp11.2 translocation renal cell carcinoma (Xp11.2 tRCC) using both conventional ultrasound (US) and contrast‐enhanced US (CEUS) and evaluate the usefulness of sonographic imaging characteristics to differentiate between Xp11.2 tRCC and the three common RCC subtypes. Methods Thirty‐four adult Xp11.2 tRCC patients who preoperatively underwent both conventional US and CEUS and had solitary renal lesions and pathological confirmation after surgery were enrolled. Control matched patients included 131 with clear cell RCC (ccRCC), 48 with papillary RCC (pRCC), and 35 with chromophobe RCC (chRCC). Conventional US and CEUS data of all patients were retrospectively analyzed and compared. Results Xp11.2 tRCC was more common in young women. The echogenicity of Xp11.2 tRCC lesions was hypo‐ and isoechoic relative to the adjacent renal cortex. A higher frequency of calcification within tumors was detected in Xp11.2 tRCC, but the presence of color flow signal (26.5%, 9/34) was much lower. Regarding CEUS features relative to the adjacent renal cortex, synchronous wash‐in (61.8%, 21/34), iso‐enhancement at peak (55.9%, 19/34), and fast wash‐out (50.0%, 17/34) were more common in Xp11.2 tRCC. Moreover, an integrated variables model based on these features could differentiate Xp11.2 tRCC from ccRCC, pRCC, and chRCC (area under the curve, sensitivity, and specificity: 0.934, 92.0%, and 86.0%; 0.907, 88.0%, and 87.0%; and 0.808, 65.0%, and 99.0%, respectively). Conclusions Combining conventional US and CEUS lesion features with clinical information may provide a feasible and effective method to differentiate Xp11.2 tRCC from ccRCC, pRCC, and chRCC.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 67%

Contrast‐Enhanced Ultrasound Features of Adult Xp11.2 Translocation Renal Cell Carcinoma

Fan

Huang

et al. 2022

J of Ultrasound Medicine

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“…In consequence, CEUS may represent a reliable tool to detect potentially malignant SRMs. This result is mainly imputable to the study from Liu et al, which relied on an adequate sample size ( n = 97) and reported a sensitivity of 1.00 (95% CI: 0.96–1.00) [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Performance of Contrast-Enhanced Ultrasound in the Evaluation of Small Renal Masses: A Systematic Review and Meta-Analysis

et al. 2022

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Ultrasound (US) is a highly sensitive imaging tool in the detection of renal masses. However, the detection rate of small renal masses (SRMs) (<4 cm) is still limited. In this scenario, contrast-enhanced ultrasound (CEUS) is a relatively novel, but increasingly utilized, diagnostic modality which aims to increase the overall diagnostic ability in the identification of SRMs. In consequence, we performed a systematic review (SR) and pooled meta-analysis to investigate the diagnostic performance of CEUS in the evaluation of SRMs confirmed by pathology. A SR up to April 2022 was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The diagnostic performance of CEUS was evaluated basing on malignant vs. benign SMRs. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) from eligible studies were pooled, and summary receiver operating characteristic (SROC) curves were constructed for each endpoint. Overall, five qualified studies were deemed suitable for this meta-analysis. Finally, diagnostic performance of CEUS showed an accuracy of 0.93 in detecting malignant masses (sensitivity of 0.94, PPV of 0.95, specificity of 0.78, and NPV of 0.73). Taken together, CEUS may represent a promising minimally invasive diagnostic tool for characterization of SMRs, since it allows clinicians to identify malignant lesions.

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“…Contrast-enhanced ultrasound (CEUS) is a widely-used, safe, and effective imaging technique that visualizes microvascularization using specific contrast agents (1)(2)(3). The contrast agents are lipid-encapsulated microbubbles with a diameter of about 1-10 μm.…”

Section: Introductionmentioning

confidence: 99%

Prolonged heterogeneous liver enhancement accompanied by abdominal symptoms after sonographic contrast agent injection: a cross-sectional study

Tang¹,

Xi²,

Wang³

et al. 2023

Quant Imaging Med Surg

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Background: To report the occurrence of abdominal symptoms in patients who presented with prolonged heterogeneous liver enhancement (PHLE) after injecting contrast agent SonoVue ® .Methods: A total of 105 patients who indicated to have contrast-enhanced ultrasound (CEUS) examinations were consecutively observed. The liver scanning under ultrasound was performed before and after the contrast agent injection. Patients' basic information, clinical manifestations, and ultrasound images under B-mode and CEUS mode were respectively recorded. For patients exhibiting abdominal symptoms, the occurrence and last time of symptoms were recorded in detail. We subsequently compared the difference in clinical characteristics between patients with and without the PHLE phenomenon. Results:In 20 patients with the PHLE phenomenon, 13 showed abdominal symptoms. Eight patients (61.5%) appeared to have mild defecation sensation, and five (38.5%) showed apparent abdominal pain.The PHLE phenomenon began to appear within 15 minutes to 1.5 hours after the intravenous injection of SonoVue ® . This phenomenon lasted for 30 minutes to 5 hours in ultrasound. Patients with severe abdominal symptoms showed large-area and diffuse PHLE patterns. Only sparse hyperechoic spots in the liver were detected in patients with mild discomfort. Abdominal discomfort resolved spontaneously in all patients.Meanwhile, the PHLE gradually disappeared without any medical treatment. In the PHLE-positive group, the proportion of patients with a history of gastrointestinal disease was significantly higher (P=0.02).Conclusions: Patients with the PHLE phenomenon can exhibit abdominal symptoms. We suggest gastrointestinal disorders may contribute to PHLE, which can be considered a harmless phenomenon that does not affect the safety profile of SonoVue ® .

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The quantitative evaluation of contrast-enhanced ultrasound in the differentiation of small renal cell carcinoma subtypes and angiomyolipoma

Cited by 20 publications

References 33 publications

Contrast‐Enhanced Ultrasound Features of Adult Xp11.2 Translocation Renal Cell Carcinoma

Contrast‐Enhanced Ultrasound Features of Adult Xp11.2 Translocation Renal Cell Carcinoma

Diagnostic Performance of Contrast-Enhanced Ultrasound in the Evaluation of Small Renal Masses: A Systematic Review and Meta-Analysis

Prolonged heterogeneous liver enhancement accompanied by abdominal symptoms after sonographic contrast agent injection: a cross-sectional study

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