2024
DOI: 10.20517/2347-9264.2024.11
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The radiated breast and autologous reconstruction: benefits and alternatives

Jane N. Ewing,
Zachary Gala,
Mehdi S. Lemdani
et al.

Abstract: Despite advancements in research and technology, breast cancer remains the second leading cause of cancer-related mortality affecting women worldwide. Radiation therapy is a widely recommended adjunct to surgery due to its significant role in reducing loco-regional recurrence. Its use, however, is not without consequences. Radiation triggers a series of pathophysiologic events leading to tissue injury; reactive oxygen species incites (1) vascular damage and chronic hypoxia; (2) an inflammatory response; and (… Show more

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