The radiation-induced degradation of hyaluronic acid

Deeble, David J.; Phillips, Glyn O.; Bothe, Eberhard; Schuchmann, Heinz‐Peter; Sonntag, Clemens von

doi:10.1016/1359-0197(91)90208-j

Cited by 11 publications

(7 citation statements)

References 8 publications

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“…UV irradiation reduces the viscosity of HA solutions. , The intervention of reactive oxygen radicals and singlet oxygen in connection with UV irradiation, led to destruction of the interglycosidic bonds in addition to decarboxylation. UV irradiation-mediated degradation of HA has been confirmed. ,, …”

Section: 3 Degradation By Free Radicalsmentioning

confidence: 77%

Hyaluronan: Preparation, Structure, Properties, and Applications

Lapčík

Smedt²,

Demeester³

et al. 1998

Chem. Rev.

671

313

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under Prof. S. Claesson. Holding 24 industrial patents and author of more than 120 publications, he has lectured at several European universities. His current interest is in the photochemistry and physical chemistry of polymers. He is a member of the Czech Chemical Society. Stefaan De Smedt was born in Geraardsbergen, Belgium, in 1967. He studied pharmacy at the University of Ghent, Belgium, and received his M.S. degree in pharmaceutical sciences in 1990. As a scholar of the Belgian Institute for the Encouragement of Scientific Research in Industry and Agriculture, he enrolled in a Ph.D. program at the University of Ghent, under the direction of Prof. J. Demeester. He studied rheology at the Catholic University of Leuven. He received the Scott Blair Biorheology Award in 1993−1995 for his work on the structural characterization of hyaluronan solutions. To study diffusion phenomena in polymer solutions, he collaborated with Prof. Y. Engelborghs at the Laboratory of Biomolecular Dynamics of the Catholic University of Leuven. In 1995, he joined the pharmaceutical development group of Janssen Research Foundation. Since 1997 he has been a postdoctoral fellow of F.W.O.-Vlaanderen at the Laboratory of General Biochemistry and Physical Pharmacy of the University of Ghent. He is a member of the Controlled Release Society, the European Federation for Pharmaceutical Sciences, the Belgian Society for Pharmaceutical Sciences, the European Society of Rheology, the Belgian Biophysical Society, and the Polymer Networks Group. He is a consultant to the Journal of Controlled Release and to Pharmaceutical Research. His current research interests include the mobility and interactions of macromolecular drugs in pharmaceutical polymer matrixes and biological polymer systems.

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Section: 3 Degradation By Free Radicalsmentioning

confidence: 77%

Hyaluronan: Preparation, Structure, Properties, and Applications

Lapčík

Smedt²,

Demeester³

et al. 1998

Chem. Rev.

671

313

View full text Add to dashboard Cite

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“…Hydroxyl radicals react with low-molecular-weight carbohydrates by abstraction of carbon-bound hydrogens with a rate constant k > 1 × 10 9 dm 3 mol Ϫ1 s Ϫ1 , while the reactivity of H atoms is more than an order of magnitude lower. 36, 38 Due to a different reaction geometry, the rate constants of the reactions of OH radicals with polymers, when expressed in dm 3 (mol of repeating unit) Ϫ1 s Ϫ1 , are lower than for the lowmolecular-weight analogues. They depend on the molecular weight and conformation of the macromolecules and, to a certain extent, also on their concentration.…”

Section: Reaction Of Oh Radicals With Chitosanmentioning

confidence: 99%

OH-Radical-induced chain scission of chitosan in the absence and presence of dioxygen

Ulański

Sonntag

2000

J. Chem. Soc., Perkin Trans. 2

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“…If we consider our results, the estimated values are relatively high in comparison with those of other polysaccharides. The hydroxyl radical reacts with low‐molecular‐weight carbohydrates, that is, glucose, fructose, and so forth, by an abstraction of carbon‐bound hydrogen atoms, with the rate constant greatly exceeding 10 9 dm 3 mol −1 s −1 13, 25. However, its reactivity toward polysaccharides is usually much lower, about 10 7 –10 8 dm 3 mol −1 s −1 .…”

Section: Resultsmentioning

confidence: 99%

Laser flash photolysis of carboxymethylcellulose in an aqueous solution

Wach

Kudoh

Zhai

et al. 2004

J. Polym. Sci. A Polym. Chem.

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Laser flash photolysis with excitation at 248 nm was used to study photochemically derived changes of carboxymethylcellulose (CMC) in aqueous solutions. Transient absorption spectra of solutions after photolysis revealed a broad band with a maximum of approximately 720 nm, which could be ascribed to the signal of the hydrated electron. The interaction of the hydrated electron with CMC was slow (Ͻ10 7 dm 3 mol Ϫ1 s Ϫ1 ), but the OH radical, formed by the decomposition of H 2 O 2 , reacted with CMC at a high rate constant (9.5-11.0 ϫ 10 8 dm 3 mol Ϫ1 s Ϫ1 ). The rate constant of the reactions of CMC with hydroxyl radicals depended on the conformation of the macromolecules, which was determined by the pH of the solution. Transient absorption was recorded at a wavelength shorter than 370 nm for CMC solutions photolyzed in the presence of H 2 O 2 . As a result of OH attack, long-lived radicals were formed on CMC. The recombination of macroradicals led to the formation of crosslinking bonds between side-chain groups, and as a result of it an insoluble gel arose in low-pH solutions.

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The radiation-induced degradation of hyaluronic acid

Cited by 11 publications

References 8 publications

Hyaluronan: Preparation, Structure, Properties, and Applications

Hyaluronan: Preparation, Structure, Properties, and Applications

OH-Radical-induced chain scission of chitosan in the absence and presence of dioxygen

Laser flash photolysis of carboxymethylcellulose in an aqueous solution

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