Mineralogically distinct leucogranite bodies in the Topsham-Brunswick area of coastal southwestern Maine have principally Permian crystallization ages, and similar initial Nd (ε Nd [278 Ma] = -5.2 to -3.7) and Pb isotope compositions ( 206 Pb/ 204 Pb = 18.40-18.46; 207 Pb/ 204 Pb = 15.61-15.66; 208 Pb/ 204 Pb = 38.19-38.41), indicating their derivation from similar source materials. However, the major and trace element contrast between these rocks does not favor their relation through simple fractionation processes. The sources of the leucogranites are distinct from the sources of fine-grained biotite granites farther east in Phippsburg (ε Nd [278 Ma] = -2.4 to -1.6) and from country-rock migmatites (-2.9 to +0.8). The leucogranites have initial Pb isotopic compositions that overlap those of abundant evolved granitic pegmatites in Topsham.The biotite granite in Phippsburg may be derived completely from material with relatively juvenile Nd isotope signatures, comparable to Avalon-like basement or to the Topsham-Brunswick area migmatites. The Topsham-Brunswick leucogranite Nd isotope data require input from more evolved sources than the rocks they intrude. A Central Maine belt source component is not favored, due to regional tectonic relations. The leucogranite isotope data are best explained through derivation from non-North American sources. These sources display a degree of Nd isotope distinction from typical Avalonian basement. Juxtaposition across the Norumbega fault zone of granites derived from isotopically distinct basement sources may indicate that this structure is at some crustal level a fundamental division between different exotic basement terranes.