The Quantitative Measurements of Vascular Density and Flow Areas of Macula Using Optical Coherence Tomography Angiography in Normal Volunteers

Ghassemi, Fariba; Fadakar, Kaveh; Bazvand, Fatemeh; Mirshahi, Reza; Mohebbi, Masoumeh; Sabour, Siamak

doi:10.3928/23258160-20170601-06

Cited by 29 publications

(42 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Shahlaee et al observed similar VDs to ours for the parafoveal region in the SCP and DCP (46% ± 2.2% and 52% ± 2.4%, respectively) and again values were significantly higher in the DCP (P < .001). 24 In the latter study, higher values in both retinal plexus could be due to the different layering of the superficial and deep capillary networks. 5 These authors reported mean VDs of 52.6% ± 3.2% and 57.9% ± 2.8% for the SCP and DCP, respectively, and values were always significantly higher for the DCP in all parafoveal subfields.…”

Section: Discussionmentioning

confidence: 68%

“…5,6,[20][21][22][23][24] In this study, a commercial SS-OCTA device equipped with new software was used to quantify VD in the macula. Such reference data can then be compared with measurements made in a variety of retinal diseases to detect different anomalies ideally in early disease stages.…”

Section: Discussionmentioning

confidence: 99%

“…5,6,[20][21][22][23][24] In this study, a commercial SS-OCTA device equipped with new software was used to quantify VD in the macula. 24 Probably the lower VD values detected in the present study are attributable to the spectral-domain OCTA device employed, which uses a different algorithm. 27 Other authors have also reported good reproducibility for the use of different OCTA devices (RTVue Avanti, Fremont, California; ICC ≥ .873) 6 or the Plex Elite (Carl Zeiss Meditec, Jena, Germany; ICC ≥ .70).…”

Section: Discussionmentioning

confidence: 99%

“…18 Moreover, the number of capillaries seen in the capillary-free zone along retinal arteries seems to be much greater on histology than OCTA, and this could be a limitation of current OCTA techniques. 5,6,[20][21][22][23][24] Before OCTA technology can be routinely used in clinical practice and clinical trials, normative data such as macular VD is needed. 5,6,[20][21][22][23][24] Before OCTA technology can be routinely used in clinical practice and clinical trials, normative data such as macular VD is needed.…”

Section: Introductionmentioning

confidence: 99%

“…19 As this technology is relatively new, there are still scarce normative OCTA data and little is also known about the influence of or correlation between different ocular or general parameters and VD. 5,6,[20][21][22][23][24] Before OCTA technology can be routinely used in clinical practice and clinical trials, normative data such as macular VD is needed. As stated by Wang et al, it is mandatory to know the normal variation of a parameter and its associations when it is to be used to diagnose diseases.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Normative database and determinants of macular vessel density measured by optical coherence tomography angiography

Fernández‐Vigo

Kudsieh²,

Shi

et al. 2019

Clinical Exper Ophthalmology

View full text Add to dashboard Cite

Importance To provide a normative vessel density (VD) database for the macula through swept‐source optical coherence tomography angiography (OCTA) and to assess the main determinants of this measurement. Background In contrast with dye angiography, the recently introduced OCTA technique allows for the non‐invasive measurement of retinal and choroidal VD metrics. Design Cross‐sectional study. Participants The right eyes of 346 healthy subjects were studied. In 105 subjects both eyes were imaged. Methods Foveal and parafoveal macular VD measurements were obtained in the retinal superficial capillary plexus (SCP), deep capillary plexus (DCP), and in the choriocapillaris (CC) layer. Also recorded were age, sex, axial length (AL), foveal and choroidal thickness (CT). Main Outcome Measures Normative database and determinants of macular VD measured by OCTA. Results Mean participant age was 38.3 ± 20.1 years (mean ± SD) (range 5‐83). Foveal VDs in the different plexuses were: SCP 22.1% ± 5.0% (7.3‐35.1), DCP 19.9% ± 6.3% (6.9‐51.2) and CC: 52.8% ± 4.3% (40.2‐62.1). Parafoveal VDs ranged from 45.4% ± 3.7% to 51.8% ± 4.6%. Positive correlation was observed between foveal VD and foveal thickness (R = .327), as well as between parafoveal DCP VD and CT (R = .250;P ≤ .006), while correlation with age was negative in the SCP and CC (R = −.283;P < .001). No associations were detected between macular VD and sex or AL (P ≥ .05). Conclusion and Relevance Macular VD showed wide individual variation, was positively correlated with foveal thickness and with CT, negatively correlated with age, and showed no correlation with AL or sex.

show abstract

Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Normative database and determinants of macular vessel density measured by optical coherence tomography angiography

Fernández‐Vigo

Kudsieh²,

Shi

et al. 2019

Clinical Exper Ophthalmology

View full text Add to dashboard Cite

show abstract

Multimodal Retinal Imaging in Incontinentia Pigmenti Including Optical Coherence Tomography Angiography

et al. 2018

View full text Add to dashboard Cite

IMPORTANCE Incontinentia pigmenti (IP) is a rare, X-linked dominant disease with potentially severe ocular complications that predominantly affect the peripheral retina. However, little is known about its effects on the macula. OBJECTIVE To describe the structural and vascular abnormalities observed in the maculas of patients with IP and to correlate these findings with peripheral pathologies. DESIGN, SETTING, AND PARTICIPANTS Prospective, cross-sectional study at Wilmer Eye Institute, Johns Hopkins University. Five participants with a clinical diagnosis of IP were included and underwent multimodal imaging with ultra-wide-field fluorescein angiography (FA), spectral-domain optical coherence tomography (OCT), and OCT angiography. MAIN OUTCOMES AND MEASURES The structural and vascular abnormalities observed on spectral-domain OCT and OCT angiography and their correlation with peripheral pathologies seen on ultra-wide-field FA. RESULTS A total of 9 eyes from 5 patients (median age, 20.5 years; range, 8.4-54.2 years) were included. Median Snellen visual acuity was 20/32 (range, 20/16 to 20/63). ultra-wide-field FA-identified retinal vascular abnormalities in all 7 eyes in which FA was obtained. These abnormalities included microaneurysms, areas of nonperfusion, and vascular anastomoses, most of which were peripheral to the standard view of 30°FA with peripheral sweeps. Structural abnormalities were observed in 6 eyes on spectral-domain OCT, including inner retinal thinning and irregularities in the outer plexiform layer. Optical coherence tomography angiography abnormalities were noted in all 9 eyes, including decreased vascular density, abnormal vascular loops, and flow loss in the superficial and deep plexuses, which corresponded to areas of retinal thinning on spectral-domain OCT. CONCLUSIONS AND RELEVANCE Although our study is limited by the small sample size, the findings suggest that multimodal imaging is useful for detecting structural and vascular abnormalities that may not be apparent on ophthalmoscopy in patients with IP. Macular pathologies, especially a decrease in vascular density on OCT angiography, are common. Further studies are needed to characterize further the association between macular and peripheral abnormalities in patients with IP.

show abstract

Association of Optical Coherence Tomography and Optical Coherence Tomography Angiography Retinal Features With Visual Function in Older Adults

et al. 2022

View full text Add to dashboard Cite

IMPORTANCEAlthough there is abundant evidence relating neuronal and vascular optical coherence tomography (OCT) and OCT angiography (OCTA) measures to retinal disease, data on the normative distribution of retinal features and their associations with visual function in a healthy, older, community-based population are sparse.OBJECTIVES To characterize the normative OCT and OCTA measures in older adults and describe their associations with visual function. DESIGN, SETTING, AND PARTICIPANTSThis was a cross-sectional, observational study conducted from May 17, 2017, to May 31, 2019. The study included a community-based sample. Participants in the Atherosclerosis Risk in Communities study from Jackson, Mississippi (all self-reported Black participants), and Washington County, Maryland (all self-reported White participants), were recruited in the Eye Determinants of Cognition study (EyeDOC). Data analyses were conducted from June 14, 2020, to May 31, 2021. MAIN OUTCOMES AND MEASURES Retinal measurements, including retinal nerve fiber layer (RNFL) thickness, macular ganglion cell complex (GCC) thickness, macular vessel density (VD) in the superficial capillary plexus (SCP) and deep capillary plexus (DCP), and foveal avascular zone (FAZ) area, were captured with spectral-domain OCT and OCTA. Visual function, including presenting distance vision, corrected distance vision, near visual acuity (VA), and contrast sensitivity (CS), was assessed. RESULTS A total of 759 participants (mean [SD] age, 80 [4.2] years; 480 female participants [63%]; 352 Black participants [46%]) were included in the study. Mean (SD) GCC thickness (89.2 [9.3] μm vs 92.3 [8.5] μm) and mean (SD) FAZ (0.36 [0.16] mm 2 vs 0.26 [0.12] mm 2 ) differed between Jackson and Washington County participants, respectively. Mean (SD) RNFL thickness and mean (SD) VD in SCP and DCP were greater for participants 80 years or younger than for participants older than 80 years (RNFL: Յ80 years, 93.2 [10.5] μm; >80 years, 91.1 [11.6] μm; VD SCP, Յ80 years, 44.3% [3.5%]; >80 years, 43.5% [3.8%]; VD DCP, Յ80 years, 44.7% [4.9%]; >80 years, 43.7% [4.8%]). Linear regression showed each 10-μm increment in RNFL thickness and GCC thickness was positively associated with 0.016 higher logCS among all participants (RNFL: 95% CI, 0.005-0.027; P = .004; GCC: 95% CI, 0.003-0.029; P = .02), with stronger associations among Jackson participants. The associations of VA and structural measures were found only in Jackson participants, with coefficients per 10-μm increment of 0.012 logMAR VA (RNFL: 95% CI, 0.000-0.023; P = .049) and 0.020 logMAR VA (GCC: 95% CI, 0.004-0.034; P = .04). CONCLUSIONS AND RELEVANCEIn this cross-sectional study, better CS was associated with greater RNFL thickness and GCC thickness, but no visual measures were associated with angiographic features overall. These findings suggest that clinical application of normative references for OCT-and OCTA-based measures should consider demographic and community features.

show abstract

The Quantitative Measurements of Vascular Density and Flow Areas of Macula Using Optical Coherence Tomography Angiography in Normal Volunteers

Cited by 29 publications

References 32 publications

Normative database and determinants of macular vessel density measured by optical coherence tomography angiography

Normative database and determinants of macular vessel density measured by optical coherence tomography angiography

Multimodal Retinal Imaging in Incontinentia Pigmenti Including Optical Coherence Tomography Angiography

Association of Optical Coherence Tomography and Optical Coherence Tomography Angiography Retinal Features With Visual Function in Older Adults

Contact Info

Product

Resources

About