The Radiologic Spectrum of Cardiopulmonary Amyloidosis

Himmelfarb, Elliot; Wells, Stanley; Rabinowitz, Jack G.

doi:10.1378/chest.72.3.327

Cited by 56 publications

(28 citation statements)

References 15 publications

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“…Interstitial amyloidosis occasionally occurs as a consequence of lung infiltration of B-cell malignancies [39,45,59] producing an amyloidogenic monoclonal protein, as well as in rare cases of lung metastases of medullary carcinoma of the thyroid [58][59][60]. In these cases, amyloid deposition is responsible for most of the infiltrative pattern on chest radiographs.…”

Section: Diffuse Alveolar-septal Amyloidosismentioning

confidence: 99%

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The lung in amyloidosis

et al. 2017

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Amyloidosis is a disorder caused by misfolding of autologous protein and its extracellular deposition as fibrils, resulting in vital organ dysfunction and eventually death. Pulmonary amyloidosis may be localised or part of systemic amyloidosis.Pulmonary interstitial amyloidosis is symptomatic only if the amyloid deposits severely affect gas exchange alveolar structure, thus resulting in serious respiratory impairment. Localised parenchymal involvement may be present as nodular amyloidosis or as amyloid deposits associated with localised lymphomas. Finally, tracheobronchial amyloidosis, which is usually not associated with evident clonal proliferation, may result in airway stenosis.Because the treatment options for amyloidosis are dependent on the fibril protein type, the workup of all new cases should include accurate determination of the amyloid protein. Most cases are asymptomatic and need only a careful follow-up. Diffuse alveolar-septal amyloidosis is treated according to the underlying systemic amyloidosis. Nodular pulmonary amyloidosis is usually localised, conservative excision is usually curative and the long-term prognosis is excellent. Tracheobronchial amyloidosis is usually treated with bronchoscopic interventions or external beam radiation therapy.

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Section: Diffuse Alveolar-septal Amyloidosismentioning

confidence: 99%

“…Tracheobronchial amyloidosis, most often presenting as multifocal submucosal plaques, is an organ-limited type of amyloidosis, which is usually not associated with detectable systemic lymphoplasmacytic clonal proliferation [28,29,44,47,59,[68][69][70][71][72]. The association with multiple myeloma is extremely rare [73].…”

Section: Tracheobronchial Amyloidosismentioning

confidence: 99%

The lung in amyloidosis

et al. 2017

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“…Amyloid nodules are commonly peripheral and subpleural in location, usually affect the lower lobes, may be bilateral, and may reach a diameter of 15 cm. The prognosis of nodular amyloidosis is usually excellent (57,58). …”

Section: Pulmonary Amyloidosismentioning

confidence: 99%

Pulmonary Manifestations of Sjögren’s Syndrome

Stojan

Baer

Danoff

2013

Curr Allergy Asthma Rep

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“…A further complication is the fact that many subgroups of respiratory amyloid exist and there are important differences in presenting symptoms, signs, prognosis, and management. Prowse,5 Weiss,6 Spencer,7 Wilson et al, 8 Himmelfarb et al,9 and Rubinow et al'0 have all extensively reviewed localised respiratory amyloid and have proposed their own classifications. These, however, are conflicting and in some instances confusing.…”

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confidence: 99%